Cytochemical and molecular biological aspects of the pituitary and pituitary adenomas - Cell differentiation and transcription factors

Progress in Histochemistry and Cytochemistry

Volumn 36, Issue 4, 2001, Pages 261-300

  Sanno, Naoko ^a   Tahara, Shigeyuki ^a   Kurotani, Reiko ^a   Matsuno, Akira ^a   Teramoto, Akira ^a   Osamura, Robert Yoshiyuki ^a  

^a NONE

Author keywords

Classsification of pituitary adenomas; Functional differentiation; Gene transcripts; Hypothalamic regulation; Immunocytochemistry; In situ hybrixdization; Laser captiure microdissection; Nuclear receptors; Pituitary adenomas

Indexed keywords

CELL RECEPTOR; HYPOPHYSIS HORMONE; HYPOTHALAMUS HORMONE; TRANSCRIPTION FACTOR;

ADENOHYPOPHYSIS; ADENOMA; BIOSYNTHESIS; CELL DIFFERENTIATION; CLASSIFICATION; GENETIC TRANSCRIPTION; GROWTH, DEVELOPMENT AND AGING; HUMAN; HYPOPHYSIS TUMOR; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REVIEW; SECRETION;

ADENOMA; CELL DIFFERENTIATION; HUMANS; HYPOTHALAMIC HORMONES; IMMUNOHISTOCHEMISTRY; PITUITARY GLAND, ANTERIOR; PITUITARY HORMONES; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035753727     PISSN: 00796336     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0079-6336(00)80003-0     Document Type: Article

References (159)

1. ACAMPORA, D., MAZEN,S., FRANCESCA, T., AVANTAGGIATO,V., TREMBLAY,J.J., LAZZARO, D., CARLO, A., MARIANO, A., MACCHIA, P. E., CORTE, G., MACCHIA, V, DROUIN,J., BRULET, P., SIMEONE, A.: Transient dwarfism and hypogonadism in mice lacking Otxl revel prepubescent stage specific control of pituitary levels of GH, FSH and LH. - Develop. 125, 1229-1239 (1998).
2. ACAMPORA, D., POSTIGLIONE, M. P., AVANTAGGIATO, V., DI BONITO, M., SIMEONE, A.: The role of Otx and Otp genes in brain development. - Intern. J. developm. Biol. 44, 669-77 (2000).
3. AGUADO, F., MAJO, G., RUIZ-MONTASELL, B., CANALS, J. M., CASANOVA, A., MARSAL, J., BLASI, J.: Expression of synaptosomal-associated protein SNAP-25 in endocrine anterior pituitary cells. - Eur. J. Cell Biol. 69, 351-359 (1996)
4. ALEXANDER, J. M., BILLER, B. M. K, BIKKAL, H., ZARVAS, N. T., ARNOLD, A., KLIBANSKI, A.: Clinically non-functioning pituitary tumors are monoclonal in origin. - J. clin. Invest. 86, 336-340 (1990).
5. ALLENBY, G., BOCQUEL,M. T., SAUNDERS, M., KAZMER, S., SPECK, J., ROSENBERGER, M., LOVEY, A., KASTNER, P., GRIPPO, J. F., CHAMBON, P., LEVIN, A.A.: Retinoic acid receptors and retinoid X receptors. Interactions with endogenous retinoic acids. - Proc natl. Acad. Sci. USA 90, 30-34 (1993).
6. ASA, S. L., BAMBERGER, A. M., CAO, B., WONG, M., PARKER, K. L., EZZAT, S.: The transcription activator steroidgenic factor-1 is preferentially expressed in the human pituitary gonadotroph.-J. clin Endocrin. Metab. 81, 2165-2170 (1996).
7. ASA, S. L., EZZAT, S.: Molecular determinants of pituitary cytodifferentiation. - Pituitary 1, 159-168 (1999).
8. ASA, S. L., PU, L. A., LEW, A. M.: Cell type-specific expression of the pituitary transcription activator Pit-1 in the human pituitary and pituitary adenomas. - J. clin Endocrin. Metab. 77, 1275-1280 (1993).
9. BAGASRA, O., HAUPTMAN, S. P., LISCHNER, H. W., SACHS, M., POMERANTZ, R. J.: The detection by in-situ polymerase chain reaction of provirus in mononuclear cells of certain individuals infected with HIV-1. - New Engl. J. Med. 326, 1385-1391 (1992).
10. BALDINI, G., HOHL, T., LIN, H. Y., LODISH, H. F.: Cloning of Rab3 isotype predominantly expressed in adipocytes. - Proc. natl. Acad. Sci. USA 89, 5049-5052 (1992).
11. BATTIFORA, H., ALSABEH, R., JENKINS, K. A., GOWN, A.: Epitope retrieval (unmasking) in immunohistochemistry. - Adv. Pathol. Lab. Med. 8, 101-118 (1995).
12. BAUMEISTER, H., WEGNER, M., RICHTER, D., MEYERHOF, W.: Dual regulation of somatostatin receptor subtype 1 gene expression by pit-1 in anterior pituitary GH3 cells. - Mol Endocrinol. 14, 255-71 (2000).
13. BAZ, E., SAEGER, W., UHLIG, H. et al.: HGH, PRL and αHCG/αLH gene expression in clinically inactive pituitary adenomas detected by in situ hybridization. - Virchows Arch. A Pathol. Anat. 418, 405-410 (1991).
