RUNX1 aberrations in ETV6/RUNX1-positive and ETV6/RUNX1-negative patients: Its hemato-pathological and prognostic significance in a large cohort (619 cases) of ALL

Pediatric Hematology and Oncology

Volumn 25, Issue 6, 2008, Pages 582-597

  Pais, Anurita Peter ^a   Amare Kadam, Pratibha S ^a,c   Raje, Gauri Chandrakant ^a   Banavali, Shripad ^a   Parikh, Purvish ^a   Kurkure, Purna ^a   Arora, Brijesh ^a   Gujral, Sumit ^b   Kumar, S Ashok ^b   Badrinath, Y ^b  

^a TATA MEMORIAL HOSPITAL   (India)

^b Department of Medical Oncology ^*  (India)

^c Dept Med Oncol Tata Mem H   (India)

Author keywords

Additional isolated aberrations; BCP ALL; ETV6 RUNX1; FISH

Indexed keywords

TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CHROMOSOME ABERRATION; COHORT ANALYSIS; FEMALE; FOLLOW UP; GENE DUPLICATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PROGNOSIS;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; INFANT; MALE; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS;

EID: 50249118268     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.1080/08880010802237450     Document Type: Article

References (51)

1. Pui CH, Evans WE. Acute lymphoblastic leukemia. New Engl J Med. 1998;339:605-615.
2. Rubnitz JE, Look AT. Molecular genetics of childhood leukemias. J Pediatr Hematol Oncol. 1998;20:1-11.
3. Rowley JD. The role of chromosome translocations in leukemogenesis. Semin Hematol. 1999;36:59-72.
4. Romana SP, Poirel H, Leconiat M, et al. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood. 1995;86:4263-4269.
5. Eguchi-Ishimae M, Eguchi M, Tanaka K, et al. Fluorescence in situ hybridization analysis of 12;21 translocation in Japanese childhood acute lymphoblastic leukemia. Jpn J Cancer Res. 1998;89:983-988.
6. Garcia-Sanz R, Alaejos I, Orfao A, et al. Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukemia in Spain. Br J Haematol. 1999;107:667-669.
7. Jamil A, Theil KS, Kahwash S, Ruymann FB, Klopfenstein KJ. TEL/AML-1 fusion gene: its frequency and prognostic significance in childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2000;122:73-78.
8. Ma SK, Wan TSK, Cheuk ATC, et al. Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study. Leukemia. 2001;15:1442-1447.
9. Park KU, She CJ, Shin HY, et al. Low incidence of TEL/AML1 fusion and TEL deletion in Korean childhood acute leukemia by extra-signal fluorescence in situ hybridization. Cancer Genet Cytogenet. 2001;126:73-77.
10. Jarasova M, Holzerova M, Mihal V, et al. Additional evidence of genetic changes in children with ALL and TEL/AML1 fusion gene. Leukemia. 2002;16:1873-1875.
11. Mikhail FM, Serry KA, Hatem N, et al. AML1 gene overexpression in childhood acute lymphoblastic leukemia. Leukemia. 2002;16:658-668.
12. Dovet-Guilbert N, Morel F, Bris MJ, et al. A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001). Cancer Genet Cytogenet. 2003;144:143-147.
13. Attarbashi A, Mann G, Konig M, et al. Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia. 2004;18:1611-1616.
14. Veiga LBA, Coser VM, Cavalli LR, et al. High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia and known clinical outcome in southern Brazil. Leukemia Res. 2004;28:1033-1038.
15. Zen PRG, Lima MC, Coser VM, et al. Prevalence of TEL/AML1 fusion gene in Brazilian pediatric patients with acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2004;151:68-72.
16. Alvarez Y, Coll MD, Ortega JJ, et al. Genetic abnormalities associated with the t(12;21) and their impact in the outcome of 56 patients with B-precursor acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2005;162:21-29.
17. Perez-Vera P, Montero-Ruiz O, Frias S, et al. Detection of ETV6 and RUNX1 gene rearrangements using fluorescence in situ hybridization in Mexican patients with acute lymphoblastic leukemia: experience at a single institution. Cancer Genet Cytogenet. 2005; 162:140-145.
18. Loh ML, Goldwasser MA, Silverman LB, et al. Prospective analysis of TEL/AML1 positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood. 2006; 107:4508-4513.
19. Liang DC, Chou TB, Chen JS, et al. High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan. Leukemia. 1996;10:991-993.
20. Morrow M, Horton S, Kioussis D, Brady H, Williams O. TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity. Blood. 2004;103:3890-3898.
21. Jiang X, Zhao Y, Chan WY, et al. TEL-AML1 and BCR-ABL: different leukemias, similar questions. Blood. 2004; 103: 3611-3612.
22. Andreasson P, Schwaller J, Anastasiadou E, Aster J, Gilliland D. The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo. Cancer Genet Cytogenet. 2001;130:93-104.
