Design and SAR of new substituted purines bearing aryl groups at N9 position as HIV-1 Tat-TAR interaction inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8178-8186

  Pang, Ruifang ^a   Zhang, Chunlei ^a   Yuan, Dekai ^a   Yang, Ming ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Antiviral; HIV 1 Tat TAR; Inhibitors; Substituted purines

Indexed keywords

HIV 1 TAT TAR INTERACTION INHIBITOR; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN INHIBITOR; PURINE DERIVATIVE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXICITY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS;

ANTI-HIV AGENTS; BINDING SITES; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PURINES; RNA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 50349086915     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.043     Document Type: Article

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