14. BERRODIN, T. J., MARKS, M. S., OZATO, K., LINNEY, E., LAZAR, M. A.: Heteredimierization among thyroid hormone receptor, retinoic acid receptor, retinoid X receotir, COUP transcription factor and an endogenous liver protein. - Mol. Endocrinol. 6, 1469-1487 (1992).
15. BLOOMQUIST, B. T., EIPPER, B. A., MAINS, R. E.: Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. - Mol Endocrinol. 5, 2014-2024 (1991).
16. BOBROW, M. N., HARRIS, T. D., SHAUGHNESSY, K. J., LITT, G. J.: Catalyzed reporter deposition, a novel method of signal amplification: Application to immunoassays. - J. Immunol. Meth. 125, 279-285 (1989).
17. BODNER, M., CASTRILLO, J. L., THEILL, L. E., DEERINCK, T., ELLISMAN, M., KARIN, M.: The pitutiary-specific transcription factor GHF-1 is a homeobox-containing protein. - Cell 55, 505-518 (1988).
18. BONNER, R. F., EMMERT-BICK, M., COLE, K., ROHIDA, T., CHUAQUI, R., GOLDSTEIN, S., LIOTTA, L. A.: Laser capture microdissection: molecular analysis of tissue. - Science 278, 1481-83 (1997).
19. BOURNE, H. R.: Do GTPases direct membrane traffic in secretion? 1997:Cell 53, 669-671 (1988).
20. CAMPER, S. A., SAUNDERS, T. L., KATZ, R. W., REEVES, R. H.: The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation. - Genomic 8, 586-590 (1990).
21. CASTRILLO, J. L., THEILL, L. E., KARIN, M.: Function of the homeodomain protein GHF 1 in pituitary cell proliferation. - Science 253, 197-199 (1991).
22. CATTORETTI, G., BECKER, M. H. G., KEY, G. et al: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. - J. Pathol. 168, 357-363 (1992).
23. CHAIDARUN, S. S., KLIBANSKI, A., ALEXANDER, J. M.: Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas. - clin. Endocrinol. Metabol. 82, 1058-65 (1997).
24. CHANCE, R. E., ELLIS, R. M., BROMER, W. W.: Porcine proinsulin: characterization and amino acid sequence. - Science 161, 165-167 (1968).
25. CHRETIEN, M., LIE, C. H.: Isolation, purification, and characterization of β-lipotropic hormone from sheep pituitary glands. - Can. J. Biochem. 45, 1164-1174(1967).
26. CRAXTON, M., GOEDERT, M.: Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain. - FEBS Lett 361, 196-200 (1995).
27. DAIKOKU, S., CHIKAMORI, M., AACHI, T., MAKI, Y.: Effect of the basal dienephalon on the development of Rathke's pouch in rats: a study in combined organ cultures. - Dev. Biol. 90, 198-202 (1982).
28. DASEN, J. S., ROSENFELD, M. G.: Signaling mechanisms in pituitary morphogenesis and cell fate determination. - Curr. Opin. in Cell Biol. 11, 669-677 (1999).
29. DAVIS, K. D., BERRODIN, T. J., STELMACH, J. E., WINKLER, J. D., LAZAR, M. A.: Endogenous retinoid X receptors can function as hormone receptors in pituitary cells. - Mol. Cell Biol. 14, 7105-7110 (1994).
30. DOLLE, P., CASTRILLO, J. L., THEILL, L. E., DEERINCK, T., ELLISMAN, M., KARIN, M.: Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. - Cell 60, 809-820 (1990).
31. EGGER, D., TROXLER, M., BIENZ, K.: Light and electron microscopic in situ hybridization: nonradioactive labeling and detection, double hybridization , and combined hybridization-immunocytochemistry. - J Histochem Cytochem. 42, 815-822 (1994).
32. EMMERT-BUCK, M. R., BONNER, R. F., SMITH, P. D., CHUAQUI, R. F., ZHUANG, Z., GOLDSTEN, S. R., WEISS, RA, LIOTTA, L. A.: Laser capture microdissection. - Science 274, 998-1001 (1996).
33. EVANS, R. M.: The steroid and thyroid hormone receptor superfamily. - Science 240, 889-895 (1988).
34. EZZART, S., ASA, S. L., STEFANEANU, L., WHITTOM, R., SMYTH, H. S., HORVATH, E., KOVACS, K., FROHMAN, L. A.: Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing-hormone-producing bronchial carcinoid. - J. clin. Endocrinol. Metab. 78, 555-560 (1994).
35. FISCHER VON MOLLARD, G., MIGNERY, G., BAUMERT, M., PERIN, M. S, HANSON, T. J., BURGER, P. M., JAHN, R., SUDHOF, T. C.: Rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. - Proc. natl. Acad. Sci. USA 87, 1988-1992 (1990).
36. FISCHER VON MOLLARD, G., STAHL, B., LI, C., KHOKHLATCHEV, A., SUDHOF, T. C., JAHN, R.: Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. - J. biol. Chem. 269, 10971-10974 (1994a).
37. FISCHER VON MOLLARD, G., STAHL, B., LI, C., SUDHOF, T. C., JAHN, R.: Rab3 proteins in regulated exocytosis. - Trends Biochem. Sci. 19, 164-168 (1994b).
