Quantification of [11C]GB67 binding to cardiac α1-adrenoceptors with positron emission tomography: Validation in pigs

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 35, Issue 9, 2008, Pages 1624-1635

  Park Holohan, So Jin ^a   Asselin, Marie Claude ^a,b   Turton, David R ^a   Williams, Sharron L ^a   Hume, Susan P ^a   Camici, Paolo G ^a   Rimoldi, Ornella E ^a,c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

1 Adrenoceptors; 11C GB67; Myocardium; Pig; Positron emission tomography (PET)

Indexed keywords

[N2 6 [(4 AMINO 6,7 DIMETHOXY 2 QUINAZOLINYL)(METHYL)AMINO]HEXYL N2 METHYL 2 FURAMIDE] C 11; ALPHA 1 ADRENERGIC RECEPTOR; CARBON MONOXIDE O 15; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG; WATER O 15; CARBON; CARBON MONOXIDE; DRUG DERIVATIVE; N2 (6 ((4 AMINO 6 7 DIMETHOXY 2 QUINAZOLINYL)(METHYL)AMINO)HEXYL) N2 METHYL 2 FURAMIDE; N2-(6-((4-AMINO-6-7-DIMETHOXY-2-QUINAZOLINYL)(METHYL)AMINO)HEXYL)-N2-METHYL-2-FURAMIDE; PRAZOSIN; WATER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VOLUME; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG UPTAKE; HEART; HEART LEFT VENTRICLE; HEART MUSCLE PERFUSION; MAMMAL; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RECEPTOR DENSITY; SWINE; VALIDATION STUDY; ANIMAL; ARTERY; BLOOD; CYTOLOGY; HEART MUSCLE; HEART VENTRICLE; KINETICS; METABOLISM; PROTEIN BINDING;

ANIMALS; ARTERIES; CARBON MONOXIDE; CARBON RADIOISOTOPES; HEART VENTRICLES; KINETICS; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; PRAZOSIN; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1; SWINE; WATER;

EID: 50449084482     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0805-2     Document Type: Article

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