23. Ford A, Bennett C, Price C, Bruin M, Van Wering E. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci U S A. 1998;95:4584-4588.
24. McHale C, Wiemels J, Zhang L, et al. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chrom Cancer. 2003;37:36-43.
25. Wiemels JL, Cazzaniga G, Daniotti M, et al. Prenatal origin of acute lymphoblastic leukemia in children. Lancet. 1999;354:1499-1503.
26. Maia AT, Ford AM, Jalali GR, et al. Molecular tracking of leukemogenesis in a triplet pregnancy. Blood. 2001;98:478-482.
27. Harbott J, Viehmann S, Borkhardt A, Henze G, Lampert F. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood. 1997;90:4933-4937.
28. Seeger K, Adams HP, Buchwald D, et al. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia. The Berlin-Frankfurt-Munster Study Group. Blood. 1998;91:1716-1722.
29. Inamdar N, Kumar SA, Banavali SD, Advani S, Magrath I, Bhatia K. Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India. Int J Oncol. 1998;13:1319-1322.
30. Siraj AK, Kamat S, Gutierrez MI, et al. Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian children differ from the west. Leukemia. 2003;17:1192-1193.
31. Hill A, Mike AS, Cherian V, Parakutty K, Priya K, Gareth JM. The t(12;21) is underrepresented in childhood B-lineage acute lymphoblastic leukemia in Kerala, Southern India. Hematologica. 2005;90:414-416.
32. Magrath I, Shanta V, Advani S, et al. Treatment of acute lymphoblastic leukaemia in countries with limited resources; lessons from use of a single protocol in India over a twenty year period. Eur J Cancer. 2005;41:1570-1583.
33. Bandopadhya S, Chatterjee M, Banavali SD, et al. Antibodies against 9-O-acetylated sialic acids in childhood acute lymphoblastic leukemia: a two-year study with 186 samples following protocol MCP 943. Indian J Biochem Biophys. 2006;43:7-14.
34. Amare PS, Baisane C, Saikia T, Nair R, Gawade H, Advani S. Fluorescence in situ hybridization: a highly efficient technique of molecular diagnosis and prediction for disease course in patients with myeloid leukemias. Cancer Genet Cytogenet. 2001;131:125-134.
35. Pais A, Amare Kadam P, Raje G, et al. Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia. Leukemia Res. 2005;29:517-526.
36. Borkhardt A, Cazzaniega G, Viehmann S, et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Blood. 1997;90:571-577.
37. Rubnitz JE, Pui CH, Downing JR. The role of TEL fusion genes in pediatric leukemias. Leukemia. 1999;13:6-13.
38. Amare Kadam PS, Raje GC, Pais AP, Banavali S. Coexistence of ETV6/RUNX1 and MLL aberrations in B-cell precursor acute lymphoblastic leukemia discloses a small subclass of BCP-ALL. Cancer Genet Cytogenet. 2008;182:27-32.
39. Amare PS, Gladstone B, Vargese C, Pai S, Advani SH. Clinical significance of cytogenetic findings at diagnosis and in remission in childhood and adult acute lymphoblastic leukemia: experience from India. Cancer Genet Cytogenet. 1998;110:44-53.
40. Borowitz MJ, Rubnitz J, Nash M, Pullen DJ, Camitta B. Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a pediatric Oncology group study. Leukemia. 1998;12:1764-1770.
41. Raynaud S, Cave H, Beans M, Bastard S, Cacheux V, Grosgeorge J. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood. 1996;87:2891-2899.
42. Pui CH, Carroll AJ, Head D, et al. Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood. Blood. 1990;76:590-596.
43. Bakhshi S, Chitlur M, Cushing B. Near-triploid acute lymphoblastic leukemia with TEL/AML1 translocation. Indian Pediatr. 2004;41:403-405.
44. Raimondi SC, Zhou Y, Shurtleff SA, et al. Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome. Cancer Genet Cytogenet. 2006;169:50-57.
45. Dal Cin P, Atkins L, Ford C, et al. Amplification of AML1 in childhood acute lymphoblastic leukemias. Genes Chromosomes Cancer. 2001;30:407-409.
46. Soulier J, Trakhtenbrot L, Najfeld V, et al. Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup. Leukemia. 2003;17:1679-1682.
47. Niini T, Kanerva J, Vettenranta K, Saarinen-Pihkala UM, Knuutila S. AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemia. Haematologica. 2000;85:362-366.
48. Harrison CJ, Moorman AV, Barber KE, et al. Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study. Br. J Haematol. 2005;129:520-530.
49. Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C. New mechanisms of AML1 gene alteration in hematological malignancies. Leukemia. 2003;17:9-16.
50. Song WJ, Sullivan MG, Legare RD. et al. (Haploinsufficiency of CBFA2 (AML1) causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia (FPD/AML1). Nat Genet. 1999;23:166-175.
51. Barton K, Nucifora G. AML1 haploinsufficiency, gene dosage, and the predisposition to acute leukemia. Bioassays. 2000;22:214-218.