38. FISCHER VON MOLLARD, G., SUDHOF, T. C., JAHN, R.: A small GTP-binding protein dissociates from synaptic vesicles during exocytosis. - Nature 349, 79-81 (1991).
39. FRIEND, K. E., CHIOUR, Y. K., LAWS, E. R.: Pit-1 messenger ribonucleid acid is differentially expressed in human pituitary adenomas. - J. clin Endocrinol. Metab. 77, 1281-1286 (1993).
40. GAGE, P. J., BRINKMEIER, M. L., SCHARLETT, L. M., KNAPP, L. T., CAMPER, S. A., MAHON, K. A.: The ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of rpx transcription and initiation of lineage-specific cell proliferation. - Mol. Endocrinol. 10, 1570-1581 (1996).
41. GAGE, P. J., SUH, H., CAMPER, S. A.: Dosage requirement of Pitx2 for development of multiple organs. - Development 126, 4643-51 (1999).
42. GEPPERT, M., BOLSHAKOV, V. Y., SIEGELBAUM, S. A., TAKEI, K., CAMILLI, P. D., HAMMER, R. E., SUDHOF, T. C.: The role of Rab3A in neurotransmitter release. - Nature 369, 493-497 (1994).
43. HAMADA, K., GLEASON, S. L., LEVI, B.-Z., HIRSHFIELD, S., APPELLA, E., OZATO, K.: H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc Natl Acad Sci USA 86, 8289-8293 (1989).]
44. HAMMER, G. D., INGRAHAM, H. A.: Steroidogenic factor-1: its role in endocrine organ development and differentiation. - Front Neuroendocrinol. 20, 199-223 (1999).
45. HASHIMOTO, K., KOVA, M., KOUHARA, H., ARITA, N., HAYAKAWA, T, KISHIMOTO, T., SATO, B.: Expression patterns of messenger ribonucleic acids encoding prohormone convertases (PC2 and PC3) in human pituitary adenomas. - Clin. Endocrinol. 41, 185-191 (1994).
46. HAUGAN, B. R., GORDON, D. F., NELSON, A. R., WOOD, W. M., RIDGWAY, R. C.: The combination of Pit-1 and Pit-1T have a synergistic stimulatory effect on the thyrotropin α-subunit promoter but not the growth hormone or prolactin promoters. - Mol. Endocrinol. 8, 1574-1582 (1994).
47. HERMESZ, E., MACKEM, S., MAHON, K. A.: Rpx: a novel anterior-restiricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse emblyo. - Development 122, 41-52 (1996).
48. HEYMAN, R. A., BRONDYK, W. H., SENTER, R. A., KUIZON, L., MACARA, I. G.: Evidence for the involvement of Rab3A in Ca2+ -dependent exocytosis from adrenal chromaffin cells. - J. biol. Chem. 269, 10229-10234 (1994).
49. HOLZ, R. W., SENTER, R. A., UHLER, M. D.: Investigation by transient transfection of the effects on regulated exocytosis of Rab3a. - Meth. Enzymol. 257, 221-231 (1995).
50. HONDA, S., MOROHASHI, K., NOMURA, M., TAKEYA, M., KITAJIMA, M., OMURA, T: Ad4BP regulating steroidogenic P-450 genes is a member of steroid hormone receptor superfamily. - J. biol. Chem. 268, 7479-7502 (1993).
51. HORVATH, E., KOVACS, K.: Pathology of the pituitary gland. - In: EZRIN, C., HORVATH, E., KAUFMAN, B., KOVACS, K., WEISS, M. H, eds., Pituitary Diseases. - CRC Press, Boca Roton FL, pp. 1-83 (1980).
52. -: Ultrastructural diagnosis of human pituitary adenomas. - Microsc. Res. Tech. 20, 107-135 (1992).
53. HOSODA, H., KOJIMA, M., MATSUO, H., KANAGAWA, K.: Purification and characterization of rat des-Glu14-ghrelin, a second endogenous ligand for growth hormone secretagogue receptor. - J. biol. Chem. 275, 21 995-22 000 (2000).
54. -: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. - Bio. chem. biophys. Res. Comm. 279, 909-913 (2000).
55. HSU, S. M., RAINE, E., FANGER, H.: Use of avidin-biotine-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. -J. Histochem. Cytochem. 29, 577-580 (1981).
56. INGRAHAM, H. A., CHEN, R. P., MANGALAM, H. J., ELSHOLTZ, H. P., FLYNN, S. E., LIN, C. R., SIMMONS, D. M., SWANSON, L., ROSENFELD, M. G.: A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. - Cell 55, 519-529 (1988).
57. INGRAHAM, H.A., LALA, D.S., IKEDA, Y., LUO, X., SHEN, W. H., NACHTIGAL, M. W., ABBUD, R., NILSON, J. H., PARKER K. L.: The nuclear receptor steroidogenic factor I acts at multiple levels of the reproductive axis. - Genes Dev. 8, 2302-2312 (1994).
58. INOUE, K., HATTORI, M., SAKAI, T., INUKAI, S., FUJIMOTO, N., ITO, A.: Establishment of a series of pituitary clonal cell lines differing in morphology, hormone secretion, and response to estrogen. - Endocrinology 126, 2313-2320 (1990).
