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Volumn 58, Issue 1, 2008, Pages 58-64

Treatment with pharmacological peroxisome proliferator-activated receptor α agonist clofibrate increases intestinal carnitine absorption in rats

Author keywords

Clofibrate; Intestinal carnitine absorption; OCTN2; PPAR activation; Rat; Small intestine

Indexed keywords

ACYL COENZYME A OXIDASE; AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER ATB0+; CARNITINE; CLOFIBRATE; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; UNCLASSIFIED DRUG;

EID: 50649085921     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2008.06.006     Document Type: Article
Times cited : (27)

References (42)
  • 1
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry J.D., and Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 244 (1997) 1-14
    • (1997) Eur J Biochem , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 2
    • 4444315751 scopus 로고    scopus 로고
    • Carnitine: a nutritional, biosynthetic, and functional perspective
    • Steiber A., Kerner J., and Hoppel C.L. Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med 25 (2004) 455-473
    • (2004) Mol Aspects Med , vol.25 , pp. 455-473
    • Steiber, A.1    Kerner, J.2    Hoppel, C.L.3
  • 3
    • 0031816464 scopus 로고    scopus 로고
    • Carnitine metabolism and its regulation in microorganisms and mammals
    • Rebouche C.J., and Seim H. Carnitine metabolism and its regulation in microorganisms and mammals. Annu Rev Nutr 18 (1998) 39-61
    • (1998) Annu Rev Nutr , vol.18 , pp. 39-61
    • Rebouche, C.J.1    Seim, H.2
  • 4
    • 23244446985 scopus 로고    scopus 로고
    • l-Carnitine: new aspects of a known compound-a brief survey
    • 10.1007/s00706-005-0339-2
    • Lohninger A., Pittner G., and Pittner F. l-Carnitine: new aspects of a known compound-a brief survey. Chem Monthly 136 (2005) 1255-1268 10.1007/s00706-005-0339-2
    • (2005) Chem Monthly , vol.136 , pp. 1255-1268
    • Lohninger, A.1    Pittner, G.2    Pittner, F.3
  • 5
    • 0036471216 scopus 로고    scopus 로고
    • Carnitine biosynthesis in mammals
    • Vaz F.M., and Wanders R.J. Carnitine biosynthesis in mammals. Biochem J 361 (2002) 417-429
    • (2002) Biochem J , vol.361 , pp. 417-429
    • Vaz, F.M.1    Wanders, R.J.2
  • 6
    • 33744524787 scopus 로고    scopus 로고
    • Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat
    • Van Vlies N., Wanders R.J.A., and Vaz F.M. Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat. Anal Biochem 354 (2006) 132-139
    • (2006) Anal Biochem , vol.354 , pp. 132-139
    • Van Vlies, N.1    Wanders, R.J.A.2    Vaz, F.M.3
  • 7
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I., Yabuuchi H., Nezu J., Sai Y., Oku A., Shimane M., et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419 (1997) 107-111
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3    Sai, Y.4    Oku, A.5    Shimane, M.6
  • 8
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I., Ohashi R., Nezu J., Yabuuchi H., Oku A., Shimane M., et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273 (1998) 20378-20382
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3    Yabuuchi, H.4    Oku, A.5    Shimane, M.6
  • 9
    • 0034704135 scopus 로고    scopus 로고
    • Molecular and functional characterization of organic cation/carnitine transporter family in mice
    • Tamai I., Ohashi R., Nezu J.I., Sai Y., Kobayashi D., Oku A., et al. Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 275 (2000) 40064-40072
    • (2000) J Biol Chem , vol.275 , pp. 40064-40072
    • Tamai, I.1    Ohashi, R.2    Nezu, J.I.3    Sai, Y.4    Kobayashi, D.5    Oku, A.6
  • 10
    • 0029791412 scopus 로고    scopus 로고
    • PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K., Peinado-Onsurbe J., Lefebvre A.M., Heyman R.A., Briggs M., Deeb S., et al. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 15 (1996) 5336-5348
    • (1996) EMBO J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.M.3    Heyman, R.A.4    Briggs, M.5    Deeb, S.6
  • 12
    • 34548126519 scopus 로고    scopus 로고
    • Treatment with pharmacological peroxisome proliferator-activated receptor α agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    • Ringseis R., Pösel S., Hirche F., and Eder K. Treatment with pharmacological peroxisome proliferator-activated receptor α agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacol Res 56 (2007) 175-183
