Probing gorge dimensions of cholinesterases by freeze-frame click chemistry

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 161-165

  Radić, Zoran ^a   Manetsch, Roman ^b   Fournier, Didier ^c   Sharpless, K Barry ^d   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acetylcholinesterase; Active center gorge; Click chemistry; Drosophila acetylcholinesterase; Femtomolar inhibitors; Species specific inhibitors

Indexed keywords

ACETYLENE; AZIDE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; PROPIDIUM IODIDE; TACRINE; TRIAZOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; FISH; LIGAND BINDING; MACROMOLECULE; MAMMAL; MOLECULAR MODEL; NONHUMAN; PROTEIN FAMILY;

ACETYLCHOLINESTERASE; ANIMALS; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA;

EID: 50649094935     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.04.048     Document Type: Article

References (10)

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