Modulatory effect of naringenin on N-methyl-N′-nitro-N- nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male wistar rats

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 10, 2008, Pages 1190-1196

  Ganapathy, Ekambaram ^a   Peramaiyan, Rajendran ^a   Rajasekaran, Devaraja ^a   Venkataraman, Magesh ^a   Dhanapal, Sakthisekaran ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Gastric cancer; N methyl N nitro N nitrosoguanidine; Naringenin; Oxidative stress; Wistar rat

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; METHYLNITRONITROSOGUANIDINE; NARINGENIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; LIPID PEROXIDATION; MALE; METABOLIC REGULATION; NONHUMAN; OXIDATIVE STRESS; RAT; REGULATORY MECHANISM; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ENZYME ACTIVATION; FLAVANONES; LIPID PEROXIDATION; MALE; METHYLNITRONITROSOGUANIDINE; MICROSOMES, LIVER; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SODIUM CHLORIDE; STOMACH NEOPLASMS;

EID: 50649083268     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04987.x     Document Type: Article

References (56)

1. Rivera F, Vega-Villegas MA, Lopez-Brea MF. Chemotherapy of advanced gastric cancer. Cancer Treat. Rev. 2007 33 : 315 24.
2. Sato T, Fukuyama T, Suzuki T et al. The relationship between gastric cancer mortality rate and salted food intake in several places in Japan. Bull. Inst. Public Health 1959 8 : 187 98.
3. Nomura AM, Hankin JH, Kolonel LN, Wilkens LR, Goodman MT, Stemmermann GN. Case-control study of diet and other risk factors for gastric cancer in Hawaii. Cancer Causes Control 2003 14 : 547 58.
4. Bartsch H, Ohshima H, Pignatelli P, Calmels S. Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiology. Pharmacogenetics 1992 2 : 272 7.
5. Tatsuta M, Iishi H, Baba M, Yano H, Uehara H, Nakaizumi A. Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats. Int. J. Cancer 1999 80 : 396 9.
6. Arivazhagan S, Balasenthil S, Nagini S. Chemopreventive potential of garlic and neem during gastric carcinogenesis induced by N-methyl-N9-nitro-N- nitrosoguanidine. Med. Sci. Res. 1999 27 : 209 12.
7. Stadtländer CT, Waterbor JW. Molecular epidemiology, pathogenesis and prevention of gastric cancer. Carcinogenesis 1999 20 : 2195 208.
8. Johnson IT. Plant anticarcinogens. Eur. J. Cancer Prev. 1997 6 : 515 17.
9. Farber JL, Gerson RJ. Mechanisms of cell injury with hepatotoxic chemicals. Pharmacol. Rev. 1984 36 (Suppl. 2 S71 5.
10. Spiteller G. Enzymic lipid peroxidation: A consequence of cell injury? Free Radic. Biol. Med. 1996 21 : 1003 9.
11. Scalbert A, Manach C, Morand C et al. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 2005 45 : 287 306.
12. Lee H, Yeom H, Kim YG et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem. Pharmacol. 1998 55 : 1369 75.
13. Lautraite S, Musonda AC, Doehmer J, Edwards GO, Chipman JK. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002 17 : 45 53.
14. Gonzalez FJ, Gelboin HV. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 1994 26 : 165 83.
15. Kroyer G. The antioxidant activity of citrus fruit peels. Z. Eranhrungswissenschaft 1986 25 : 63 9.
16. So FV, Guthrie N, Chambers AF et al. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr. Cancer 1996 26 : 167 81.
17. Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, Huff MW. Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry 2003 42 : 1283 91.
18. Kanno S, Tomizawa A, Hiura T et al. Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice. Biol. Pharm. Bull. 2005 28 : 527 30.
19. Pick E, Keisari Y. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages: Induction by multiple nonphagocytic stimuli. Cell Immunol. 1981 59 : 301 18.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979 95 : 351 8.
21. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin's phenol reagent. J. Biol. Chem. 1951 193 : 265 76.
22. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 1969 27 : 502 22.
23. Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 1980 106 : 207 12.
24. Massey V, Williams Jr CH. On the reaction mechanism of yeast glutathione reductase. J. Biol. Chem. 1965 240 : 4470 80.
25. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical roles as a component of glutathione peroxidase. Science 1973 179 : 588 90.
26. Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases, the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974 249 : 7130 9.
27. Dror Y, Sassoon HF, Watson JJ, Johnson BC. Glucose 6-phosphate dehydrogenase assay in liver and blood. Clin. Chim. Acta 1970 28 : 291 8.
28. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 1964 239 : 2370 8.
