Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations

Genetics Selection Evolution

Volumn 39, Issue 6, 2007, Pages 711-729

  Man, Wing Young N ^a   Lewis, Ronald M ^b   Boulton, Kay ^c   Villanueva, Beatriz ^a  

^a SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c Meat and Livestock Commission   (United Kingdom)

Author keywords

Inbreeding; Prion; PrP selection; Scrapie; Sire referencing

Indexed keywords

ALLELE; DISEASE RESISTANCE; GENOTYPE; INBREEDING; PERFORMANCE ASSESSMENT; PROTEIN; SCRAPIE; SELECTION; SHEEP;

ALLELE; ANIMAL; ANIMAL HUSBANDRY; ARTICLE; BIOLOGICAL MODEL; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; INBREEDING; MALE; PRION; SCRAPIE; SHEEP;

ALLELES; ANIMAL HUSBANDRY; ANIMALS; FEMALE; GENE FREQUENCY; GENOTYPE; INBREEDING; MALE; MODELS, GENETIC; PRIONS; SCRAPIE; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 36849015383     PISSN: 0999193X     EISSN: 12979686     Source Type: Journal    
DOI: 10.1051/gse:2007027     Document Type: Article

References (28)

1. Alexander B.M., Stobart R.H., Russell W.C., O'Rourke K.I., Lewis G.S., Logan J.R., Duncan J.V., Moss G.E., The incidence of genotypes at codon 171 of the prion protein gene (PRNP) in five breeds of sheep and production traits of ewes associated with those genotypes, J. Anim. Sci. 83 (2005) 455-459.
2. Alfonso L., Parada A., Legarra A., Ugarte E., Arana A., The effects of selective breeding against scrapie susceptibility on the genetic variability of the Latxa Black-Faced sheep breed, Genet. Sel. Evol. 38 (2006) 495-511.
3. Arnold M., Meek C., Webb C.R., Hoinville L.J., Assessing the efficacy of a ram-genotyping programme to reduce susceptibility to scrapie in Great Britain, Prev. Vet. Med. 56 (2002) 227-249.
4. Baylis M., The Kafkaesque approach to scrapie control - A sense of impending danger, Vet. J. 173 (2007) 235-236.
5. Baylis M., McIntyre K.M., Scrapie control under new strain, Nature 432 (2004) 810-811.
6. Brandsma J.H., Janss L.L.G., Visscher A.H., Association between PrP genotypes and performance traits in an experimental Dutch Texel herd, Livest. Prod. Sci. 95 (2005) 89-94.
7. Brochard M., Palhière I., Astruc J.M., Barillet F., Bouix J., Bibé B., Dion F., Elsen J.M., Francois D., Griffon L., Jullien E., Leymarie C., Orlianges M., Pantano T., Perret G., Tiphine L., Tribon P., Use of the PrP major gene to select for scrapie resistance: Example of the 5 years intensive French breeding plan, in: Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, 13-18 August 2006, Belo Horizonte, CD-ROM communication no. 22-34.
8. de Vries F., Borchers N., Hamann H., Drögemüller C., Reinecke S., Lüpping W., Distl O., Associations between the prion protein genotype and performance traits of meat breeds of sheep, Vet. Rec. 155 (2004) 140-143.
9. Defra (Department for Environment, Food and Rural Affairs), http://www.defra.gov.uk/animalh/bse/othertses/scrapie/nsp/index.html [consulted: 05 June 2007].
10. Detwiler L.A., Baylis M., The epidemiology of scrapie, Rev. Sci. Tech. Off. Int. Epiz. 22 (2003) 121-143.
11. Drögemüller C., de Vries F., Hamann H., Leeb T., Distl O., Breeding German sheep for resistance to scrapie, Vet. Rec. 154 (2004) 257-260.
12. EC, Commission decision (2003/100/EC) of 13 February 2003 laying down minimum requirements for the establishment of breeding programmes for resistance to transmissible spongiform encephalopathies in sheep, Official Journal of the European Union, 14.2.2003, L41/41.
