Effect of L-carnitine supplementation on cardiac carnitine palmitoyltransferase activities and plasma carnitine concentrations in adriamycin-treated rats

Pediatric Research

Volumn 53, Issue 5, 2003, Pages 788-792

  Yoon, Hye Ran ^a   Hong, Young Mi ^b,d   Boriack, Richard L ^c   Bennett, Michael J ^c  

^a Seoul Medical Science Institute   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; CARNITINE PALMITOYLTRANSFERASE; DOXORUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG ACCUMULATION; DRUG EFFECT; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIPID STORAGE; MALE; MEMBRANE POTENTIAL; MICROSOME MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARDIOMYOPATHIES; CARNITINE; CARNITINE O-PALMITOYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME ACTIVATION; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037404708     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000057988.62605.13     Document Type: Article

References (32)

1. Singal PK, Siveski-Iliskovic N, Hill M, Thomas PT, Li T 1995 Combination therapy with probucol prevents adriamycin-induced cardiomyopathy. J Mol Cell Cardiol 27:1055-1063
2. Link G, Tirosh R, Pinson A, Hershko C 1996 Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction. J Lab Clin Med 27:272-278
3. Doroshow JH 1983 Effect of anthracycline antibiotics on oxygen radical formation in rat heart. Cancer Res 43:460-472
4. Rajagopalan S, Politi PM, Sinha BK, Meyers CE 1988 Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res 48:4766-4769
5. Mimnaugh EG, Trush MA, Gram TE 1983 Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo. Cancer Treat Rep 67:731-733
6. Lampidis TJ, Johnson LV, Israel M 1981 Effects of adriamycin on rat heart cells in culture: increased accumulation and nucleoli fragmentation in cardiac muscle v. non-muscle cells. J Mol Cell Cardiol 13:913-924
7. Torti SV, Akimoto H, Lin K, Billingham ME, Torti FM 1998 Selective inhibition of muscle gene expression by oxidative stress in cardiac cells. J Mol Cell Cardiol 30:1173-1180
8. Arai M, Tomaru K, Takizaua T, Sekiguchi K, Yokoyama T, Suzuki T, Nagai R 1998 Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubucin in rabbits. J Mol Cell Cardiol 30:243-254
9. Iliskovic N, Singal PK 1997 Lipid lowering: an important factor in preventing adriamycin-induced heart failure. Am J Pathol 150:727-734
10. Abdel-aleem S, El-Merzabani MM, Sayed-Ahmed M, Taylor DA, Lowe JE 1997 Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. J Mol Cell Cardiol 29:789-797
11. Iliskovic N, Li T, Khaper N, Palace V, Singal PK 1998 Modulation of adriamycin-induced changes in serum free fatty acids, albumin and cardiac oxidative stress. Mol Cell Biochem 188:161-166
12. Bordoni A, Baigi PL, Hrelia S 1999 The impairment of essential fatty acid metabolism as a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochim Biophys Acta 1440:100-106
13. Sayed-Ahmed MM, Sharawy S, Shouman SA, Osman AM 1999 Reversal of doxorubicin-induced cardiac metabolic damage by L-carnitine. Phamacol Res 39:289-295
14. Hong YM, Kim HS, Yoon HR 2002 Serum lipid and fatty acid profiles in adriamycininduced cardiomyopathy after administration of L-carnitine. Pediatr Res 51:249-255
15. Bressler R, Gay R, Copeland JG, Bahl JJ, Bedotto J, Goldman S 1989 Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction. Life Sci 44:1897-1906
16. Corr PB, Gross RW, Sobel BE 1984 Amphipathic metabolites and membrane dysfunction in ischemic myocardium. Circ Res 55:135-154
17. Brady LJ, Brady PS 1987 Hepatic and cardiac carnitine palmitoyltransferase activity: effects of adriamycin and galactosamine. Biochem Pharmacol 36:3419-3423
18. Kashfi K, Israel M, Sweatman TW, Seshadri R, Cook GA 1990 Inhibition of mitochondrial carnitine palmitoyltransferases by adriamycin and adriamycin analogues. Biochem Pharmacol 40:1441-1448
19. Hong YM, Kim SS 1998 The role of apoptosis in adriamycin induced cardiotoxicity and preventive effect of L-carnitine in rat. J Korean Pediatr Soc 41:760-768
20. Esser V, Brown NF, Cowan AT, Foster DW, McGarry JD 1996 Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). J Biol Chem 271:6972-6977
21. Lowry OH, Rosebrough NJ, Farr A, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
22. Takahashi M, Ueda S, Misaki H, Sugiyama N, Matsumoto K, Matsuo N. Murao S 1994 Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase. Clin Chem 40:817-821
23. Winter SC, Bruist NRM 2000 The role of energy metabolism defects in cardiomyopathy: from inborn errors to ischemia - cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine. Am Heart J 139:63-69
24. Treem WR, Stanley CA, Finegold DN, Hale DE, Coates PM 1988 Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts. N Engl J Med 319:1331-1336
25. Winter SC, Szabo-Aczel S, Curry CJR, Hutchinson HT, Hogue R, Shug AL 1987 Plasma carnitine deficiency: clinical observations in 51 pediatric patients. Am J Dis Child 141:660-665
26. Regitz V, Shug AL, Fleck E 1990 Defective myocardial carnitine metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary, hypertensive and'valvular heart disease. Am J Cardiol 65:755-760
27. Kawasaki N, Lee JD, Shimizu H, Ishii Y, Ueda T 1996 Cardiac energy metabolism stages of adriamycin-induced heart failure in rats. Int J Cardiol 55:217-225
28. Waber LJ, Valle D, Neill C, DiMauro S Shug A 1982 Carnitine deficiency presenting as familial cardiomyopathy: a treatable defect in carnitine transport. J Pediatr 101:700-708
29. Strauss M, Anselmi G, Hermoso T, Tejero F 1998 Carnitine promotes heat shock protein synthesis in adriamycin-induced cardiomyopathy in a neonatal rat experimental model. J Mol Cell Cardiol 30:2319-2325
30. Millington DS, Roe CR, Maltby DA 1984 Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease. Biomed Mass Spectrom 11:236-241
31. Millington DS, Bohan TP, Roe CR, Yergey AL, Liberato DJ 1985 Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. Clin Chim Acta 15:145;69-76
32. Vickers S, Duncan CA, White SD, Ramjit HG, Smith JL, Walker RW, Flynn H, Arison BH 1985 Carnitine and glucuronic acid conjugates of pivalic acid. Xenobiotica 15:453-458