Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells

Journal of Cell Science

Volumn 121, Issue 15, 2008, Pages 2529-2539

  Movshovich, Natalia ^a   Fridman, Vladimir ^a   Gerson Gurwitz, Adina ^a   Shumacher, Inbal ^a   Gertsberg, Irena ^a   Fich, Alexander ^a,b   Hoyt, M Andrew ^c   Katz, Benjamin ^a   Gheber, Larisa ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anaphase B; Kinesin 5; Midzone; Slk19; Spo12

Indexed keywords

CELL CYCLE PROTEIN 20; DNA; KINESIN; KINESIN 5; PHOSPHOPROTEIN PHOSPHATASE CDC14; PROTEIN SLK19; SEPARASE;

ANAPHASE; ARTICLE; CELL ELONGATION; CELL MUTANT; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; GENE DELETION; GENE EXPRESSION; IN VITRO STUDY; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; YEAST CELL;

ANAPHASE; CELLS, CULTURED; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 50249143480     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.022996     Document Type: Article

References (58)

1. Barton, N. R. and Goldstein, L. S. (1996). Going mobile: microtubule motors and chromosome segregation. Proc. Natl. Acad. Sci. USA 93, 1735-1742.
2. Baudin, A., Ozier-Kalogeropoulos, O., Denouel, A., Lacroute, F. and Cullin, C. (1993). A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21, 3329-3330.
3. Blangy, A., Lane, H. A., d'Herin, P., Harper, M., Kress, M. and Nigg, E. A. (1995). Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83, 1159-1169.
4. Bloom, G. S. and Endow, S. A. (1995). Motor proteins 1, kinesins. Protein Profile 2, 1105-1171.
5. Bouck, D. C. and Bloom, K. S. (2005). The kinetochore protein Ndc10p is required for spindle stability and cytokinesis in yeast. Proc. Natl. Acad. Sci. USA 102, 5408-5413.
6. Buvelot, S., Tatsutani, S. Y., Vermaak, D. and Biggins, S. (2003). The budding yeast Ip11/Aurora protein kinase regulates mitotic spindle disassembly. J. Cell Biol. 160, 329-339.
7. Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M. and Nasmyth, K. (1998). An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93, 1067-1076.
8. D'Amours, D. and Amon, A. (2004). At the interface between signaling and executing anaphase-Cdc14 and the FEAR network. Genes Dev. 18, 2581-2595.
9. D'Avino, P. P., Savoian, M. S. and Glover, D. M. (2005). Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. J. Cell Sci. 118, 1549-1558.
10. Gheber, L., Koo, S. C. and Hoyt, M. A. (1999). Motile properties of the kinesin-related Cin8p spindle motor extracted from Saccharomyces cerevisiae cells. J. Biol. Chem. 274, 9564-9572.
11. Gietz, R. D. and Woods, R. A. (2002). Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol. 350, 87-96.
12. Gietz, R. D., Schiestl, R. H., Willems, A. R. and Woods, R. A. (1995). Studies on the transformation of intact yeast cells by the LiAc/ SS-DNA/PEG procedure. Yeast 11, 355-360.
13. Gordon, D. M. and Roof, D. M. (1999). The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar. J. Biol. Chem. 274, 28779-28786.
14. Goshima, G. and Vale, R. D. (2005). Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol. Biol. Cell 16, 3896-3907.
15. Hagan, I. and Yanagida, M. (1992). Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356, 74-76.
16. Heck, M. M., Pereira, A., Pesavento, P., Yannoni, Y., Spradling, A. C. and Goldstein, L. S. (1993). The kinesin-like protein KLP61F is essential for mitosis in Drosophila. J. Cell Biol. 123, 665-679.
17. Higuchi, T. and Uhlmann, F. (2005). Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature 433, 171-176.
18. Howard, J. and Hyman, A. A. (2003). Dynamics and mechanics of the microtubule plus end. Nature 422, 753-758.
19. Howard, J. and Hyman, A. A. (2007). Microtubule polymerases and depolymerases. Curr. Opin. Cell Biol. 19, 31-35.
20. Hoyt, M. A., Totis, L. and Roberts, B. T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517.
21. Hoyt, M. A., He, L., Loo, K. K. and Saunders, W. S. (1992). Two Saccharomyces cerevisiac kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 118, 109-120.
22. Kahana, J. A., Schnapp, B. J. and Silver, P. A. (1995). Kinetics of spindle pole body separation in budding yeast. Proc. Natl. Acad Sci. USA 92, 9707-9711.
23. Kapitein, L. C., Peterman, E. J., Kwok, B. H., Kim, J. H., Kapoor, T. M. and Schmidt, C. F. (2005). The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435, 114-118.
24. Kashina, A. S., Baskin, R. J., Cole, D. G., Wedaman, K. P., Saxton, W. M. and Scholey, J. M. (1996). A bipolar kinesin. Nature 379, 270-272.
25. Kashina, A. S., Rogers, G. C. and Scholey, J. M. (1997). The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation. Biochim. Biophys. Acta 1357, 257-271.
26. Khmelinskli, A., Lawrence, C., Roostalu, J. and Schiebel, E. (2007). Cdc14-regulated midzone assembly controls anaphase B. J. Cell Biol. 177, 981-993.
27. Kline-Smith, S. L. and Walczak, C. E. (2004). Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol. Cell 15, 317-327.
