Morphological Characterization and Subtyping of Silent Somatotroph Adenomas

Pituitary

Volumn 1, Issue 3-4, 1999, Pages 233-241

  Naritaka, Heiji ^a,c   Kameya, Toru ^a,d   Sato, Yuichi ^a   Furuhata, Shigeru ^a   Otani, Mitsuhiro ^b   Kawase, Takeshi ^b  

^a KITASATO UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c TOKYO DENTAL COLLEGE   (Japan)

^d KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

GH mRNA; In situ hybridization; Silent somatotroph adenoma; Subtype

Indexed keywords

ADENOHYPOPHYSIS HORMONE; DIAGNOSTIC AGENT; HUMAN GROWTH HORMONE; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN P53; PROTIRELIN; RNA;

ACROMEGALY; ADENOMA; ADULT; AGED; ARTICLE; BIOSYNTHESIS; CHILD; FEMALE; GENETICS; HUMAN; HYPOPHYSIS TUMOR; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION;

ACROMEGALY; ADENOMA; ADULT; AGED; CHILD; FEMALE; HUMAN GROWTH HORMONE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KI-67 ANTIGEN; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; PITUITARY HORMONES, ANTERIOR; PITUITARY NEOPLASMS; RNA, MESSENGER; RNA, NEOPLASM; THYROTROPIN-RELEASING HORMONE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033123113     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1009942122673     Document Type: Article

References (25)

1. Kovacs K, Horvath E, Bayley TA, Hassaram ST, Ezrin C. Silent corticotroph cell adenoma with lysosomal accumulation and crinophagy. Am J Med 1978;64:492-499.
2. Holck S, Wewer UM, Albrechtsen R. Heterogeneity of secretory granules of silent pituitary adenomas. Mod Pathol 1988;3:212-215.
3. Heshmati HM, Turpin G, Kujas M, Lam X, Van Effenterre R, Racadot J, de Gennes J.L. The immunocytochemical heterogeneity of silent pituitary adenomas. Acta Neuropathol 1988;118:533-537.
4. Horvath E, Kovacs K, Killinger DW, Smyth HS, Platts ME, Singer W. Silent corticotropic adenomas of the human pituitary gland. A histologic, immunocytologic, and ultrastructural study. Am J Pathol 1980;98:617-638.
5. Hassoun J, Charpin C, Jaquet P, Lissitzly J C, Grisoli F, Toga M. Corticolipotropin immunoreactivity in silent chromophobe adenomas. A light and electron microscopic study. Arch Pathol Lab Med 1982;106:25-30.
6. Lloyd RV, Fields K, Jin L, Horvath E, Kovacs K. Analysis of endocrine active and clinically silent corticotropic adenomas by in situ hybridization. Am J Pathol 1990;137:479-488.
7. Kovacs K, Lloyd R, Horvath E, Asa SL, Stefaneanu L, Killinger DW, Smyth HS. Silent somatotroph adenomas of the human pituitary. Am J Pathol 1989;134:345-353.
8. Tourniaire J, Trouillas J, Chalendar D, Bonneton-Emptoz A, Goutelle A, Girod C. Somatotropic adenoma manifested by galactorrhea without acromegaly. J Clin Endocrinol Metab 1985;60:513-516.
9. Klibanski A, Zervas NT, Kovacs K, Ridgway EC. Clinically silent hypersecretion of growth hormone in patients with pituitary tumors. J Neurosurg 1987;66:806-811.
10. Horvath E, Kovacs K, Singer W, Ezrin C, Kerenyi NA. Acidphil stem cell adenoma of the human pituitary. Arch Pathol Lab Med 1977;101:594-599.
11. Moses AC, Molitch ME, Sawin CT, Jackson IMD, Biller BJ, Furlanetto R, Reichlin S. Bromocriptine therapy in acromegaly: Use in patients resistant to conventional therapy and effect on serum levels of somatomedin C. J Clin Endocrinol Metab 1981;53:752-758.
12. Pagesy P, Li JY, Rentier-Delrue F, Delalande O, Le Bouc Y, Kujas M, Joubert (Bression) D, Martial JA, Peillon F. Growth hormone and somatostatin gene in pituitary adenomas with active acromegaly and minimal plasma growth hormone elevation. Acta Endocrinol 1990;122:745-752.
13. Pagesy P, Li JY, Kujas M, Peillon F, Delalande O, Visot A, Derome P. Apparently silent somatotroph adenomas. Path Res Pract 1991;187:950-956.
14. Kameya T, Tsumuraya M, Adachi I, Abe K, Ichikizaki K, Toya S, Demura R. Ultrastructure, immunohistochemistry and hormone release of pituitary adenomas in relation to prolactin production. Virchows Arch [Pathol Anat] 1981; 387:31-46.
15. Jiang SX, Kameya T, Sato. Y, Yanase N, Yoshimura H, Kodama T. Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation. Am J Pathol 1996;148:837-846.
16. Furuhata S, Kameya T, Nemoto N, Miyazawa S, Otani M, Toya S. Pitfalls in the double labelling immunoelectron microscopy using one face of the grid. J Electron Microsc 1992;41:120-122.
17. Naritaka H, Kameya T, Furuhata S, Otani M, Toya S. An atypical acidphil cell line tumor showing focal differentiation towards both growth hormone and prolactin cells. Endocr Pathol 1995;3:239-246.
18. Nagaya T, Seo H, Kuwayama A, Sakurai T, Tsukamoto N, Nakane T, Sugita K, Matsui N. Pro-opiomelanocortin gene expression in silent corticotroph-cell adenoma and Cushing's disease. J Neurosurg 1990;72:262-267.
19. Sakurai T, Seo H, Yamamoto N, Nagaya T, Nakane T, Kuwayama A, Kageyama N, Matsui N. Detection of mRNA of prolactin and ACTH in clinically nonfunctioning pituitary adenomas. J Neurosurg 1988;69:653-659.
20. Nur I, Reinhartz A, Hyman HC. Chemiprobe, a non-radioactive system for labelling nucleic acid - Principles and application. Ann Biol Clin 1989;47:601-606.
21. Lloyd RV, Cano M, Chandler WF, Barkan AL, Horvath E, Kovacs K. Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization. Am J Pathol 1989;134:605-613.
22. Saeger W, Uhlig H, Baz E. In situ hybridization for different mRNA in GH-secreting and in inactive pituitary adenomas. Path Res Pract 1991;187:559-563.
23. Kovacs K, Horvath E. Tumors of the pituitary gland. Atlas of Tumor Pathology, 2nd series. Washington, DC: Fascicle 21, Armed Forces Institute of Pathology, 1986.
24. Yamada S, Sano T, Stefaneanu L, Kovacs K, Aiba T, Sawano S, Shishiba Y. Endocrine and morphological study of a clinically silent somatotroph adenoma of the human pituitary. J Clin Endocrinol Metab 1993;76:352-356.
25. Furuhata S, Kameya T, Otani M, Toya S. Silent mixed growth hormone cell-prolactin cell pituitary adenoma. Endocr Pathol 1991;2:230-234.