Optimization of the preparation of sonogenic phospholipids-based microbubbles by using central composite experimental design and response surface methodology

Yaoxue Xuebao

Volumn 43, Issue 8, 2008, Pages 862-867

  Zhao, Ying Zheng ^a   Lu, Cui Tao ^a   Mei, Xin Guo ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Central composite design; Contrast effect; Response surface methodology; Sonogenic phospholipids based microbubble

Indexed keywords

CONTRAST MEDIUM; DRUG CARRIER; MACROGOL DERIVATIVE; PHOSPHATIDYLCHOLINE; POLYSORBATE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; MALE; MICROBUBBLE; PARTICLE SIZE; RABBIT; ULTRASOUND;

ANIMALS; CONTRAST MEDIA; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG DESIGN; MALE; MICROBUBBLES; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; POLYETHYLENE GLYCOLS; POLYSORBATES; RABBITS; ULTRASONICS;

EID: 50249145287     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Blomley MJ, Cooke JC, Unger EC, et al. Microbubble contrast agents: a new era in ultrasound [J]. BMJ, 2001,322:1222-1225.
2. Schutt EG, Klein DH, Mattrey RM, et al. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals [J]. Angew Chem (Int Ed Engl), 2003,42:3218-3235.
3. Bokor D. Diagnostic efficacy of SonoVue [J]. Am J Cardiol, 2000,86:19G-24G.
4. Hasik MJ, Kim DH, Howle LE, et al. Evaluation of synthetic phospholipid ultrasound contrast agents [J]. Ultrasonics, 2002,40:973-982.
5. Taniyama Y, Tachibana K, Hiraoka K, et al. Local delivery of plasmid DNA into rat carotid artery using ultrasound [J]. Circulation, 2002,105:1233-1239.
6. Unger EC, Porter T, Culp W, et al. Therapeutic applications of lipid-coated microbubbles [J]. Adv Drug Deliv Rev, 2004,56:1291-1314.
7. Pitt WG, Husseini GA, Staples BJ. Ultrasonic drug delivery - a general review [J]. Expert Opin Drug Deliv, 2004,1:37-56.
8. Porter TR. Diagnostic and therapeutic utilization of microbubbles [J]. Acta Cardiol Sin, 2005,21:77-88.
9. Zhao YZ, Zhang Y, Mei XG. Progress on microbubble ultrasound contrast agent [J]. Foreign Med Sci (Pharm), 2003,30:298-302.
10. Stride E, Saffari N. Microbubble ultrasound contrast agents: a review [J]. Proc Inst Mech Eng (H), 2003, 217:429-447.
11. Porter TR, Xie F, Silver M, et al. Real-time perfusion imaging with low mechanical index pulse inversion Doppler imaging [J]. J Am Coll Cardiol, 2001,37:748-753.
12. Shimoni S, Zoghbi WA, Xie F, et al. Real-time assessment of myocardial perfusion and wall motion during bicycle and treadmill exercise echocardiography: comparison with singlephoton emission computed tomography [J]. J Am Coll Cardiol, 2001,37:741-747.
13. Oh S, Rheem S, Sim J, et al. Optimizing conditions for the growth of Lactobacillus casei YIT 9018 in tryptone-yeast extract-glucose medium by using response surface methodology [J]. Appl Environ Microbiol, 1995,61:3809-3814.
14. Ooijkaas LP, Wilkinson EC, Tramper J, et al. Medium optimization for spore production of Coniothyrium minitans using statistically based experimental designs [J]. Biotechnol Bioeng, 1999,64:92-100.
15. Ismail A, Soultani S, Ghoul M. Optimization of the enzymatic synthesis of butyl glucoside using response surface methodology [J]. Biotechnol Prog, 1998,14:874-878.
16. Escamilla EM, Dendooven L, Magana IP, et al. Optimization of gibberellic acid production by immobilized Gibberella fujikuroi mycelium in fluidized bioreactors [J]. J Biotechnol, 2000,76:147-155.
17. Li C, Bai J, Li W, et al. Optimization of conditions for bacteriocin extraction in PEG/salt aqueous two-phase systems using statistical experimental designs [J]. Biotechnol Prog, 2001,17:366-368.
18. Wu XG, Li G, Gao YL. Optimization of the preparation of nalmefene-loaded sustained-release microspheres using central composite design [J]. Chem Pharm Bull (Tokyo), 2006,54:977-981.