13. Eglin R.D., Warner R., Gubbins S., Sivam S.K., Dawson M., Frequencies of PrP genotypes in 38 breeds of sheep sampled in the National Scrapie Plan for Great Britain, Vet. Rec. 156 (2005) 433-437.
14. Fernández J., Roughsedge T., Woolliams J.A., Villanueva B., Optimisation of the sampling strategy for establishing a gene bank: storing PrP alleles following a scrapie eradication plan as a case study, Anim. Sci. 82 (2006) 813-822.
15. Gama L.T., Carolino M.I., Santos-Silva M.F., Pimenta J.A., Costa M.S., Prion protein genetic polymorphisms and breeding strategies in Portuguese breeds of sheep, Livest. Sci. 99 (2006) 175-184.
16. Hunter N., Molecular biology and genetics of scrapie in sheep, in: Piper L., Ruvinsky A. (Eds.), The Genetics of Sheep, CAB International, Wallingford, 1997, pp. 225-240.
17. Isler B.J., Freking B.A., Thallman R.M., Heaton M.P., Leymaster K.A., Evaluation of associations between prion haplotypes and growth, carcass, and meat quality traits in a Dorset x Romanov sheep population, J. Anim. Sci. 84 (2006) 783-788.
18. Lewis R.M., Simm G., Selection strategies in sire referencing schemes in sheep, Livest. Prod. Sci. 67 (2000) 129-141.
19. Man W.Y.N., Brotherstone S., Merrell B.G., Murray W.A., Villanueva B., Analysis of association between PrP genotypes and live weight and slaughter traits in an experimental flock of Swaledale sheep in Great Britain, Anim. Sci. 82 (2006) 607-614.
20. Man W.Y.N., Lewis R.M., Boulton K., Villanueva B. (2006) Genetic consequences of selecting on PrP genotypes on terminal sire and hill sheep breeds, in: Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, 13-18 August 2006, Belo Horizonte, CD-ROM communication no. 04-05.
21. Molina A., Juárez M., Rodero A., Merino sheep breed's genetic resistance to scrapie: Genetic structure and comparison of five eradication strategies, Prev. Vet. Med. 75 (2006) 239-250.
22. Roden J.A., Nieuwhof G.J., Bishop S.C., Jones D.A., Haresign W., Gubbins S., Breeding programmes for TSE resistance in British sheep I. Assessing the impact on prion protein (PrP) genotype frequencies, Prev. Vet. Med. 73 (2006) 1-16.
23. Roughsedge T., Villanueva B., Woolliams J.A., Determining the relationship between restorative potential and size of a gene bank to alleviate the risks inherent in a scrapie eradication breeding programme, Liv. Sci. 100 (2006) 231-241.
24. Sawalha R.M., Brotherstone S., Man W.Y.N., Conington J., Bunger L., Simm G., Villanueva B., Associations of polymorphisms of the ovine prion protein gene with growth, carcass and computer tomography traits in Scottish Blackface lambs, J. Anim. Sci. 85 (2007) 632-640.
25. Simm G., Genetic improvement of cattle and sheep, 1st edn., Farming Press, 1998.
26. Villanueva B., Pong-Wong R., Grundy B., Woolliams J.A., Potential benefit from using an identified major gene in BLUP evaluation with truncation and optimal selection, Genet. Sel. Evol. 31 (1999) 115-133.
27. Vitezica Z.G., Moreno C.R., Bouix J., Barillet F., Perret G., Elsen J.M., A study on associations between PrP genotypes and meat traits in French sheep breeds, Anim. Sci. 81 (2005) 325-330.
28. Windig J.J., Eding H., Moll L., Kaal L., Effects on inbreeding of different strategies aimed at eliminating scrapie sensitivity alleles in rare sheep breeds in The Netherlands, Anim. Sci. 79 (2004) 11-20.