    • (2007) Pharmacol Res , vol.56 , pp. 175-183
    • Ringseis, R.1    Pösel, S.2    Hirche, F.3    Eder, K.4
  • 13
    • 34548151116 scopus 로고    scopus 로고
    • PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation
    • van Vlies N., Ferdinandusse S., Turkenburg M., Wanders R.J., and Vaz F.M. PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim Biophys Acta 1767 (2007) 1134-1142
    • (2007) Biochim Biophys Acta , vol.1767 , pp. 1134-1142
    • van Vlies, N.1    Ferdinandusse, S.2    Turkenburg, M.3    Wanders, R.J.4    Vaz, F.M.5
  • 14
    • 40149101595 scopus 로고    scopus 로고
    • PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis
    • Koch A., König B., Stangl G.I., and Eder K. PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp Biol Med (Maywood) 233 (2008) 356-365
    • (2008) Exp Biol Med (Maywood) , vol.233 , pp. 356-365
    • Koch, A.1    König, B.2    Stangl, G.I.3    Eder, K.4
  • 15
    • 17744366563 scopus 로고    scopus 로고
    • Absorbing competition for carnitine
    • Taylor P.M. Absorbing competition for carnitine. J Physiol 532 (2001) 283
    • (2001) J Physiol , vol.532 , pp. 283
    • Taylor, P.M.1
  • 18
    • 50649111762 scopus 로고    scopus 로고
    • National Research Council. Guide for the care and use of laboratory animals. Publication no. 85-23 (rev.). Washington, DC: National Institutes of Health; 1985.
    • National Research Council. Guide for the care and use of laboratory animals. Publication no. 85-23 (rev.). Washington, DC: National Institutes of Health; 1985.
  • 19
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet
    • Reeves P.G., Nielsen F.H., and Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J Nutr 123 (1993) 1939-1951
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey, G.C.3
  • 20
    • 0002139779 scopus 로고
    • 2 im Darminhalt und Kot nach Kjehldahlauschluß
    • 2 im Darminhalt und Kot nach Kjehldahlauschluß. Arch Anim Nutr 37 (1987) 453
    • (1987) Arch Anim Nutr , vol.37 , pp. 453
    • Brandt, M.1    Allam, S.M.2
  • 21
    • 18144441140 scopus 로고
    • Estimate of digestibility in dairy cows using an indicator method in comparison to the Hohenheimer feed value test
    • Hafez S., Junge W., and Kalm E. Estimate of digestibility in dairy cows using an indicator method in comparison to the Hohenheimer feed value test. Arch Anim Nutr 38 (1988) 929-945
    • (1988) Arch Anim Nutr , vol.38 , pp. 929-945
    • Hafez, S.1    Junge, W.2    Kalm, E.3
  • 22
    • 50649100775 scopus 로고
    • A method of indirect evaluation of the titer of absorption of phosphorus compounds at different levels of the digestive tract
    • Fournier P., and Dupuis Y. A method of indirect evaluation of the titer of absorption of phosphorus compounds at different levels of the digestive tract. J Physiol (Paris) 45 (1953) 443-449
    • (1953) J Physiol (Paris) , vol.45 , pp. 443-449
    • Fournier, P.1    Dupuis, Y.2
  • 23
    • 0027081216 scopus 로고
    • Evaluation of inert markers for the determination of ileal faecal apparent digestibility values in the pig
    • Jagger S., Wiseman J., Cole D.J.A., and Craigon J. Evaluation of inert markers for the determination of ileal faecal apparent digestibility values in the pig. Br J Nutr 68 (1992) 729-739
    • (1992) Br J Nutr , vol.68 , pp. 729-739
    • Jagger, S.1    Wiseman, J.2    Cole, D.J.A.3    Craigon, J.4
  • 24
    • 0039112845 scopus 로고
    • A comparison of techniques used in digestibility studies with dairy cattle
    • Kane E.A., Jacobson W.C., and Moore L.A. A comparison of techniques used in digestibility studies with dairy cattle. J Nutr 41 (1950) 583-596
    • (1950) J Nutr , vol.41 , pp. 583-596
    • Kane, E.A.1    Jacobson, W.C.2    Moore, L.A.3
  • 26
    • 35148877188 scopus 로고    scopus 로고
    • Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats
    • Koch A., König B., Luci S., Stangl G.I., and Eder K. Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats. Br J Nutr 98 (2007) 882-889
    • (2007) Br J Nutr , vol.98 , pp. 882-889
    • Koch, A.1    König, B.2    Luci, S.3    Stangl, G.I.4    Eder, K.5
  • 27
    • 0024822538 scopus 로고
    • Utilization of dietary precursors for carnitine synthesis in human adults
    • Rebouche C.J., Bosch E.P., Chenard C.A., Schabold K.J., and Nelson S.E. Utilization of dietary precursors for carnitine synthesis in human adults. J Nutr 119 (1989) 1907-1913
