NO-donors. Part 171: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8294-8300

  Konter, Joerg ^a   Möllmann, Ute ^b   Lehmann, Jochen ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Diazeniumdiolates; Hybrids; Ketoconazole; Nitric oxide; NO donors; NONOates

Indexed keywords

1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 4 (2 O ETHYLDIAZEN 1 IUM 1,2 DIOLATO)PIPERAZINE; 1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 4 (2 O METHOXYMETHYLDIAZEN 1 IUM 1,2 DIOLATO)PIPERAZINE; 1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 4 (2,2 DIMETHYL 3 OXOPROPYLNITRATE)PIPERAZINE; 1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL]PIPERAZINE; 1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL]PIPERAZINE 4 CARBOXYMETHYLNITRATE; 1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL]PIPERAZINE 4 ETHYLNITRATE; DIAZENIUMDIOLATE DERIVATIVE; KETOCONAZOLE; NITRIC OXIDE DONOR; O2 [1 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL]PIPERAZINE 4 CARBOXYMETHYL] 1 (PYRROLIDIN 1 YL)DIAZEN 1 IUM 1,2 DIOLATE; ORGANIC NITRATE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL STRAIN; HYBRID; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ASPERGILLUS; BASIDIOMYCOTA; CANDIDA; FUNGI; FUSARIUM; KETOCONAZOLE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE DONORS; PENICILLIUM CHRYSOGENUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50349101947     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.008     Document Type: Article

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