Evaluation of [11C]GB67, a novel radioligand for imaging myocardial (α1-adrenoceptors with positron emission tomography

European Journal of Nuclear Medicine

Volumn 27, Issue 1, 2000, Pages 7-17

  Law, Marilyn P ^a   Osman, Safiye ^a   Pike, Victor W ^a   Davenport, Raymond J ^a   Cunningham, Vincent J ^a   Rimoldi, Ornella ^a   Rhodes, Christopher G ^a   Giardinà, Dario ^b   Camici, Paolo G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Autonomic nervous system; Heart, rat and human; Positron emission tomography; 11C GB67, rat and human; 1 Adrenoceptor radioligand, GB67

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG METABOLITE; GB 67; GB 67 CARBON C 11; GB 99; HEART RECEPTOR; PHENTOLAMINE; PRAZOSIN; PRODRUG; RADIOLIGAND; UNCLASSIFIED DRUG; (C11)GB 67; CARBON; DIAGNOSTIC AGENT; FURAN DERIVATIVE; QUINAZOLINE DERIVATIVE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BINDING COMPETITION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG UPTAKE; HEART MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NONHUMAN; NORMAL HUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; RECEPTOR AFFINITY; ANIMAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; HEART; METABOLISM; MIDDLE AGED; SCINTISCANNING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ADULT; ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FURANS; HEART; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033621682     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00006665     Document Type: Article

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