Quantification of β-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model

European Journal of Nuclear Medicine

Volumn 29, Issue 3, 2002, Pages 295-304

  Doze, Petra ^a   Elsinga, Philip H ^a   Van Waarde, Aren ^a   Pieterman, Remge M ^a   Pruim, Jan ^a   Vaalburg, Willem ^a   Willemsen, Antoon T M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Adrenoceptor; PET; Receptor density; Tracer kinetic model

Indexed keywords

BETA ADRENERGIC RECEPTOR; CGP 12388; CGP 12388 C 11; HEART RECEPTOR; RADIOLIGAND; TRACER; UNCLASSIFIED DRUG;

ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CANNULA; COMPARTMENT MODEL; CONTROLLED STUDY; FEMALE; HEART; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIAL ARTERY; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY;

ADULT; BENZIMIDAZOLES; CARBON RADIOISOTOPES; COMPUTER SIMULATION; FEMALE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; MYOCARDIUM; NONLINEAR DYNAMICS; RECEPTORS, ADRENERGIC, BETA; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036195276     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-001-0714-0     Document Type: Article

References (35)

1. Peripheral adrenergic receptors in hypertension
2. Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes
3. Diffuse reduction of myocardial beta-adrenoceptors in hypertrophic cardiomyopathy: A study with positron emission tomography
4. 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy
5. Pulmonary and cardiac beta-adrenoceptor density in vivo in asthmatic subjects
6. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177, and a new graphical method
7. 11C)-one (CGP12177)
8. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography
9. Experimental design optimisation: Theory and application to estimation of receptor model parameters using dynamic positron emission tomography
10. Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration
11. 18F]fluoro-CGP 12388) for visualization of beta-adrenoceptors with positron emission tomography
12. Identifiability analysis and parameter identification of an in vivo ligand-receptor model from PET data
13. Concept of reaction volume in the in vivo ligand-receptor model
14. Intracellular inorganic ions in cardiac tissue
15. An interior, trust region approach for nonlinear minimization subject to bounds
16. On the convergence of reflective Newton methods for large-scale nonlinear minimization subject to bounds
17. Error analysis on parameter estimates in the ligand-receptor model: Application to parameter imaging using PET data
18. Comparison of two compartmental models for describing receptor ligand kinetics and receptor availability in multiple injection PET studies
19. 18F]fluoroethyl)spiperone and dynamic positron emission tomography
20. 18F]fluoroethyl)spiperone examined with positron emission tomography
21. 11C]flumazenil kinetics studied by PET: Application to a critical study of the equilibrium approaches
22. 18F]cyclofoxy and positron emission tomography
23. Modeling neuroreceptor binding of radioligands in vivo
24. 3H]CGP-12177 for resolving subtype-selectivity of competitive ligands
25. In vivo quantification of myocardial muscarinic receptors in heart transplant patients
26. Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy
27. Non-invasive regional assessment of human cardiac beta adrenoceptors (bAR)
28. Myocardial beta-adrenoceptor density and plasma catecholamines in syndrome X
29. In vivo quantification of human pulmonary beta-adrenoceptor density using PET: Comparison with in vitro radioligand binding
30. Coexistence of b1- and b2-adrenoceptors in human heart and lung
31. Beta1- and beta2-adrenoceptors in the human heart: Properties, function and alterations in chronic heart failure
32. Parametric polar maps of regional myocardial beta-adrenoceptor density
33. Regional in vivo and in vitro characterization of autonomic innervation in cardiomyopathic human heart
34. Differences in beta-adrenoceptor binding in anterior and inferior myocardial wall microsomes of normal canine left ventricle
35. Pump dysfunction after myocardial infarction: Importance of location, extent and pattern of abnormal left ventricular segmental contraction