59. ITOH, J., SANNO, N., MASTUNO, A., ITOH, Y., TAKEKOSHI, S., OSAMURA, R. Y., WATANABE, K.: An application of confocal laser scanning microscopy (CLSM) to visualize in situ hybridization (ISH) signals of prolactin (PRL) mRNA in normal and estrogen-treated rat pituitary glands. - Cell Vision 2, 266 (1995).
60. JACOBSON, A. G., MIYAMOTO, D. M., MAI, S.-H.: Rathke's pouch morphogenesis in the chick embryo. -J. exp. Zool. 207, 351-366 (1979).
61. JIN, L., LLOYD, R. V.: Comparison of mRNA expression detected by in situ PCR and in situ hybridization in endocrine cells. - Cell Vision 2, 314-321 (1995).
62. JIN, L., SCHEITHAUER, B. W., YOUNG, W. F. JR., DAVIS, D. H., KLEE, G. G., LLOYD, R. V.: Pancreastatin secretion by pituitary adenomas and regulation of chromogranin B mRNA expression. - Am. J. Pathol. 148, 2057-2066 (1996).
63. JOHANNES, L., LLEDO, P. M., ROA, M., VINCENT, J. D, HENRY, J. P., DARCHEN, E: The GTP ase Rab 3b negatively controls calcium-dependent exocytosis in neuroendocrine cells. - EMBO J. 13, 2029-2037 (1994).
64. KELLER, H., GIVEL, F., PERROUD, M., WAHLI, W.: Signal cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. - Mol. Endocrinol. 9, 794-804 (1995).
65. KIM, K., ARAI, K., SANNO, N., OSAMURA, R. Y., TERAMOTO, A., SHIBASAKI, T.: Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA in human pituitary adenomas, (in press 2001).
66. KIM, K., ARAI, K., SANNO, N., TERAMOTO, A., SHIBASAKI, T.: The expression of thyrotropin-releasing hormone receptor 1 messenger ribonucleic acid in human pituitary adenomas. - Clin. Endocrinol. 54, 309-316 (2001).
67. KLIEWER, S.A., UMESONO, K., HEYMAN, R. A., MANGELSDORF, D. J., DYCK, J. A., EVANS, R. M.: Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. - Proc. natl. Acad. Sci. USA 89, 1448-52 (1992).
68. KORBONITS, M., BUSTIN, S.A., KOJIMA, M., JORDAN, S., ADAMS, E. F., LOWE, D. G., KANGAWA, K., GROSSMAN, A. B.: The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. -J. clin. Endocrinol. Metab. 86, 881-887 (2001).
69. KOJIMA, M., HOSODA, H., DATE, Y., NAKAZATO, M., MATSUO, H., KANAGAWA, K.: Ghrelin is a growth- hormone-releasing acylated peptide from stomach. - Nature 402, 656-660 (1999).
70. KONZAK K.E., MOORE, D.D.: Functional isoforms of Pit-1 generated by alternative messenger RNA splicing. - Mol Endocrinol. 6, 241-247 (1992).
71. KOVACS, K., SCHEITHAUER, B. W., HORVATH, E., LLOYD, R. V.: The World Health Organization classification of adenohypophysial neoplasms. A proposed five-tier scheme. - Cancer. 78, 502-10 (1996).
72. KUROTANI, R., TAHARA, S., SANNO, N., TERAMOTO, A., MELLON, P. L., INOUE, K., YOSHIMURA, S., OSAMURA, R. Y: Expression of Ptxl in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. - Cell Tissue Res. 298, 55-61 (1999).
73. LAMONERIE, T., TREMBLAY, J. J., LANCTOT, C., THERRIEN, M., GAUTHIER, Y., DROUIN, J.: Ptxl, a biocoid-related homeo box transcription factor involved in transcription of the proopiomelanocortine gene. - Genes Dev. 10, 1284-1295 (1996).
74. LEID, M., KASTNER, P., LYONS, R., NAKSHATRI, H., SAUNDERS, M., ZACHAREWSKI, T., CHEN, J. Y., STAUB, A., GARNIER, J. M., MADER, S.: Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. - Cell 68, 377-95 (1992).
75. LEVIN, A. A., STURZENBECKER, L. J., KAZMER, S., BOSAKOWSKI, T., HUSELTON, C., ALLENBY, G., SPECK, J., KRATZEISEN, C., ROSENBERGER, M., LOVEY, A.: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha. - Nature 355, 359-61 (1992).
76. LI, S., CRENSHAW, E. B., RAWSON, E. J., SIMMONS, D. M., SWANSON, L. W., ROSENFELD, M. G.: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature 347, 528-533 (1990).
77. LIN, C., LIN, S. C., CHANG, C. P., ROSENFELD, M. G.: Pit-1-dependent expression of the receptor for growth hormone-releasing factor mediates pituitary cell growth. - Nature 360, 765-768 (1992).
78. LIN, C. R., KOUSSI, C., O'CONNELL, S., BRIATA, P., SZETO, D., LIU, F., IZPISUA-BELMONT, J. C., ROSENFELD, M. G.: Ptx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. - Nature 401, 279-282 (1999).
79. LLOYD, R. V., FIELD, K., JIN, L. et al.: Analysis of endocrine active and clinically silent corticotropic adenomas by in situ hybridization. - Am. J. Pathol. 137, 479-488 (1990).
80. LLOYD, R. V., JIN, L., CHANDLER, W. R: In situ hybridization studies in human pituitaries. - In: Pituitary Adenomas, pp.47-48 Landolt, A. M., Vance, M. L., Reilly, P. L., eds., Churchill Livingstone, New York 1996.
