Morphology and morphometry of the reproductive organs in prepubertal and postpubertal male pigs exposed to di(2-ethylhexyl) phthalate before puberty: Precocious development of bulbourethral glands

Theriogenology

Volumn 70, Issue 6, 2008, Pages 984-991

  Ljungvall, Karl ^a   Veeramachaneni, D N Rao ^b   Hou, Mi ^c   Hultén, Fredrik ^d   Magnusson, Ulf ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Bulbourthral glands; Phthalates; Pig; Testes

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

AGE; ANIMAL; ARTICLE; BULBOURETHRAL GLAND; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; EVALUATION; GENITAL SYSTEM DISEASE; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; MALE; MALE GENITAL SYSTEM; PATHOLOGY; SEXUAL MATURATION; SWINE; TIME;

AGE FACTORS; ANIMALS; BULBOURETHRAL GLANDS; DIETHYLHEXYL PHTHALATE; GENITAL DISEASES, MALE; GENITALIA, MALE; MALE; SEXUAL MATURATION; SWINE; TIME FACTORS;

ANIMALIA; SUIDAE;

EID: 50249185257     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2008.05.061     Document Type: Article

References (25)

1. Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., et al. NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reproductive Toxicology 16 (2002) 529-653
2. Gray Jr. L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., and Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicological Sciences 58 (2000) 350-365
3. Parks L.G., Ostby J.S., Lambright C.R., Abbott B.D., Klinefelter G.R., Barlow N.J., et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicological Sciences 58 (2000) 339-349
4. Wilson V.S., Howdeshell K.L., Lambright C.S., Furr J., and Gray Jr. L.E. Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure. Toxicology Letters 170 (2007) 177-184
5. Akingbemi B.T., Youker R.T., Sottas C.M., Ge R., Katz E., Klinefelter G.R., et al. Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biology of Reproduction 65 (2001) 1252-1259
6. Kim H.S., Saito K., Ishizuka M., Kazusaka A., and Fujita S. Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats. Archives of Toxicology 77 (2003) 446-451
7. Akingbemi B.T., Ge R., Klinefelter G.R., Zirkin B.R., and Hardy M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 775-780
8. Sjoberg P., Bondesson U., Kjellen L., Lindquist N.G., Montin G., and Ploen L. Kinetics of di-(2-ethylhexyl) phthalate in immature and mature rats and effect on testis. Acta Pharmacologica et Toxicologica (Copenh) 56 (1985) 30-37
9. Ljungvall K., Karlsson P., Hulten F., Madej A., Norrgren L., Einarsson S., et al. Delayed effects on plasma concentration of testosterone and testicular morphology by intramuscular low-dose di(2-ethylhexyl)phthalate or oestradiol benzoate in the prepubertal boar. Theriogenology 64 (2005) 1170-1184
10. Ljungvall K., Spjuth L., Hulten F., Einarsson S., Rodriguez-Martinez H., Andersson K., et al. Early post-natal exposure to low dose oral di(2ethylhexyl) phthalate affects the peripheral LH-concentration in plasma, but does not affect mating behavior in the post-pubertal boar. Reproductive Toxicology 21 (2006) 160-166
11. Franca L.R., Silva Jr. V.A., Chiarini-Garcia H., Garcia S.K., and Debeljuk L. Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biology of Reproduction 63 (2000) 1629-1636
12. McCoard S.A., Lunstra D.D., Wise T.H., and Ford J.J. Specific staining of Sertoli cell nuclei and evaluation of Sertoli cell number and proliferative activity in Meishan and white composite boars during the neonatal period. Biology of Reproduction 64 (2001) 689-695
13. Payne A.H., Downing J.R., and Wong K.L. Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106 (1980) 1424-1429
14. Cooke P.S., Young P.F., and Cunha G.R. Androgen dependence of growth and epithelial morphogenesis in neonatal mouse bulbourethral glands. Endocrinology 121 (1987) 2153-2160
15. Cooke P.S., and Reicherts M.R. Anti-androgenic effects of Win 49,596 on development of the neonatal mouse bulbourethral gland in culture. Prostate 17 (1990) 145-154
16. Danzo B.J., Eller B.C., and Hendry III W.J. Identification of cytoplasmic estrogen receptors in the accessory sex organs of the rabbit and their comparison to the cytoplasmic estrogen receptor in the epididymis. Molecular and Cellular Endocrinology 33 (1983) 197-209
17. Deschamps J.C., Ott R.S., McEntee K., Heath E.H., Heinrichs R.R., Shanks R.D., et al. Effects of zeranol on reproduction in beef bulls: scrotal circumference, serving ability, semen characteristics, and pathologic changes of the reproductive organs. American Journal of Veterinary Research 48 (1987) 137-147
18. Parrott R.F., and Booth W.D. Behavioural and morphological effects of 5 alpha-dihydrotestosterone and oestradiol 17 beta in the prepubertally castrated boar. Journal of Reproduction and Fertility 71 (1984) 453-461
19. Wilson V.S., Blystone C.R., Hotchkiss A.K., Rider C.V., and Gray Jr. L.E. Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development. International Journal of Andrology 31 2 (2008) 178-187
20. Higuchi T.T., Palmer J.S., Gray Jr. L.E., and Veeramachaneni D.N.R. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicological Sciences 72 (2003) 301-313
21. Gaido K.W., Hensley J.B., Liu D., Wallace D.G., Borghoff S., Johnson K.J., et al. Fetal mouse phthalate exposure shows that gonocyte multinucleation is not associated with decreased testicular testosterone. Toxicological Sciences 97 (2007) 491-503
22. Larsson K., Einarsson S., and Nicander L. Influence of thawing diluents on vitality, acrosome morphology, ultrastructure and enzyme release of deep frozen boar spermatozoa. Acta Veterinaria Scandinavica 17 (1976) 83-100
23. Badia E., Pinart E., Briz M., Pastor L.M., Sancho S., Garcia-Gil N., et al. Lectin histochemistry of the boar bulbourethral glands. European Journal of Histochemistry 49 (2005) 131-138
24. Awal M.A., Kurohmaru M., Andriana B.B., Kanai Y., and Hayashi Y. Mono-(2-ethylhexyl) phthalate (MEHP) induces testicular alterations in male guinea pigs at prepubertal stage. Tissue Cell 37 (2005) 167-175
25. Dostal L.A., Chapin R.E., Stefanski S.A., Harris M.W., and Schwetz B.A. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Toxicology and applied pharmacology 95 (1988) 104-121