The myosin power stroke

Cell Motility and the Cytoskeleton

Volumn 51, Issue 1, 2002, Pages 1-15

  Tyska, Matthew J ^a   Warshaw, David M ^a,b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Actin; Myosin; Optical trap; Single molecule assay

Indexed keywords

ADENOSINE TRIPHOSPHATASE; MYOSIN; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN;

ACTIN FILAMENT; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DATA ANALYSIS; DICTYOSTELIUM DISCOIDEUM; GEOMETRY; IMAGE RECONSTRUCTION; MOLECULAR DYNAMICS; MOTOR UNIT; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL NOISE RATIO;

ANIMALS; MOLECULAR MOTOR PROTEINS; MUSCLE CONTRACTION; MYOSINS; PROTEIN STRUCTURE, SECONDARY;

EID: 0036152427     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/cm.10014     Document Type: Review

References (101)

1. Myosin motors with artificial lever arms
2. A large and distinct rotation of the myosin light chain domain occurs upon muscle contraction
3. ATPase activity of myosin correlated with speed of muscle shortening
4. A millennial myosin census
5. Luminescence resonance energy transfer measurements in myosin
6. Single-headed myosin II acts as a dominant negative mutation in Dictyostelium
7. Calmodulin dissociation regulates brush border myosin I (110-kD calmodulin) mechanochemical activity in vitro
8. Cooperativity between the two heads of rabbit skeletal muscle heavy meromyosin in binding to actin
9. Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction
10. Interaction of actin and ADP with the head domain of smooth muscle myosin: Implications for strain-dependent ADP release in smooth muscle
11. Kinetic mechanism of chicken brain myosin-V
12. The kinetic mechanism of myosin V
13. Kinetic mechanism and regulation of myosin VI
14. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre- power stroke state
15. Single myosin molecule mechanics: Piconewton forces and nanometre steps
16. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.A1F4-
17. Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cells
18. Myosin and adaptation by hair cells
19. Kinetics of the actomyosin ATPase in muscle fibers
20. ADP release produces a rotation of the neck region of smooth myosin but not skeletal myosin
21. Smooth muscle and skeletal muscle myosins produce similar unitary forces and displacements in the laser trap
22. Smooth and skeletal muscle myosin both exhibit low duty cycles at zero load in vitro
23. Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro
24. Relationships between chemical and mechanical events during muscular contraction
25. Phosphate release and force generation in skeletal muscle fibers
26. Heavy meromyosin binds actin with negative cooperativity
27. Factors affecting movement of F-actin filaments propelled by skeletal muscle heavy meromyosin
28. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: A novel conformation of the myosin head
29. Three conformational states of scallop myosin S1
30. Is the lever arm of myosin a molecular elastic element?
31. Pulling springs to tune transduction: Adaptation by hair cells
32. Muscle structure and theories of contraction
33. Proposed mechanism of force generation in striated muscle
34. Filament compliance and tension transients in muscle
35. Sliding filaments and molecular motile systems
36. Crossbridge behaviour during muscle contraction
37. Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle
38. Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin
39. Cooperativity between two heads of dictyostelium myosin II in in vitro motility and ATP hydrolysis
40. Brush border myosin-I structure and ADP-dependent conformational changes revealed by cryoelectron microscopy and image analysis
41. A 32 degree tail swing in brush border myosin I on ADP release
42. Kinetic characterization of brush border myosin-I ATPase
43. Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding
44. Glycine 699 is pivotal for the motor activity of skeletal muscle myosin
45. A single myosin head moves along an actin filament with regular steps of 5.3 nanometres
46. Force of single kinesin molecules measured with optical tweezers
47. Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins. Transient kinetic analysis of S1 isoforms
48. A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap
49. Coiled-coil unwinding at the smooth muscle myosin head-rod junction is required for optimal mechanical performance
50. Skeletal muscle myosin light chains are essential for physiological speeds of shortening
51. Mechanism of adenosine triphosphate hydrolysis by actomyosin
52. Substructure of the myosin molecule. IV. Interactions of myosin and its subfragments with adenosine triphosphate and F-actin
53. Interaction of myosin subfragments with F-actin
54. Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate muscles
55. Myosin learns to walk
56. Detection of single-molecule interactions using correlated thermal diffusion
57. Myosin-V is a processive actin-based motor
58. Unconventional myosins in cell movement, membrane traffic, and signal transduction
59. Movement and force produced by a single myosin head
60. Myosin V exhibits a high duty cycle and large unitary displacement
61. Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates
62. The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actinmyosin ATPase cycle and its maximum ATPase activity
63. Intradomain distances in the regulatory domain of the myosin head in prepower and postpower stroke states: Fluorescence energy transfer
64. Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoforms
65. Sequence variations in the surface loop near the nucleotide binding site modulate the ATP turnover rates of molluscan myosins
66. Three-dimensional structure of myosin subfragment-1: A molecular motor
67. Visualizing myosin's power stroke in muscle contraction
68. Myosin-V stepping kinetics: A molecular model for processivity
69. A long, weakly charged actin-binding loop is required for phosphorylation-dependent regulation of smooth muscle myosin
70. An insert in the motor domain determines the functional properties of expressed smooth muscle myosin isoforms
71. Single-molecule tracking of myosins with genetically engineered amplifier domains
72. A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin
73. ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle
74. X-ray structure of the magnesium(I-I).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9. A resolution
75. How molecular motors work
76. Swing of the lever arm of a myosin motor at the isomerization and phosphate-release steps
77. Direct observation of kinesin stepping by optical trapping interferometry
78. Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide binding pocket
79. Orientation dependence of displacements by a single one-headed myosin relative to the actin filament
80. 2+-activated contracting insect flight muscle
81. Two heads of myosin are better than one for generating force and motion
82. Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin
83. Quantized velocities at low myosin densities in an in vitro motility assay
84. Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin
85. The neck region of the myosin motor domain acts as a lever arm to generate movement
86. The essential light chain is required for full force production by skeletal muscle myosin
87. Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro
88. The stiffness of rabbit skeletal actomyosin cross-bridges determined with an optical tweezers transducer
89. The motor protein myosin-I produces its working stroke in two steps
90. Mechanical properties of single myosin V molecules
91. Single kinesin molecules studied with a molecular force clamp
92. Two-headed binding of a processive myosin to F-actin
93. A minimal motor domain from chicken skeletal muscle myosin
94. Effects of MgATP, MgADP, and Pi on actin movement by smooth muscle myosin
95. The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever
96. Calcium-calmodulin and regulation of brush border myosin-I MgATPase and mechanochemistry
97. Conformational changes between the active-site and regulatory light chain of myosin as determined by luminescence resonance energy transfer: The effect of nucleotides and actin
98. ADP inhibits the sliding velocity of fluorescent actin filaments on cardiac and skeletal myosins
99. 2+ binding sites of calmodulin are critical for the regulation of myosin Ibeta motor function