81. LLOYD, R. V., JIN, L., QIAN, X., SCHEITHAUER, B. W., YOUNG, W. F. JR., DAVIS, D. H.: Analysis of the chromogranin A post-translational product pancreastatin and the prohormone convertases PC2 and PC3 in normal and neoplastic human pituitaries. - Am. J. Pathol. 146, 1188-1198 (1995).
82. LLOYD, R. V., WILSON, B. S.: Specific endocrine tissue marker defined by a monoclonal antibody. - Science 222, 628-630 (1983).
83. LONG, A. A., KOMMINOTH, P., LEE, E., WOLFE, H. J.: Comparison of indirect and direct in-situ polymerase chain reaction in cell preparations and tissue sections. Detection of viral DNA, gene rearrangement and chromosomal translocations. - Histochemistry 99, 151-162 (1993).
84. LOPEZ, M. B., GAYLINN, B. D., THORNER, M. O., STOLER, M. H.: Growth hormone-releasing hormone receptor mRNA in acromegalic pituitary tumors. - Am. J. Pathol. 150, 1885-1891 (1997).
85. LUO, X., IKEDA, Y., LALA, D., RICE, D., WONG, M., PARKER, K. L.: Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. -J. Steroid biochem. mol. Biol. 69, 13-18 (1999).
86. MANGALAM, H. J., ALBERT, V. R, INGRAHAM H. A., KAPILOFF, M., WILSON, L., NELSON, C., ELSHOLTZ, H., ROSENFELD, M. G.: A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. - Gen Dev. 3, 946-58 (1989).
87. MARQUEZE, B., BOUDIER, J. A., MIZUTA, M., INAGAKI, N., SEINO, S., SEAGAR, M.: Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat. -J. Neurosci. 15(7 Pt 1), 4906-17 (1995).
88. MATSUNO, A., OHSUGI, Y., UTSUNOMIYA, H., TAKEKOSHI, S., SANNO, N. et al.: Changes in the ultrastructural distribution of prolactin and growth hormone mRNAs in pituitary cells of female rat after estrogen and bromocriptine treatment, studied using in situ hybridization with biotinylated oligonucleotide probes. - Histochem. Cell Biol. 104, 37-45 (1995).
89. MATSUNO, A., KATAKAMI, H., SANNO, N., OGINO, Y., OSAMURA, R. Y., MATSUKURA, S., SHIMIZU, N., NAGASHIMA, T.: Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: A model case for autocrine and paracrine regulation of GH secretion by GHRH. -J. clin Endocrin. Metab. 84, 3241-3247 (1999).
90. MATSUNO, A., SANNO, N., TAHARA, S., TERAMOTO, A., OSAMURA, R. Y., WADA, H., MURAKAMI, M., TANAKA, H., NAGASHIMA, T.: Silent somatotroph adenoma, detected by catalyzed signal amplification and non-radioisotopic in situ hybridization. - Endocrin. J. 46 (Suppl) S81-84 (1999).
91. MATSUNO, A., TERAMOTO, A., TAKEKOSHI, S., SANNO, N., OSAMURA, R. Y., KIRINO, T.: Expression of plurihormonal mRNAs in somatotroph adenomas detected using a non-isotopic in situ hybridization method-comparison with lactotroph adenomas. - Hum. Pathol. 26, 272-279 (1995).
92. MILLER, K., AULD, J., JESSUP, E. et al.: Antigen unmasking in formalin-fixed routinely processed paraffin wax-embedded sections by pressure cooking: A comparison with microwave oven heating and traditional methods. - Adv. Anat. Pathol. 2, 60-64 (1994).
93. MIZUTA, M., INAGAKI, N., NEMOTO, Y., MATSUKURA, S., TAKAHASHI, M., SEINO, S.: Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. - J. biol. Chem. 269, 11675-11678 (1994).
94. MOMOSE, H., MEHTA, P., BATTIFORA, H.: Antigen retrieval by microwave irradiation in lead thiocyanate. A comparison with protease digestion retrieval. - Appl. Immunohistochem. 1, 77-82 (1993).
95. MOROHASHI, K., HONDA, S., INOMATA, Y., HANDA, H., OMURA, T.: A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. - J. biol. Chem. 267, 17913-17919 (1992).
96. MOROHASHI, K., IIDA, H., NOMURA, M., HATANO, O., HONDA, S., TSUKIYAMA, T., NIWA, O., HARA, T., TAKAKUSU, A., SHIBATA, Y.: Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. - Mol. Endocrinol. 8, 643-53 (1994).
97. NAKAMURA, Y, USUI, T., MIZUTA, H., MURABE, H., MURO, S., SUDA, M., TANAKA, K., TANAKA, I., SHIMATSU, A., NAKAO, K.: Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans. -J. clin. Endocrinol. Metab. 84, 1414-1419 (1999).
98. NAYA, F. J., STELLRECHT, C. M., TSAI, M. J.: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. - Gene Dev. 9, 1009-1019 (1995).
99. NORTON, A. J., JORDAN, S., YEOMANS, P.: Brief, high-temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues. - J. Pathol. 773, 371-379 (1994).
100. Nuovo, G. J., BECKER, J., SIMSIR, A., MARGIOTTA, M., KHALIFE, G., SHEVCHEUK, M.: HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in-situ hybridization. - Am. J. Pathol. 144, 1142-1148 (1994).
