PrP genotypes of atypical scrapie cases in Great Britain

Journal of General Virology

Volumn 87, Issue 11, 2006, Pages 3141-3149

  Saunders, G C ^a   Cawthraw, S ^a   Mountjoy, S J ^a   Hope, J ^a   Windl, O ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLALANINE; PRION PROTEIN;

ALLELE; ARTICLE; CODON; CONTROLLED STUDY; DNA SEQUENCE; GENE INSERTION; GENETIC RESISTANCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; INCIDENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCRAPIE; SHEEP DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

ALLELES; ANIMALS; CODON; DNA TRANSPOSABLE ELEMENTS; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HAPLOTYPES; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIONS; SCRAPIE; SHEEP; VARIATION (GENETICS);

ANIMALIA; OVIS ARIES;

EID: 33750255724     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81779-0     Document Type: Article

References (26)

1. Anonymous (2005). Opinion of the Scientific Panel on Biological Hazards on the request from the European Commission on classification of atypical transmissible spongiform encephalopathy (TSE) cases in small ruminants. EFSA J 276, 1-30.
2. Baylis, M. & Goldmann, W. (2004). The genetics of scrapie in sheep and goats. Curr Mol Med 4, 385-396.
3. Baylis, M. & McIntyre, K. M. (2004). Transmissible spongiform encephalopathies: scrapie control under new strain. Nature 432, 810-811.
4. Baylis, M., Chilhota, C., Stevenson, E., Goldmann, W., Smith, A., Sivam, K., Tongue, S. & Gravenor, M. B. (2004). Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol 85, 2735-2740.
5. Benestad, S. L., Sarradin, P., Thu, B., Schonheit, J., Tranulis, M. A. & Bratberg, B. (2003). Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec 153, 202-208.
6. ARR/ARR). J Gen Virol 85, 2727-2733.
7. Buschmann, A., Biacabe, A.-G., Ziegler, U., Bencsik, A., Madec, J.-Y., Erhardt G., Lühken, G., Baron, T. & Groschup, M. H. (2004b). Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid tests. J Virol Methods 117, 27-36.
8. Dawson, M., Hoinville, L. J., Hosie, B. D. & Hunter, N. (1998). Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Scrapie Information Group. Vet Rec 142, 623-625.
9. De Bosschere, H., Roels, S., Benestad, S. L. & Vanopdenbosch, E. (2004). Scrapie case similar to Nor98 diagnosed in Belgium via active surveillance. Vet Rec 155, 707-708.
10. Everest, S. J., Thorne, L., Barnicle, D. A., Edwards, J. C., Elliott, H., Jackman, R. & Hope, J. (2006). Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme. J Gen Virol 87, 471-477.
11. Gavier-Widen, D., Nöremark, M., Benestad, S., Simmons, M., Renström, L., Bratberg, B., Elvander, M. & af Segerstad, C. H. (2004). Recognition of the Nor98 variant of scrapie in the Swedish sheep population. J Vet Diagn Invest 16, 562-567.
12. Goldmann, W., Hunter, N., Smith, G., Foster, J. & Hope, J. (1994). PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 75, 989-995.
13. Goldmann, W., Baylis, M., Chihota, C., Stevenson, E. & Hunter, N. (2005). Frequencies of PrP gene haplotypes in British sheep flocks and the implications for breeding programmes. J Appl Microbiol 98, 1294-1302.
14. Heaton, M. P., Leymaster, K. A., Freking, B. A. & 7 other authors (2003). Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer. Mamm Genome 14, 765-777.
15. Houston, F., Goldmann, W., Chong, A., Jeffrey, M., González, L., Foster, J., Parnham, D. & Hunter, N. (2003). Prion diseases: BSE in sheep bred for resistance to infection. Nature 423, 498.
16. Ikeda, T., Horiuchi, M., Ishiguro, N., Muramatsu, Y., Kai-Uwe, G. D. & Shinagawa, M. (1995). Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan. J Gen Virol 76, 2577-2581.
17. Lee, I. Y., Westaway, D., Smit, A. F. A. & 10 other authors (1998). Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res 8, 1022-1037.
18. 171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep. Arch Virol 149, 1571-1580.
19. Madec, J.-Y., Simon, S., Lezmi, S., Bencsik, A., Grassi, J. & Baron, T. (2004). Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock. J Gen Virol 85, 3483-3486.
20. Moum, T., Olsaker, I., Hopp, P., Moldal, T., Valheim, M., Moum, T. & Benestad, S. L. (2005). Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J Gen Virol 86, 231-235.
21. Onnasch, H., Gunn, H. M., Bradshaw, B. J., Benestad, S. L. & Bassett, H. F. (2004). Two Irish cases of scrapie resembling Nor98. Vet Rec 155, 636-637.
22. Orge, L., Galo, A., Machado, C., Lima, C., Ochoa, C., Silva, J., Ramos, M. & Simas, J. P. (2004). Identification of putative atypical scrapie in sheep in Portugal. J Gen Virol 85, 3487-3491.
23. Prusiner, S. B. (1982). Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144.
24. Slate, J. (2005). Molecular evolution of the sheep prion protein gene. Proc Biol Sci 272, 2371-2377.
25. Wilesmith, J., Matthews, D. & Ryan, J. (2003). Summary of the results of scrapie surveillance in sheep in Great Britain: January 2002-March 2003. http://www.defra.gov.uk/animalh/bse/publications/ reports/SheepSurveyRpt.pdf
26. Wilesmith, J., Ryan, J., Del Rio Vilas, V. & Gubbins, S. (2004). Summary of the results of scrapie surveillance in sheep in Great Britain: April-December 2003. http://www.defra.gov.uk/animalh/bse/publications/ reports/SheepSurvey2.pdf