    • (1989) J Nutr , vol.119 , pp. 1907-1913
    • Rebouche, C.J.1    Bosch, E.P.2    Chenard, C.A.3    Schabold, K.J.4    Nelson, S.E.5
  • 28
    • 0025173910 scopus 로고
    • Uptake of l-carnitine by rat jejunal brush border microvillous membrane vesicles. Evidence of passive diffusion
    • Li B.U., Bummer P.M., Hamilton J.W., Gudjonsson H., Zografi G., and Olsen W.A. Uptake of l-carnitine by rat jejunal brush border microvillous membrane vesicles. Evidence of passive diffusion. Dig Dis Sci 35 (1990) 333-339
    • (1990) Dig Dis Sci , vol.35 , pp. 333-339
    • Li, B.U.1    Bummer, P.M.2    Hamilton, J.W.3    Gudjonsson, H.4    Zografi, G.5    Olsen, W.A.6
  • 29
    • 0021238167 scopus 로고
    • Absorption of d- and l-carnitine by the intestine and kidney tubule in the rat
    • Gross C.J., and Henderson L.M. Absorption of d- and l-carnitine by the intestine and kidney tubule in the rat. Biochim Biophys Acta 772 (1984) 209-219
    • (1984) Biochim Biophys Acta , vol.772 , pp. 209-219
    • Gross, C.J.1    Henderson, L.M.2
  • 31
    • 0036146331 scopus 로고    scopus 로고
    • Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels
    • Slitt A.L., Cherrington N.J., Hartley D.P., Leazer T.M., and Klaassen C.D. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab Dispos 30 (2002) 212-219
    • (2002) Drug Metab Dispos , vol.30 , pp. 212-219
    • Slitt, A.L.1    Cherrington, N.J.2    Hartley, D.P.3    Leazer, T.M.4    Klaassen, C.D.5
  • 32
    • 33747618018 scopus 로고    scopus 로고
    • Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse
    • Kato Y., Sugiura M., Sugiura T., Wakayama T., Kubo Y., Kobayashi D., et al. Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Mol Pharmacol 70 (2006) 829-837
    • (2006) Mol Pharmacol , vol.70 , pp. 829-837
    • Kato, Y.1    Sugiura, M.2    Sugiura, T.3    Wakayama, T.4    Kubo, Y.5    Kobayashi, D.6
  • 33
  • 34
    • 0034842137 scopus 로고    scopus 로고
    • Carnitine transport by organic cation transporters and systemic carnitine deficiency
    • Lahjouji K., Mitchell G.A., and Qureshi I.A. Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol Genet Metab 73 (2001) 287-297
    • (2001) Mol Genet Metab , vol.73 , pp. 287-297
    • Lahjouji, K.1    Mitchell, G.A.2    Qureshi, I.A.3
  • 35
    • 0032953645 scopus 로고    scopus 로고
    • Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    • Nezu J., Tamai I., Oku A., Ohashi R., Yabuuchi H., Hashimoto N., et al. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21 (1999) 91-94
    • (1999) Nat Genet , vol.21 , pp. 91-94
    • Nezu, J.1    Tamai, I.2    Oku, A.3    Ohashi, R.4    Yabuuchi, H.5    Hashimoto, N.6
  • 36
    • 0034212998 scopus 로고    scopus 로고
    • Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta
    • Wu X., George R.L., Huang W., Wang H., Conway S.J., Leibach F.H., et al. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta 1466 (2000) 315-327
    • (2000) Biochim Biophys Acta , vol.1466 , pp. 315-327
    • Wu, X.1    George, R.L.2    Huang, W.3    Wang, H.4    Conway, S.J.5    Leibach, F.H.6
  • 37
    • 33744801418 scopus 로고    scopus 로고
    • Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria
    • Lamhonwah A.M., and Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun 345 (2006) 1315-1325
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1315-1325
    • Lamhonwah, A.M.1    Tein, I.2
  • 38
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15 (1995) 3012-3022
    • (1995) Mol Cell Biol , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6
  • 40
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • Bremer J. Carnitine-metabolism and functions. Physiol Rev 63 (1983) 1420-1480
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 41
    • 0037404708 scopus 로고    scopus 로고
    • Effect of l-carnitine supplementation on cardiac carnitine palmitoyltransferase activities and plasma carnitine concentrations in adriamycin-treated rats
    • Yoon H.R., Hong Y.M., Boriack R.L., and Bennett M.J. Effect of l-carnitine supplementation on cardiac carnitine palmitoyltransferase activities and plasma carnitine concentrations in adriamycin-treated rats. Pediatr Res 53 (2003) 788-792
    • (2003) Pediatr Res , vol.53 , pp. 788-792
    • Yoon, H.R.1    Hong, Y.M.2    Boriack, R.L.3    Bennett, M.J.4
  • 42


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