101. Nuovo, G. J., GORGONE, G. A., MACCONNEL, P., MARGIOTTA, M., GOREVIC, P. D.: In situ localization of PCR-amplified human and viral cDNA. - PCR Meth. appl 2, 117-223 (1992).
102. OHAGI, S., LAMENDOLA, J., LEBEAU, M. M., ESPINOSA, R. III, TAKEDA, J., SMEEKENS, S. P.: Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues. - Proc. Natl. Acad. Sci. USA 89, 4977-4981 (1992).
103. OKA, H., JIN, L., SCHEITHAUER, B. W., SANNO, N., FUJII, K., KAMEYA, T., PLUMMER, T. B., LLOYD, R. V.: Growth hormone-releasing hormone receptor (GHRH-R) mRNA expression in human pituitary adenomas: A study by catalyzed reporter deposiotion-in situ hybridization (CARDISH). - Endocr. Pathol. 10, 27-36 (1999).
104. OSAMURA, R. Y. ODA, K., UTSUNOMIYA, H., INADA, K., UMEMURA, S., SHIBUYA, M., KATAKAMI, H., Voss, J. W., MAYO, K. E., ROSENFELD, M. G.: Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions. - Endocrin. J. 40, 133-139 (1993).
105. OSAMURA, R. Y., SANNO, N., TERAMOTO, A.: Clinical and cytofunctional classification of pituitary adenomas: Proposal of a new classification. - Endocrin. Pathol. 6, 253-256 (1995).
106. OSAMURA, R. Y., SANNO, N., TAHARA, S., KUROTANI, R., ITOH, Y., TERAMOTO, A.: Functional differentiation and its regulation in pituitary cells. - Acta histochem cytochem 31, 281-286 (1998).
107. OSAMURA, R. Y., TAHARA, S., KOMATSUBARA, K., ITOH, Y., KAJIWARA, H., KUROTANI, R., SANNO, N., TERAMOTO, A.: PIT-1 positive α-subunit positive non-functioning human pituitary adenomas: A dediferentiated a GH cell lineage? - Pituitary 1, 269-272 (1999).
108. OSAMURA, R. Y., TAHARA, S., KUROTANI, R., SANNO, N., MATSUNO, A., TERAMOTO, A.: Contributions of immunohistochemistry and in situ hybridization to functional analysis of pituitary adenomas. -J. histochem. cytochem. 48, 445-458 (2000).
109. PELLEGRINI-BOUILLER, I., MANRIQUE, C., GUNZ, G., GRINO, M., ZAMORA, A. J., FIGARELLA-BRANGER, D., GRISOLI, F., JAQUET, P., ENJALBERT, A.: Expression of the members of the Ptx family of transcription factors in human pituitary adenomas. - J. clin Endocrinol. Metab. 84, 2212-2220 (1999).
110. PERNASETTI, F., TOLEDO, S. P., VASILYEV, V. V., HAYASHIDA, C. Y., COGAN, J. D., FERRARI, C., LOURENCO, D. M., MELLON, P. L.: Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. -J. clin Endocrinol. Metab. 85, 390-407 (2000).
111. PFAFFLE, R. W., KIM, C., BLANKENSTEIN, O., KENTRUP, H.: GH transcription factors. -J. Pediatr. Endocrinol. Metab. 12 (Suppl.) 1, 311-317 (1999).
112. PLUMMER, T. B., SPERRY, A. C., XU, H., ELOYD, R. V.: In situ hybridization detection of low copy nucleic acid sequences using catalyzed reporter deposition and its usefulness in clinical human papillomavirus typing. - Diagn. mol. Pathol. 7, 76-84 (1998).
113. POMBO, C. M., ZALVIDE, J., GAYLINN, B. D., DIEGUEZ, C.: Growth hormone-releasing hormone stimulates mitogen-activated protein kinase. - Endocrinology 141, 2113-2119 (2000).
114. POULIN, G., LEBEL, M., CHAMBERLAND, M., PARADIS, F. W., DROUIN, J.: Specific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family. - Mol. Cell Biol. 20, 4826-37 (2000).
115. RADOVICK, S., NATIONS, M., DU, Y., BERG, E. A., WEINTRAUB, B. D., WONDISFORD, F. E.: A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257, 1115-1118 (1992).
116. REDECKER, P., CETIN, Y., GRUBE, D.: Differential distribution of synaptotagmin I and rab3 in the anterior pituitary of four mammalian species. - Neuroendocrinol. 62, 101-110 (1995).
117. SANNO, N., INADA, K., UMEMURA, S., ITOH, Y., MATSUNO, A., TERAMOTO, A., OSAMURA, R. Y.: Expression of Pit-1 product in human pituitaries: histochemical studies using an antibody against synthetic human Pit-1 protein. Med. - Sci. Res. 22, 685-687 (1994).
118. SANNO, N., JIN, E., QIAN, X., OSAMURA, R. Y., SCHEITHAUER, B. W., KOVACS, K., LLOYD, R. V.: Gonadotropin releasing hormone mRNA and Gonadotropin releasing hormone receptor mRNA expression in pituitaries and pituitary adenomas. -J. clin Endocrinol. Metab. 82, 1974-1982 (1997).