28. Le Guellec, R., Paris, J., Couturier, A., Roghi, C. and Philippe, M. (1991). Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. Mol. Cell. Biol. 11, 3395-3398.
29. Li, R. and Murray, A. W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
30. Mumberg, D., Muller, R. and Funk, M. (1994). Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22, 5767-5768.
31. Pan, J. and Chen, R. H. (2004). Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev. 18, 1439-1451.
32. Pearson, C. G., Maddox, P. S., Salmon, E. D. and Bloom, K. (2001). Budding yeast chromosome structure and dynamics during mitosis. J. Cell Biol. 152, 1255-1266.
33. Pereira, G. and Schiebel, E. (2003). Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science 302, 2120-2124.
34. Pinsky, B. A., Tatsutani, S. Y., Collins, K. A. and Biggins, S. (2003). An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ip11/Aurora protein kinase. Dev. Cell 5, 735-745.
35. Pinsky, B. A., Kong, C., Shokat, K. M. and Biggins, S. (2006). The Ip11-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat. Cell. Biol. 8, 78-83.
36. Roberts, B. T., Farr, K. A. and Hoyt, M. A. (1994). The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14, 8282-8291.
37. Roof, D. M., Meluh, P. B. and Rose, M. D. (1992). Kinesin-related proteins required for assembly of the mitotic spindle. J. Cell Biol. 118, 95-108.
38. Ross, K. E. and Cohen-Fix, O. (2004). A role for the FEAR pathway in nuclear positioning during anaphase. Dev. Cell 6, 729-735.
39. Saunders, W. S., Koshland, D., Eshel, D., Gibbons, I. R. and Hoyt, M. A. (1995). Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J. Cell Biol. 128, 617-624.
40. Schott, E. J. and Hoyt, M. A. (1998). Dominant alleles of Saccharomyces cerevisiae CDC20 reveal its role in promoting anaphase. Genetics 148, 599-610.
41. Schuyler, S. C., Liu, J. Y. and Pellman, D. (2003). The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J. Cell Biol. 160, 517-528.
42. Severin, F., Habermann, B., Huffaker, T. and Hyman, T. (2001). Stu2 promotes mitotic spindle elongation in anaphase. J. Cell Biol. 153, 435-442.
43. Sharp, D. J., McDonald, K. L., Brown, H. M., Matthies, H. J., Walczak, C., Vale, R. D., Mitchison, T. J. and Scholey, J. M. (1999). The bipolar kinesin, KLP61F, crosslinks mcrotubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J. Cell Biol. 144, 125-138.
44. Sherman, F., Fink, G. R. and Hicks, J. B. (1983). Methods in Yeast Genetics. NY: Cold Spring Harbor Press.
45. Stegmeier, F., Visintin, R. and Amon, A. (2002). Separase, polo kinase, the kinetochore protein S1k19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108, 207-220.
46. Straight, A. F., Sedat, J. W. and Murray, A. W. (1998). Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J. Cell Biol. 143, 687-694.
47. Sullivan, M., Lehane, C. and Uhlmann, F. (2001). Orchestrating anaphase and mitotic exit: separase cleavage and localization of S1k19. Nat. Cell. Biol. 3, 771-777.
48. Thomas, S. and Kaplan, K. B. (2007). A Bir1p-Sli15p kinetochore passenger complex regulates septin organization during anaphase. Mol. Biol. Cell 25, 25.
49. Touitou, I., Lhomond, G. and Pruliere, G. (2001). Boursin, a sea urchin bimC kinesin protein, plays a role in anaphase and cytokinesis. J. Cell Sci. 114, 481-491.
50. Tytell, J. D. and Sorger, P. K. (2006). Analysis of kinesin motor function at budding yeast kinetochores. J. Cell Biol. 172, 861-874.
51. Vader, G., Medema, R. H. and Lens, S. M. (2006). The chromosomal passenger complex: guiding Aurora-B through mitosis. J. Cell Biol. 173, 833-837.
52. Visintin, R., Stegmeier, F. and Amon, A. (2003). The role of the polo kmase Cdc5 in controlling Cdc14 localization. Mol. Biol. Cell 14, 4486-4498.
53. Wach, A., Brachat, A., Pohlmann, R. and Philippsen, P. (1994). New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808.
54. Widlund, P. O., Lyssand, J. S., Anderson, S., Niessen, S., Yates, J. R., 3rd. and Davis, T. N. (2006). Phosphorylation of the chromosomal passenger protein Bir1 is required for localization of Ndc10 to the spindle during anaphase and full spindle elongation. Mol. Biol. Cell 17, 1065-1074.
55. Winey, M., Goetsch, L., Baum, P. and Byers, B. (1991). MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. J. Cell Biol. 114, 745-754.
56. Zachariae, W., Shin, T. H., Galova, M., Obermaier, B. and Nasmyth, K. (1996). Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274, 1201-1204.
57. Zeng, X., Kahana, J. A., Silver, P. A., Morphew, M. K., McIntosh, J. R., Fitch, I. T., Carbon, J. and Saunders, W. S. (1999). SIk19p is a centromere protein that functions to stabilize mitotic spindles. J. Cell Biol. 146, 415-425.
58. Zhang, T., Lim, H. H., Cheng, C. S. and Surana, U. (2006). Deficiency of centromere-associated protein SIk19 causes premature nuclear migration and loss of centromeric elasticity. J. Cell Sci. 119, 519-531.