Coexistence of ETV6/RUNX1 and MLL aberrations in B-cell precursor acute lymphoblastic leukemia discloses a small subclass of BCP-ALL

Cancer Genetics and Cytogenetics

Volumn 182, Issue 1, 2008, Pages 27-32

  Amare Kadam, Pratibha S ^a   Raje, Gauri Chandrakant ^a   Pais, Anurita Peter ^a   Banavali, Shripad ^a  

^a TATA MEMORIAL HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; AML1 GENE; ARTICLE; B LYMPHOCYTE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; ETV6 GENE; FEMALE; GENE; GENE DELETION; GENE DUPLICATION; GENE LOSS; GENE MUTATION; GENE REARRANGEMENT; GENE TRANSLOCATION; GENETIC DISORDER; HUMAN; LEUKEMOGENESIS; MALE; MALIGNANT TRANSFORMATION; MLL GENE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; RUNX1 GENE; SCHOOL CHILD; SOUTHERN BLOTTING; TEL GENE; TELOMERE;

CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 40049111332     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2007.12.012     Document Type: Article

References (13)

1. Wiemels J.L., Ford A.M., Van Wering E.R., Postma A., and Greaves M. Protracted and variable latency of acute lymphoblastic leukemia after TEL/AML1 gene fusion in utero. Blood 94 (1999) 1057-1062
2. Jarosová M., Holzerova M., Mihál V., Blatnŷ J., Lakomá I., Trka J., Pikalová Z., Hrusák O., and Indrák K. Additional evidence of genetic changes in children with ALL and TEL/AML1 fusion gene. Leukemia 16 (2002) 1873-1875
3. Rothman R., Trakhtenbrot L., Bielorai B., Izraeli S., Ishoev G., Amariglio N., Rechavi G., and Toren A. Co-existence of multiple subclones in TEL-AML1 at diagnosis of acute lymphoblastic leukaemia in association with submicroscopic deletion of AML1. Br J Haematol 129 (2005) 491-498
4. DiMartino J.F., and Cleary M.L. MLL rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol 106 (1999) 614-626
5. Pais A., Amare Kadam P., Raje G., Sawant M., Kabre S., Jain H., Advani S., and Banavali S. Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia. Leuk Res 29 (2005) 517-526
6. Ford A.M., Ridge S.A., Cabrera M.E., Mahmoud H., Steel C.M., Chan L.C., and Greaves M. In utero rearrangements in trithorax-related oncogene in infant leukaemias. Nature 363 (1993) 358-360
7. Takeuchi S., Cho S.K., Seriu T., Koike M., Bartram C.R., Reiter A., Schrappe M., Takeuchi C., Taguchi H., and Koeffler H.P. Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia. Oncogene 18 (1999) 7387-7388
8. Webb J.C., Golovleva I., Simpkins A.H., Kempski H., Reeves B., Sturt N., Chessells J.M., and Brickell P.M. Loss of heterozygosity and microsatellite instability at the MLL locus are common in childhood acute lymphoblastic leukemia. Blood 94 (1999) 283-290
9. Pui C.H., Frankel L.S., Carroll A.J., Raimondi S.C., Shuster J.J., Head D.R., Crist W.M., Land V.J., Pullen D.J., and Steuber C.P. Clinical characteristics and treatment of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases. Blood 77 (1991) 440-447
10. Amare P., Gladstone B., Varghese C., Pai S., and Advani S. Clinical significance of cytogenetic findings at diagnosis and in remission in childhood and adult acute lymphoblastic leukemia: experience from India. Cancer Genet Cytogenet 110 (1999) 44-53
11. In: Shaffer L.G., and Tommerup N. (Eds). ISCN 2005: an international system for human cytogenetic nomenclature (2005) (2005), S. Karger, Basel
12. Harrison C.J., Cuneo A., Clark R., Johansson B., Lafage-Pochitaloff M., Mugneret F., Moorman A.V., Secker-Walker L.M., et al. European 11q23 Workshop participants. Ten novel 11q23 chromosomal partner sites. Leukemia 12 (1998) 811-822
13. Cuthbert G., Thompson K., Breese G., McCullough S., and Bown N. Sensitivity of FISH in detection of MLL translocations. Genes Chromosomes Cancer 29 (2000) 180-185