A high incidence of apolipoprotein E ε4 allele in middle-aged non-demented subjects with cerebral amyloid β protein deposits

Acta Neuropathologica

Volumn 97, Issue 1, 1999, Pages 82-84

  Arai, Tetsuaki ^a   Ikeda, Kenji ^a   Akiyama, Haruhiko ^a   Haga, Chie ^a   Usami, Mihoko ^a   Sahara, Naruhiko ^a   Iritani, Shuji ^b   Mori, Hiroshi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

Author keywords

Alzheimer's disease; Amyloid protein; Apolipoprotein E; Middle age

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; CLINICAL FEATURE; CONTROLLED STUDY; DEMENTIA; DISEASE COURSE; GENE FREQUENCY; GENOTYPE; HUMAN; PATHOLOGY; PRIORITY JOURNAL; RISK FACTOR;

ADULT; ALLELES; AMYLOID BETA-PROTEIN; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CEREBRAL CORTEX; GENE FREQUENCY; HIPPOCAMPUS; HUMANS; MIDDLE AGED; NEUROFIBRILLARY TANGLES; SENILE PLAQUES;

EID: 0033003126     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050958     Document Type: Article

References (14)

1. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
2. Braak H, Braak E, Bohl J, Reintjes R (1996) Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease. Neurosci Lett 210:87-90
3. Davis L, Wolska B, Hilbich C, Multhaup G, Martins R, Simms G, Beyreuther K, Masters CL (1988) A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology 38: 1688-1693
4. Gearing M, Schneider JA, Robins RS, Hollister RD, Mori H, Games D, Hyman BT, Mirra SS (1995) Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease. J Neuropathol Exp Neurol 54:833-841
5. Hixon JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res 31:545-548
6. Kametani F, Tanaka K, Ishii T, Ikeda S, Kennedy HE, Allsop D (1993) Secretory form of Alzheimer amyloid precursor protein 695 in human brain lacks β/A4 amyloid immunoreactivity. Biochem Biophys Res Commun 191:392-398
7. Lai F, William RS (1989) A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 46:849-853
8. Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372:92-94
9. Mackenzie IRA (1994) Senile plaques do not progressively accumulate with normal aging. Acta Neuropathol 87:520-525
10. Mann DMA, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci 89:169-179
11. Motte J, Williams RS (1989) Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain. Acta Neuropathol 77:535-546
12. Saunders AM, Strittmatter WJ, Schmechel D, St. George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD (1993) Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467-1472
13. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD (1993) Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 90:9649-9653
14. Sugihara S, Ogawa A, Nakazato Y, Yamaguchi H (1995) Cerebral β deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid. Acta Neuropathol 90: 135-141