Progress and limits of PrP gene selection policy

Veterinary Research

Volumn 39, Issue 4, 2008, Pages

  Dawson, Michael ^a   Moore, Richard C ^b   Bishop, Stephen C ^b  

^a National Scrapie Plan Administration Centre   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Concerns; Control; Genotyping; Limitations; Scrapie

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CORTICOSTEROID; CYSTATIN C; FATTY ACID BINDING PROTEIN; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 6; NEURON SPECIFIC ENOLASE; PRION PROTEIN; PROSTAGLANDIN E2; PROTEIN S100B; TAU PROTEIN;

ANALYTIC METHOD; AUTOPSY; BLOOD EXAMINATION; BOVINE SPONGIFORM ENCEPHALOPATHY; DIAGNOSTIC PROCEDURE; EXPERIMENTAL INFECTION; HUMAN; IMMUNOASSAY; IMMUNOHISTOLOGY; NONHUMAN; PRION; PRION DISEASE; PROTEIN FOLDING; REVIEW; SENSITIVITY AND SPECIFICITY; VARIANT CREUTZFELDT JAKOB DISEASE; WESTERN BLOTTING; ANIMAL; BREEDING; GENETIC SELECTION; GENETICS; SCRAPIE; SHEEP; UNITED KINGDOM;

ANIMALIA; BOVINAE; OVIS ARIES;

ANIMALS; BREEDING; GREAT BRITAIN; PRIONS; SCRAPIE; SELECTION (GENETICS); SHEEP;

EID: 50049133983     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1051/vetres:2007064     Document Type: Review

References (41)

