Optimization of the preparation of nalmefene-loaded sustained-release microspheres using central composite design

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 7, 2006, Pages 977-981

  Wu, Xiang Gen ^a,b   Li, Gao ^a   Gao, Yong Liang ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Central composite design response surface methodology; Microsphere; Nalmefene; Poly(lactic co glycolic acid)

Indexed keywords

MICROSPHERE; NALMEFENE; POLYGLACTIN; SORBITAN OLEATE;

ARTICLE; EMULSION; ENCAPSULATION; METHODOLOGY; MULTIPLE LINEAR REGRESSION ANALYSIS; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE;

DELAYED-ACTION PREPARATIONS; DRUG DESIGN; FORECASTING; GLYCOLATES; MICROSPHERES; MODELS, THEORETICAL; NALTREXONE;

EID: 33745700007     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.977     Document Type: Article

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