Prevalence of TEL/AML1 fusion gene in Brazilian pediatric patients with acute lymphoblastic leukemia

Cancer Genetics and Cytogenetics

Volumn 151, Issue 1, 2004, Pages 68-72

  Zen, P R G ^a   Lima, M C ^b   Coser, V M ^c   Silla, L ^d   Daudt, L ^d   Fernandes, M S ^e   Neumann, J ^f   Mattevi, M S ^a,g   Ortigara, R ^h   Paskulin, G A ^b,h  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Inst de Exames Geneticos Ltda   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^d HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^e PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^f Hospital Dom Vicente Scherer   (Brazil)

^g UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^h UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR RUNX1;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ALLELE; AML1 GENE; ARTICLE; BONE MARROW; BRAZIL; CANCER DIAGNOSIS; CHILD; CHILDHOOD CANCER; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DIPLOIDY; DNA PROBE; FEMALE; FUSION GENE; GENE; GENE DELETION; GENE FREQUENCY; HUMAN; HUMAN TISSUE; INFANT; KARYOTYPING; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TEL GENE; WILD TYPE;

BRAZIL; CHILD; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; MOLECULAR PROBES; ONCOGENE PROTEINS, FUSION; PLOIDIES; TRANSLOCATION, GENETIC;

EID: 2342630492     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2003.09.003     Document Type: Article

References (28)

