Moderate physical training increases brain insulin concentrations in experimental diabetic rats

Indian Journal of Experimental Biology

Volumn 46, Issue 6, 2008, Pages 443-446

  De Almeida Leme, J A C ^a   Gomes, Ricardo José ^a   De Mello, Maria Alice Rostom ^a   Luciano, Eliete ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Brain; Diabetes; Insulin; Physical training; Rat

Indexed keywords

ANIMALIA; RATTUS;

GLYCOGEN; INSULIN;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; PHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BRAIN; DIABETES MELLITUS, EXPERIMENTAL; GLYCOGEN; INSULIN; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR;

EID: 50449088266     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Bruning J C, Gautam D, Burks D J, Gillette J, Schubert M, Orban P C, Klein R, Krone W, Muller-Wieland D & Kahn C R, Role of brain insulin receptor in control of body weight and reproduction, Science, 22 (2000) 2122.
2. Kaiyala K J, Prigeon R L, Kahn S E, Woods S C & Schwartz M W, Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs, Diabetes, 49 (2000) 1525.
3. Gerozessis K, Brain insulin and feeding: A bi-directional communication, Eur J Pharmacol, 490 (2004) 59.
4. Gerozissis K, Brain insulin: Regulation, mechanisms of action and functions, cellular and molecular, Neurobiology, 23 (2003) 1.
5. Gerozissis K, Rouch C, Lemierre S, Nicolaydis S & Orosco M A, Potential role of central insulin in learning and memory related to feeding, Cell Mol Neurobiol 21 (2001) 389.
6. Havrankova J, Roth J & Brownstein M J, Concentrations of insulin and of insulin receptors in the brain are independent of peripheral insulin levels, Clin Invest 64 (1979) 636.
7. Biessels G J, Van der Heide L P, Kamal A, Bleys R L A & Gispen W H, Aging and diabetes: Implications for brain function, Eur J Pharmacol, 441 (2002) 1.
8. De la Monte S M & Wands J R, Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease, J Alzheimers Dis, 7 (2005) 45.
9. Lester-Coll N, Rivera E J, Soscia S J, Doiron K, Wands J R & de la Monte SM, Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease, J Alzheimers Dis, 9 (2006) 13.
10. Pardridge W M, Eisenberg J & Yang J, Human blood-brain barrier insulin receptor, J Neurochem, 44 (1985) 1771.
11. Baskin D G, Stein L J, Ikeda H, Woods S C, Figlewicz D P & Porte D Jr, Genetically obese Zucker rats have abnormally low brain insulin content, Life Sci, 36 (1985) 627.
12. Craft S, Peskind E, Schwartz M W, Schellenberg G D, Raskind M & Porte D Jr, Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype, Neurology, 50 (1998) 164.
13. Zahm D S, Insulin gene expression and insulin synthesis in mammalian neuronal cells, J Biol Chem, 269 (1994) 8445.
14. nd European Winter Conference on Brain Research Meeting abstracts, (2002) 1800.
15. Park C R, Seeley R J, Craft S & Woods S C, Intracerebroventricular insulin enhances memory in a passive-avoidance task, Physiol Behav, 68 (2000) 509.
16. Nogueira D A, Strufaldi B, Hirata M H, Abdalla D S P, Hirata R D C, Saugue-parte I: Glici'dios in Métodos de bioquímica Clínica, editora Pancast, (1990) 153.
17. Nogueira D A, Strufaldi B, Hirata M H, Abdalla D S P, Hirata R D C, Saugue-parte I: Glici'dios in Métodos de bioquímica Clínica, editora Pancast, (1990) 153. 17 Siu L O, Russeau J C & Taylor A W, Determination of glycogen in small tissue samples. J Appl Physiol (1970) 28(2): 234.
18. Craft S, Asthana S, Cook D G, Baker L D, Cherrier M & Purganan K, Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: Interactions with apolipoprotein E genotype, Psychoneuroendocrinology 28 (2003) 809-822
19. Steen E, Terry B M, Rivera E J, Cannon J L, Neely T R, Tavares R, Xu XJ, Wands JR & de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis 7(1) (2005) 63-80.
20. Farrel P A, Fedele M J, Hernandez J, Fluckey J D, Miller J L, Lang C H, Vary T C, Kimball S R & Jefferson L S, Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise, J Appl Physiol, 87 (1999) 1075.
21. Gomes R J, Mello M A R, Caetano F H, Sibuya C Y, Anaruma C A, Rogatto G P, Pauli J R & Luciano E, Effects of swimming training on bone mass and the GH/IGF-1 axis in diabetic rats. Growth Horm IGF Res, 16(5-6) (2006) 326.
22. Lim G J, Kang H J & Stewart K J, Type 2 diabetes in Singapore: the role of exercise training for its prevention and management, Singapore Med J, 45 (2004) 62.
23. Manetta J, Brun J F, Maimoun L, Callis A, Préfaut C & Mercier J, Effect of training on the GH/IGF-1 axis during exercise in middle-aged men: Relationship to glucose homeostasis, Am J Physiol Endocrinol Metab, 283 (2002) E929.
24. Luciano E, Carneiro E M, Carvalho C R O, Carvalheira J B C, Peres S B, Reis M A B, Saad M J A, Boschero A C & Velloso L A, Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol, 147 (2002) 149.
25. Wojtaszewski J F P, Nielsen J N & Richter E A, Exercise effects on muscle insulin signaling and action: Effect of acute exercise on insulin signaling and action in humans, J Appl Physiol, 93 (2002) 384.
26. Abrass C K, Diabetic Proteinuria. Am J Nephrol, 4 (1984) 337.
27. Leme J A C A, Silveira R F & Luciano E, Efeitos da atividade física em parâmetros metabólicos de ratos diabéticos, Braz J Sci Mov, 14 (2006) S99.
28. Witters L A & Avruch J, Insulin Regulation of Hepatic Glycogen Synthase and Phosphorylase, Biochemistry, 17 (1978) 406.
29. Petersen K F, Laurent D, Rothman D L, Cline G W & Shulman G I, Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans, J Clin Invest, 101 (1998) 1203.
30. Galbo H, Saugmann P & Richter E A, Increased hepatic glycogen synthetase and decreased phosphorylase in trained rats, Acta Physiol Scand, 107 (1979) 269.
31. Wallum B J, Taborsky G J Jr, Porte D Jr, Figlewicz D P, Jacobson L, Beard J C, Ward W K & Dorsa D, Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man, J Clin Endocrinol Metab, 64 (1987) 190.
32. De La Monte S M & Watson G S, Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease, J Alzheimers Dis, 7 (2005) 45.
33. Kiraly M A & Kiraly S J, The effect of exercise on hippocampal integrity: Review of recent research, Int J Psychiatry Méd, 35 (2005) 75.
34. Nelson P G, Activity-dependent synapse modulation and the pathogenesis of Alzheimer disease, Curr Alzheimer Res, 2 (2005) 497.