The anti-fibrillogenic activity of tetracyclines on PrP 106-126: A 3D-QSAR study

Journal of Molecular Modeling

Volumn 14, Issue 10, 2008, Pages 987-994

  Cosentino, Ugo ^a   Pitea, Demetrio ^a   Moro, Giorgio ^a   Saracino, Gloria A A ^a   Caria, Pietro ^a   Varì, Rosaria M ^b   Colombo, Laura ^c   Forloni, Gianluigi ^c   Tagliavini, Fabrizio ^d   Salmona, Mario ^c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

3D QSAR analysis; Anti amyloidogenic activity; Prion protein; Tetracycline derivatives

Indexed keywords

4 EPICHLORTETRACYCLINE; 4 EPIOXYTETRACYCLINE; ANHYDROCHLORTETRACYCLINE; ANHYDROEPITETRACYCLINE; ANHYDROTETRACYCLINE; CHLORTETRACYCLINE; DEMECLOCYCLINE; DOXYCYCLINE; EPITETRACYCLINE; MECLOCYCLINE; METACYCLINE; MINOCYCLINE; OXYTETRACYCLINE; PRION 106-126 PROTEIN; PRION PROTEIN; ROLITETRACYCLINE; TETRACYCLINE; TETRACYCLINE DERIVATIVE;

ANTIFIBRILLOGENIC ACTIVITY; ARTICLE; BLOOD CLOTTING; DRUG ACTIVITY; DRUG STRUCTURE; GENETIC ALGORITHM; HEMOSTASIS; IN VITRO STUDY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; THREE DIMENSIONAL IMAGING;

NEUROFIBRILLARY TANGLES; PEPTIDE FRAGMENTS; PRIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINES;

EID: 50349102924     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-008-0348-2     Document Type: Article

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