1. Romana S.P., Poirel H., Leconiat M., Flexor M.A., Mauchauffé M., Jonveaux P., Macintyre E.A., Berger R., Bernard O.A. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood. 86:1995;4263-4269
2. Romana S.P., Mauchauffé M., Le Coniat M., Chumakov I., Le Paslier D., Berger R., Bernard O.A. The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood. 85:1995;3662-3670
3. Golub T.R., Barker G.F., Bohlander S.K., Hiebert S.W., Ward D.C., Bray-Ward P., Morgan E., Raimondi S.C., Rowley J.D., Gilliland D.G. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 92:1995;4917-4921
4. Borkhardt A., Cazzaniga G., Viehmann S., Valsecchi M.G., Ludwig W.D., Burci L., Mangioni S., Schrappe M., Riehm H., Lampert F., Basso G., Masera G., Harbott J., Biondi A. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Blood. 90:1997;571-577
5. Loh M.L., Silverman L.B., Young M.L., Neuberg D., Golub T.R., Sallan S.E., Gilliland D.G. Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia. Blood. 92:1998;4792-4797
6. Rubnitz J.E., Shuster J.J., Land V.J., Link M.P., Pullen D.J., Camitta B.M., Pui C.H., Downing J.R., Behm F.G. Case-control study suggests a favorable impact of TEL rearrangement in patients with B-lineage acute lymphoblastic leukemia treated with antimetabolite-based therapy: a Pediatric Oncology Group study. Blood. 89:1997;1143-1146
7. Uckun F.M., Pallisgaard N., Hokland P., Navara C., Narla R., Gaynon P.S., Sather H., Heerema N. Expression of TEL/AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia. Leuk Lymphoma. 42:2001;41-56
8. Lanza C., Volpe G., Basso G., Gottardi E., Barisone E., Spinelli M., Ricotti E., Cilli V., Perfetto F., Madon E., Saglio G. Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia. Br J Haematol. 97:1997;460-462
9. Jamil A., Theil K.S., Kahwash S., Ruymann F.B., Klopfenstein K.J. TEL/AML1 fusion gene: its frequency and prognostic significance in childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet. 122:2000;73-78
10. Seeger K., Adams H.P., Buchwald D., Beyermann B., Kremens B., Niemeyer C., Ritter J., Schwabe D., Harms D., Schrappe M., Henze G. TEL/AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia. Blood. 91:1998;1716-1722
11. Hubeek I., Ramakers-van Woerden N.L., Pieters R., Slater R., Beverloo H.B., van Wering E.R., Kamps W., Hählen K., Veerman A.J.P. TEL/AML1 fusion is not a prognostic factor in Dutch childhood acute lymphoblastic leukaemia. Br J Haematol. 113:2001;254-255
12. Tsang K.S., Li C.K., Chik K.W., Shing M.M.K., Tsoi W.C., Ling Ng M.H., Lau T.T., Leung Y., Yuen P.M.P. TEL/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong. Am J Hematol. 68:2001;91-98
13. Raynaud S., Cavé H., Baens M., Bastard C., Cacheux V., Grosgeorge J., Guidal-Giroux C., Guo C., Vilmer E., Marynen P., Grandchamp B. B. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood. 87:1996;2891-2899
14. Spathas D.H., Stewart J., Singer I.O., Theriault A., Bovey M., Connor J.M. Detection of t(12;21) in childhood acute lymphoblastic leukemia by fluorescence in situ hybridization. Cancer Genet Cytogenet. 110:1999;7-13
15. Andreasson P., Höglund M., Békássy A.N., Garwicz S., Heldrup J., Mitelman F., Johansson B. Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias. Eur J Haematol. 65:2000;40-51
16. Park K.U., She C.J., Shin H.Y., Ahn H.S., Kim C.J., Cho B.K., Cho H.I., Lee D.S. Low incidence of TEL/AML1 fusion and TEL deletion in Korean childhood acute leukemia by extra-signal fluorescence in situ hybridization. Cancer Genet Cytogenet. 126:2001;73-77
17. Mikhail F.M., Serry K.A., Hatem N., Mourad Z.I., Farawela H.M., El Kaffash D.M., Coignet L., Nucifora G. AML1 gene over-expression in childhood acute lymphoblastic leukemia. Leukemia. 16:2002;658-668
18. Yehuda-Gafni O., Cividalli G., Abrahmov A., Weintrob M., Neriah S.B., Cohen R., Abeliovich D. Fluorescence in situ hybridization analysis of the cryptic T(12;21)(p13;q22) in childhood B-lineage acute lymphoblastic leukemia. Cancer Genet Cytogenet. 132:2002;61-64
19. Martinez-Ramirez A., Urioste M., Contra T., Cantalejo A., Tavares A., Portero J.A., López-Ibor B., Bernacer M., Soto C., Cigudosa J.C., Benitez J. Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children acute lymphoblastic leukemia. Haematologica. 86:2001;1245-1253
20. Magalhães I.Q., Pombo-de-Oliveira M.S., Bennett C.A., Cordoba J.C., Dobbin J., Ford A.M., Greaves M.F. TEL-AML1 fusion gene frequency in paediatric acute lymphoblastic leukaemia in Brazil. Br J Haematol. 111:2000;204-207
21. ISCN. An international system for human cytogenetic nomenclature. Mitelman F. 1995;S. Karger, Basel
22. Romana S.P., Le Coniat M., Berger R. t(12;21): A new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosomes Cancer. 9:1994;186-191
23. McLean T.W., Ringold S., Neuberg D., Stegmaier K., Tantravahi R., Ritz J., Koeffler H.P., Tekeuchi S., Janssen J.W.G., Seriu T., Bartram C.R., Sallan S.E., Gilliland D.G., Golub T.R. TEL/AML1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood. 88:1996;4252-4258
24. Stegmaier K., Pendse S., Barker G.F., Bray-Ward P., Ward D.C., Montgomery K.T., Krauter K.S., Reynolds C., Sklar J., Donnelly M., Bohlander S.K., Rowley J.D., Sallan S.E., Gilliland D.G., Golub T.R. Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood. 86:1995;38-44
25. Ma S.K., Wan T.S.K., Cheuk A.T.C., Fung L.F., Chan G.C.F., Chan S.Y., Ha S.Y., Chan L.C. Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study. Leukemia. 15:2001;1442-1447
26. Loncarevic I.F., Roitzheim B., Ritterbach J., Viehmann S., Borkhardt A., Lampert F., Harbott J. Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion. Genes Chromosomes Cancer. 24:1999;272-277
27. Andreasson P., Johansson B., Strombeck B., Donner M., Mitelman F., Hoglund M. Childhood acute lymphoblastic leukaemia with ider(21)(q10)t(12;21) (p12;q22): a new recurrent abnormality showing ETV6/CBFA2 fusion. Br J Haematol. 98:1997;216-218
28. Hellman J.S., Rosenberg S.A. DeVita V.T. Cancer: principles and practice of oncology, 5th edition. 1999;Lippincott-Raven. [CD-Rom]