119. SANNO, N., MATSUNO, A., ITOH, J., KAKIMOTO, K., TERAMOTO, A., OSAMURA, R. Y: Combined Non-isotopic in situ hybridization method and indirect immunohistochemical analysis of hormone production in rat pituitary. -J. clin Pathol. Mol. Pathol. 49, M57-M60 (1996).
120. SANNO, N., MATSUNO, A., TAKEKOSHI, S., TERAMOTO, A., ITOH, J., ITOH, Y., OSAMURA, R. Y., WATANABE, K.: Messenger RNA and hormonal expression detected by combined non-radioisotopic in situ hybridization and immunohistochemistry in pituitaries and pituitary adenomas. - Cell Vision 2, 265 (1995).
121. SANNO, N., OSAMURA R. Y.: Catalyzed reporter deposition method for amplifying endocrine products. - Endocr. Pathol. 9, 195-199 (1998).
122. SANNO, N., SUGAWARA, A., TAHARA, S., OSAMURA, R. Y., TERAMOTO, A.: Retinoid X receptors (RXRs) mRNA expression in human pituitary adenomas. - Endocr. Pathol. 10, 73-83 (1999).
123. SANNO, N., SUGAWARA, A., TERAMOTO, A., ABE, Y., YEN, P. M., CHIN, W. W., OSAMURA, R. Y.: Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. - Neuro-endocrinol. 65, 299-306 (1997).
124. SANNO, N., TERAMOTO, A., MATSUNO, A., ITOH, J., OSAMURA, R. Y.: Clinical and histochemical analysis on TSH-secreting adenomas: Its muldhormonality and expression of Pit-1. - Modern Pathol. 7, 893-897 (1994).
125. SANNO, N., TERAMOTO, A., MATSUNO, A., TAKEKOSHI, S., ITOH, J., OSAMURA, R. Y.: Expression of Pit-1 and estrogen receptor messenger ribonucleic acids in prolactin producing pituitary adenomas:Non-radioisotopic in situ hybridization analysis. - Modern Pathol. 9, 526-533 (1996).
126. SANNO, N., TERAMOTO, A., MATSUNO, A., TAKEKOSHI, S., OSAMURA, R. Y.: Studies on GH and PRL gene expression by Non-radioisotopic in situ hybridization in TSH-secreting pituitary adenomas. -J. clin Endocrinol. Metab. 80, 2518-2522 (1995).
127. SANNO, N., TERAMOTO, A., MATSUNO, A., TAKEKOSHI, S., OSAMURA, R. Y.: Expression of Pit-1 product in human pituitary adenomas. Histochemical studies by antibody against synthetic human Pit-1. - Arch. Pathol. Lab. Med. 120, 73-77 (1996).
128. SANNO, N., TERAMOTO, A., MATSUNO, A., TAKEKOSHI, S., OSAMURA, R. Y.: In situ hybridizaytion analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas. - Acta Neuropathol. 91, 263-268 (1996).
129. SANNO, N., TERAMOTO, A., OSAMURA, R. Y., GENKA, S., KATAKAMI, H., JIN, L., LLOYD, R. V., KOVACS, K.: A growth hormone- releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. - J. clin Endocrinol. Metab. 82, 2731-2737 (1997).
130. SANNO, N., TERAMOTO, A., SUGIYAMA, M., ITOH, Y., OSAMURA, R. Y.: Application of CSA in immunodetection of gonadotropin subunits in clinically non-functioning pituitary adenomas. - Am. J. clin Pathol. 106, 16-21 (1996).
131. SANNO, N., TERAMOTO, A., OSAMURA, R. Y.: Clinical and cytofunctional classification of pituitary adenomas. - Acta neurochir. (Wien) 138, 1186-1192 (1996).
132. SCULLY, K. M., GLEIBERMAN, A. S., LINDZEY, J., LUBAHN, D. B., KORACH, K. S., ROSENFELD, M. G.: Role of estrogen receptor-alpha in the anterior pituitary gland. - Mol. Endocrinol. 11, 674-81 (1997).
133. SEIDAH, N. G., CHRETIEN, M.: Proprotein and prohormone convertases of the subtilisn family: recent developments and future perspectives. - Trends Endocrinol. Metab. 3, 133-140 (1992).
134. SEMINA, E. V., REITER, R., LEYSENS, N. J., ALWARD, W. L., SMALL, K. W., DATSON, N. A., SIEGEL-BE\ARTELT, J., BIERKE-NELSON, D., BITOUN, P., ZABEL, B. U. et al: Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. - Nat. Genet. 14, 392-399 (1996).
135. SHENG, H. Z., WESTPHAL, H.: Early steps in pituitary organogenesis. - Trends Genet. 15, 236-40 (1999).
136. SHI, S. R., KEY, M. E., KALRA, K. L.: Antigen retrieval in formalin-fixed paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. -J. Histochem. Cytochem. 39, 741-748 (1991).
137. SHIBUYA, M., ITO, S., MIWA, T., DAVIS, R. L., WILSON, C. B., HOSHINO, T: Proliferative potential of brain tumors. Analyses with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nuclear organizer region counts. - Cancer. 71, 199-206 (1993).
138. SIMMONS, D. M., VOSS, J. W., INGRAHAM, H. A., HOLLOWAY, J. M., BROIDE, R. S., ROSENFELD, M. G., SWANSON, L. W.: Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. - Genes Devel. 4, 695-711 (1990).
