Probing conformational changes in the I-like domain and the cysteine-rich repeat of human β3 integrins following disulfide bond disruption by cysteine mutations. Identification of cysteine 598 involved in αIIbβ3 activation

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 38628-38635

  Chen, Ping ^a   Melchior, Chantal ^a   Brons, Nicolaas H C ^a   Schlegel, Nicole ^b   Caen, Jacques ^c   Kieffer, Nelly ^a,d  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c Institut de France   (France)

^d University Center   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; ANTIBODIES; COMPLEXATION; DIMERS; ELECTROPHORESIS; IONS; MUTAGENESIS;

ADHESION PLAQUES;

CONFORMATIONS;

ARGINYLGLYCYLASPARTYLSERINE; BETA3 INTEGRIN; CALCIUM ION; CHYMOTRYPSIN; COMPLEMENTARY DNA; CYSTEINE; DITHIOTHREITOL; EPITOPE; FIBRINOGEN; INTEGRIN RECEPTOR; METAL ION; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PAC 1; MUTANT PROTEIN; UNCLASSIFIED DRUG; DISULFIDE; FIBRINOGEN RECEPTOR; LEUKOCYTE ANTIGEN; LIGAND; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; EPITOPE MAPPING; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GLANZMANN DISEASE; LIGAND BINDING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BLOTTING, WESTERN; CELL ADHESION; CELL LINE; CHO CELLS; CRICETINAE; CYSTEINE; DIMERIZATION; DISULFIDES; DNA, COMPLEMENTARY; ENZYME ACTIVATION; EPITOPES; FIBRINOGEN; FLOW CYTOMETRY; HUMANS; INTEGRIN BETA3; LIGANDS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; PRECIPITIN TESTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0035914422     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105737200     Document Type: Article

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