β-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol

Carcinogenesis

Volumn 22, Issue 2, 2001, Pages 315-320

  Blum, Carmen A ^a,b   Xu, Meirong ^a   Orner, Gayle A ^a,b   Fong, Arthur T ^a   Bailey, George S ^b   Stoner, Gary D ^c   Horio, David T ^d   Dashwood, Roderick H ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d St Francis Healthcare System of Hawaii   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 3 INDOLEMETHANOL; BETA CATENIN; CARCINOGEN; CHLOROPHYLL; CYCLIN D1; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; MYC PROTEIN; PROTEIN C JUN; SERINE; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CODON; COLON CANCER; COLON TUMOR; CONSENSUS SEQUENCE; CONTROLLED STUDY; DIET; EXPOSURE; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; MALE; NONHUMAN; ONCOGENE C MYC; PHOSPHORYLATION; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES; STATISTICS;

EID: 0035112690     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.2.315     Document Type: Article

References (37)

1. Cancer Statistics, 1999
2. Cancer-susceptibility genes. Gatekeepers and caretakers
3. Activation of β-Catenin-Tcf signaling in colon cancer by mutations in β-Catenin or APC
4. Mutational analysis of the APC/β-Catenin/Tcf pathway in colorectal cancer
5. β-Catenin mutations in cell lines established from human colorectal cancers
6. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
7. Two members of the Tcf family implicated in Wnt/β-catenin signaling during embryogenesis in the mouse
8. Functional interaction of β-catenin with the transcription factor LEF-1
9. Curbing the nuclear activities of β-catenin: Control over Wnt target gene expression
10. Wnt signaling and cancer
11. β-Catenin is a target for the ubiquitin-proteosome pathway
12. β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
13. Identification of c-MYC as a target of the APC pathway
14. Target genes of β-catenin-T-cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
15. β-Catenin regulates expression of cyclin D1 in colon carcinoma cell
16. Dietary factors and risk of colon cancer
17. Antimutagens and anticarcinogens: A survey of putative interceptor molecules
18. Progress in cancer chemoprevention: Perspectives on agent selection and short-term clinical intervention trials
19. Indole-3-carbinol: Anticarcinogen or tumor promoter in brassica vegetables?
20. Chlorophylls as anticarcinogens
21. Colon carcinogens: Their metabolism and mode of action
22. Carcinogenic heterocyclic amines in model systems and cooked foods: A review on formation, occurrence and intake
23. Overview of carcinogenic heterocyclic amines
24. Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats
25. Genetic changes induced by heterocyclic amines
26. High frequency of β-catenin (Ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat
27. β-Catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors
28. Frequent mutations of the rat β-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone
29. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4.5-f]quinoline
30. Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation
31. Analysis of EGFR, TCF-α, neu and c-myc in 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine-induced mammary tumors using RT-PCR
32. Expression of the immediate-early genes, c-fos, c-jun, and c-myc: A comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens
33. Different frequencies and patterns of β-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient-L-amino acid-defined diet in rats
34. min mouse model by 1,4-phenylene bis(methylene)selenocyanate
35. Induction of a β-catenin-LEF-1-complex by wnt-1 transforming mutants of β-catenin