29. Williams Jr CH, Kamin H. Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver. J. Biol. Chem. 1962 237 : 587 95.
30. Andersson T, Pesonen M, Johansson C. Differential induction of cytochrome P-450-dependent monooxygenase, epoxide hydrolase, glutathione transferase and UDP glucuronosyl transferase activities in the liver of the rainbow trout by beta-naphthoflavone or Clophen A50. Biochem. Pharmacol. 1985 34 : 3309 14.
31. Luna LG. Manual of Histological Staining. Methods of Armed Forces. Institute of Pathology, London. 1966.
32. Sun Y, Oberley LW. Redox regulation of transcriptional activators. Free Radic. Biol. Med. 1996 21 : 335 48.
33. Blackburn RV, Spitz DR, Liu X et al. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic. Biol. Med. 1999 26 : 419 30.
34. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: Review of epidemiological evidence. Gastric Cancer 2007 10 : 75 83.
35. Block G, Patterson B, Subar A. Fruit and vegetables, and cancer prevention: A review of epidemiological evidence. Nutr. Cancer 1992 18 : 1 29.
36. Thirunavukkarasu C, Prince Vijeya Singh J, Thangavel M, Selvendiran K, Sakthisekaran D. Dietary influence of selenium on the incidence of N-nitrosodiethylamine-induced hepatoma with reference to drug and glutathione metabolizing enzymes. Cell Biochem. Funct. 2002 20 : 347 56.
37. Kumar MS, Unnikrishnan MK, Patra S, Murthy K, Srinivasan KK. Naringin and naringenin inhibit nitrite-induced methemoglobin formation. Pharmazie 2003 58 : 564 6.
38. Velmurugan B, Nagini S. Combination chemoprevention of experimental gastric carcinogenesis by S-allylcysteine and lycopene: Modulatory effects on glutathione redox cycle antioxidants. J. Med. Food 2005 8 : 494 501.
39. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA 1993 90 : 7915 22.
40. Breimer LH. Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of DNA base damage. Mol. Carcinog. 1995 3 : 188 97.
41. Sandstrom BE, Marklund SL. Effects of variation in gluthathione peroxidase activity on DNA damage and cell survival in human cells exposed to hydrogen peroxide and t-butyl hydroperoxide. Biochem. J. 1990 271 : 17 23.
42. 2-induced DNA damage and inhibition of protein synthesis in endothelial cells. J. Cell Physiol. 1991 149 : 408 13.
43. Mullineaux P, Creissen GP. Glutathione reductase: Regulation and role in oxidative stress. In : Scandalios JG (ed.). Oxidative Stress and the Molecular Biology of Antioxidant Defenses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. 1997 667 713.
44. Vanoni MA, Wong KK, Ballou DP. Glutathione reductase: Comparison of steady state and rapid reaction primary kinetic isotope effects exhibited by the yeast spinach and Escherichia coli enzymes. Biochemistry 1991 29 : 5790 6.
45. Meister A. Glutathione. In : Arias IM, Boyer JL, Jakoby WB, Fausto D, Schacter D, Shafritz DA (eds). The Liver. Biology and Pathobiology. Raven Press, New York. 1994 401 17.
46. Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN. Catalase and glutathione peroxidase are equally effective in detoxification of hydrogen peroxide in human erythrocytes. Blood 1989 73 : 334 9.
47. Banki K, Hutter E, Gonchoroff NJ, Perl A. Molecular ordering in HIV-induced apoptosis. Oxidative stress, activation of caspases, and cell survival are regulated by transaldolase. J. Biol. Chem. 1998 273 : 11 944 53.
48. Lee YJ, Galoforo SS, Berns CM et al. Glucose deprivation-induced cytotoxicity and alterations in mitogenactivated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. J. Biol. Chem. 1998 273 : 5294 9.
49. Slaga TJ. Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds. Crit. Rev. Food Sci. Nutr. 1995 35 : 51 7.
50. Hartman PE, Shankel DW. Antimutagens and anticarcinogens; a survey of putative interceptor molecules. Environ. Mol. Mutagen. 1990 15 : 145 82.
51. Reed DJ. Glutathione: Toxicological implications. Annu. Rev. Pharmacol. Toxicol. 1990 30 : 603 31.
52. Mantovani G, Maccio A, Madeddu C et al. Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: Correlation with stage and performance status. Int. J. Cancer 2002 98 : 84 91.
53. Halliwell B, Gutteridge JMC. Protection against oxidants in biological systems. Superoxide theory of oxygen toxicity. In : Halliwell B, Gutteridge JMC (eds). Free Radicals in Biology and Medicine. Clarendon Press, Oxford. 1989 144 7.
54. Will ED. Lipid peroxide formation in microsomes. Biochem. J. 1969 113 : 333 41.
55. 450. Arch. Toxicol. 1972 29 : 219 33.
56. Dasgupta T, Banejee S, Yadav PK, Rao AR. Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis. Mol. Cell. Biochem. 2001 226 : 27 38.