139. SORNSON, M. W., WU, W., DASEN, J. S., FLYNN, S. E., NORMAN, D. J., O'CONNELL, S. M., GUKOVSKY, I., CARRIERE, C., RYAN, A. K., MILLER, A. P., ZUO, L., GLEIBERMAN, A. S., ANDERSEN, B., BEAMER, W. G., ROSENFELD, M. G.: Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. - Nature 384 (6607), 327-33 (1996).
140. STEFANEANU, L., KOVACS, K., LLOYD, R. V., SCHEITHAUER, B. W., YOUNG, W. F. JR., SANO, T., JIN, L.: Pituitary lactotrophs and somatotrophs in pregnancy: A correlative in situ hybridization and immunocytochemical study. - Virchows Arch. (B) 62, 291-296 (1992).
141. STEINER, D. F., CUNNINGHAM, D., SPIEGELMAN, L., ATEN, B.: Insulin biosynthesis: evidence for a a precursor. - Science 157, 697-700 (1967).
142. STERNBERGER, L. A., HARDT, P. H. JR., CUCULIS, J. J. et al: The unlabeled antibody method of immunocytochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-andhorseradish peroxidase) and its use in the identification of spirochetes. - J. Histochem. Cytochem. 18, 315-333 (1970).
143. SUGAWARA, A., SANNO, N., TAKAHASHI, N., OSAMURA, R. Y., ABE, K.: Retinoid X receptors in the kidney: Their protein expression and funcional significance. - Endocrinol 65, 299-306 (1997).
144. SZETO, D. P., RODRIGUEZ-ESTEBN, C., RYAN, A. K., O'CONNELL, S. M., LIU, F., KIOUSSI, C., GLEIBEMAN, A. S., IZPISUA-BELMONTE, J. C., ROSENFELD, M. G.: Role of the bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. - Genes Dev. 15, 484-494 (1999).
145. TAHARA, S., KUROTANI, R., SANNO, N., TAKUMI, I., YOSHIMURA, S., OSAMURA, R. Y., TERAMOTO, A.: Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituary adenomas. - Mod Pathol. 13, 1097-1108 (2000).
146. TAHARA, S., SANNO, N., TERAMOTO, A., OSAMURA, R. Y.: Expression of Rab3, a Ras-related GTP-binding protein, In human nontumorous pituitaries and pituitary adenomas. - Modern Pathol. 12, 627-634 (1999).
147. TAKUMI, I., STEINER, D. F., SANNO, N., TERAMOTO, A., OSAMURA, R. Y.: Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: Analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy. - Modern Pathol. 11, 232-238 (1998).
148. TAYLOR, C. R., SHI, S.-R., CHAIWUN, B. et al.: Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: Androgen reiceptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques. - Hum. Pathol. 25, 263-270 (1994).
149. THERRIEN, M., DROUIN, J.: Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. - Mol. Cell Biol. 13, 2342-2353 (1993).
150. TREIER, M., GLEIBERMAN, A. S., O'CONNELL, S. M., SZETO, D. P., MCMAHON, J. A., MCMAHON, A. P., ROSENFELD, M. G.: Multistep signaling requirements for pituitary organogenesis in vivo. - Genes Dev. 12, 1691-1704 (1998).
151. TREMBLAY, J. J., MARCIL, A., GAUTHIER, Y., DROUIN, J.: Ptxl regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. - EMBO J. 5, 3431-41 (1995).
152. TSUTSUMI, Y., SERIZAWA, A., KAWAI, K.: Enhanced polymer one-step staining (EPOS) for proliferating cell nuclear antigen (PCNA) and Ki-67 antigen: application to intra-operative frozen diagnosis. - Pathol. int. 45, 108-115 (1995).
153. WAKABAYASHI, I., INOKUSHI, K., HASEGAWA, O., SUGIHARA, H., MINAMI, S.: Expression of growth hormone (GH) releasing factor gene in GH-producing pituitary adenoma. - J. clin Endocrinol. Metab. 74, 357-361 (1992).
154. WARNER, M., NILSSON, S., GUSTAFSSON, J. A.: The estrogen receptor family. - Curr. Opin. Obstet. Gynecol. 11, 249-254 (1999).
155. WU, W., COGAN, J. D., PFAFFLE, R. W: Mutations in PROP1 cause familial pituitary hormone deficiency.-Nat. Genet. 18, 147-149 (1998).
156. YU, V. C., DELSERT, C., ANDERSEN, B.: RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone and vitamin D receptors to their cognate response elements. - Cell 67, 1251-1266 (1991).
157. ZAHRAOUI, A., TOUCHOT, N., CHARDIN, P., TAVITIAN, A.: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. - J. biol. Chem. 264, 12394-12401 (1989).
158. ZEHBE, I., HACKER, G. W., SU, H., HAUSER-KRONBERGER, C., HAINFELD, J. E., TUBBS, R.: Sensitive in situ hybridization with catalyzed reporter deposition, streptoavidin-nanogold, and silber acetate autometallography. Detection of single-copy human papillomavirus. - Am. J. Pathol. 150, 1553-1561 (1997).
159. ZHANG, X.-K., HOFFMANN, B., TRAN, P. B.-V., GRAUPNER, G., PFAHL, M.: Retinoid X receptor is an auxillary protein for thyroid hormone and retinoic acid receptors. - Nature 355, 441-446 (1992).