1. Arsac J.N., Andréoletti O., Bilheude J.M., Lacroux C., Benestad S.L., Baron T., Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway, Emerging Infect. Dis. (2007) 13:58-65.
2. Arnold M., Meek C., Webb C.R., Hoinville L., Assessing the efficacy of a ram genotyping programme to reduce susceptibility to scrapie in Great Britain, Prev. Vet. Med. (2002) 56:227-249.
3. Baylis M., Chihota C., Stevenson E., Goldmann W., Smith A., Sivam K., Tongue S., Gravenor M.B., Risk of scrapie in British sheep of different prion protein genotype, J. Gen. Virol. (2004) 85:2735-2740.
4. Baylis M., McIntyre M., Transmissible spongiform encephalopathies: scrapie control under new strain, Nature (2004) 432:810-811.
5. Benestad S.L., Arsac J.N., Goldmann W., Nöremark M., Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology, Vet. Res. (2008) 39:19.
6. Bruce M.E., McConnell I., Fraser H., Dickinson A.G., The disease characteristics of different strains of scrapie in sinc congenic mouse lines - implications for the nature of the agent and host control of pathogenesis, J. Gen. Virol. (1991) 72:595-603.
7. Bruce M.E., Chree A., McConnell I., Wells G.A.H., Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier, Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1994) 343:405-411.
8. Bruce M.E., Boyle A., Cousens S., McConnell I., Foster J., Goldmann W., Fraser H., Strain characterization of natural sheep scrapie and comparison with BSE, J. Gen. Virol. (2002) 83:695-704.
9. Davies D.C., Kimberlin R.H., Selection of Swaledale sheep of reduced susceptibility to experimental scrapie, Vet. Rec. (1985) 116:211-214.
10. Dawson M., Genotyping service for Swaledale sheep, Vet. Rec. (1994) 134:583-584.
11. Dawson M., Hoinville L.J., Hosie B.D., Hunter N., Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie, Vet. Rec. (1998) 142:623-625.
12. Diaz C., Vitezica Z.G., Rupp R., Andréoletti O., Elsen J.M., Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapie in a Romanov flock, J. Gen. Virol. (2005) 86:849-857.
13. Dickinson A.G., Fraser H., Scrapie pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent, in: Slow virus infections of the central nervous system, Ter Meulen V., Katz M. (Eds.), Springer, New-York, USA, 1977, pp. 3-14.
14. Everest S.J., Thorne L., Barnicle D.A., Edwards J.C., Ellitt H., Jackman R., Hope J., Atypical prion protein in sheep brain collected during the British scrapie surveillance programme, J. Gen. Virol. (2006) 87:471-477.
15. Foster J.D., Hope J., Fraser H., Transmission of bovine spongiform encephalopathy to sheep and goats, Vet. Rec. (1993) 133:339-341.
16. Gonzales L., Jeffrey M., Siso S., Martin S., Bellworthy S.J., Stack M.J., Chaplin M.J., Davis L., Dalgleish M.P., Reid H.W., Diagnosis of preclinical scrapie in samples of rectal mucosa, Vet. Rec. (2005) 156:846-847.
17. Groschup M.H., Lacroux C., Buschmann A., Luhken G., Mathey J., Eiden M., Lugan S., Hoffmann C., Espinosa J.C., Baron T., Torres J.M., Erhardt G., Andréoletti O., Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France, Emerging Infect. Dis. (2007) 13:1201-1207.
18. Gubbins S., Roden J.A., Breeding programmes for TSE resistance in British sheep. II. Assessing the impact on the prevalence and incidence of scrapie, Prev. Vet. Med. (2006) 73:17-31.
19. Hernandez-Sanchez J., Waddington D., Wiener P., Haley C.S., Williams J.L., Genome-wide search for markers associated with bovine spongiform encephalopathy, Mamm. Genome (2002) 13:164-168.
20. Hunter N., Goldmann W., Foster J.D., Cairns D., Smith G., Natural scrapie and PrP genotype: case control studies in British sheep, Vet. Rec. (1997) 141:137-140.
21. Lloyd S.E., Onwuazor O.N., Beck J.A., Mallinson G., Farrall M., Targonski P., Collinge J., Fisher E.M.C., Identification of multiple quantitative trait loci linked to prion disease incubation period in mice, Proc. Natl. Acad. Sci. USA (2001) 98:6279-6283.
22. Lloyd S.E., Uphill J.B., Targonski P.V., Fisher E.M.C., Collinge J., Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice, Neurogenetics (2002) 4:77-81.
23. Lühken G., Buschmann A., Brandt H., Eiden M., Groschup M.H., Erhardt G., Epidemiological and genetical differences between classical and atypical scrapie cases, Vet. Res. (2007) 38:65-80.
24. Man N.W.Y., Lewis R.M., Boulton K., Villanueva B., Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations, Genet. Sel. Evol. (2007) 39:711-729.
25. Manolakou K., Beaton J., McConnell I., Farquar C., Manson J., Hastie N.D., Bruce M., Jackson I.J., Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice, Proc. Natl. Acad. Sci. USA (2001) 98:7402-7407.
26. Moreno C.R., Lantier F., Lantier I., Sarradin P., Elsen J.M., Detection of new quantitative trait loci for susceptibility to transmissible spongiform encephalopathies in mice, Genetics (2003) 165:2085-2091.
27. Moum T., Olsaker I., Hopp P., Moldal T., Valheim M., Moum T., Benestad S.L., Polymorphisms at codon 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases, J. Gen. Virol. (2005) 86:231-235.
28. O'Rourke K.I., Baszler T.V., Besser T.E., Miller J.M., Cutlip R.C., Wells G.A.H., Ryder S.J., Parish S.M., Hamir A.N., Cockett N.E., Jenny A., Knowles D.P., Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue, J. Clin. Microbiol. (2000) 38:3254-3259.
29. Parry H.B., in: Scrapie disease in sheep, Oppenheimer D.R. (Ed.), Academic Press, London, UK, 1983, pp. 31-59.
30. Pollott G.E., Stone D.G., The breeding structure of the British sheep industry, 2003, Defra publications, London, UK, 2004.
31. Roughsedge T., Villanueva B., Woolliams J.A., Determining the relationship between restorative potential and size of a gene bank to alleviate the risks inherent in a scrapie eradication breeding programme, Livest. Sci. (2006)100: 231-241.
32. Saunders G.C., Cawthraw S., Mountjoy S.J., Hope J., Windl O., PrP genotypes of atypical scrapie cases in Great Britain, J. Gen. Virol. (2006) 87:3141-3149.
33. Schreuder B.E.C., van Keulen L.J.M., Vromans M.E.W., Langeveld J.P.M., Smits M.A., Tonsillar biopsy and PrPSc detection in the preclinical diagnosis of scrapie, Vet. Rec. (1998) 142:564-568.
34. Scott M., Foster D., Mirenda C., Serban D., Coufal F., Wälchli M., Torchia M., Groth D., Carlson G., DeArmond S.J., Westaway D., Prusiner S.B., Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques, Cell (1989) 59:847-857.
35. Springbett A.J., MacKenzie K., Woolliams J.A., Bishop S.C., The contribution of genetic diversity to the spread of infectious diseases in livestock populations, Genetics (2003) 165:1465-1474.
36. Stephenson D.A., Chiotti K., Ebeling C., Groth D., DeArmond S.J., Prusiner S.B., Carlson G.A., Quantitative trait loci affecting prion incubation time in mice, Genomics (2000) 69:47-53.
37. Sweeney T., Hanrahan J.P., The evidence of associations between prion protein genotype and production, reproduction and health traits in sheep, Vet. Res. (2008) 39:28, in press.
38. Tongue S.C., Pfeiffer D.U., Warner R., Elliott H., Vilas V.D., Estimation of the relative risk of developing clinical scrapie: the role of prion protein (PrP) genotype and selection bias, Vet. Rec. (2006)158:43-50.
39. Warner R.G., Morris D., Dawson M., PrP genotype progression in flocks participating in the National Scrapie Plan for Great Britain, Vet. Rec. (2006) 159:473-479.
40. Will R.G., Ironside J.W., Zeidler M., Cousens S.N., Estibeiro K., Alperovitch A., Poser S., Pocchiari M., Hofman A., Smith P.G., A new variant of Creutzfeldt-Jakob disease in the UK, Lancet (1996) 347:921-925.
41. Zhang C., De Koning D.J., Hernandez-Sanchez J., Haley C.S., Williams J.L., Wiener P., Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy, Genetics (2004) 167:1863-1872.