The catalytic mechanism of indole-3-glycerol phosphate synthase (IGPS) investigated by electrospray ionization (tandem) mass spectrometry

Tetrahedron Letters

Volumn 49, Issue 41, 2008, Pages 5914-5917

  Czekster, Clarissa M ^a   Lapis, Alexandre A M ^b,d   Souza, Gustavo H M F ^c   Eberlin, Marcos N ^c   Basso, Luiz A ^a   Santos, Diógenes S ^a   Dupont, Jaïrton ^b   Neto, Brenno A D ^a,b  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ENAMINE; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; TRYPTAMINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CATALYSIS; CATALYST; CHEMICAL REACTION; CYCLIZATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TARGETING; TANDEM MASS SPECTROMETRY;

MAMMALIA; MYCOBACTERIUM TUBERCULOSIS;

EID: 50049114926     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.07.149     Document Type: Article

References (23)

1. Raviglione M.C., and Smith I.M. New Engl. J. Med. 356 (2007) 656
2. World Health Organization. Surveillance, planning, financing, WHO Report, Geneva, Switzerland, WHO/HTM/TB/2005.349, 2005.
3. Smith D.A., Parish T., Stoker N.G., and Bancroft G.J. Infect. Immun. 69 (2001) 1142
4. Ducati R.G., Ruffino-Netto A., Basso L.A., and Santos D.S. Mem. Inst. Oswaldo Cruz 101 (2006) 697
5. Maartens G., and Wilkinson R.J. Lancet 370 (2007) 2030
6. Pablos-Mendez A., Raviglione M.C., Laszlo A., Binkin N., Rieder H.L., Bustreo F., Cohn D.L., Lambregts-van Weezenbeek C.S.B., Kim S.J., Chaulet P., and Nunn P. New Engl. J. Med. 338 (1998) 1641
7. Deng H., Murkin A.S., and Schramm V.L. J. Am. Chem. Soc. 128 (2006) 7765
8. Lee C.E., Goodfellow C., Javid-Majd F., Baker E.N., and Lott J.S. J. Mol. Biol. 355 (2006) 784
9. Parry R.J. In: Houlihan W.J. (Ed). Chemistry of Heterocyclic Compounds in Indoles, Part II Vol. 25 (1972), Wiley-Interscience, New York pp 1-64
10. Shivakumar D.M., and Bruice T.C. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 14379
11. Altamirano M.M., Blackburn J.M., Aguayo C., and Fersht A.R. Nature 403 (2000) 617
12. Eberlin M.N. Eur. J. Mass Spectrom. 13 (2007) 18
13. Hsu F.F., Turk J., Owens R.M., Rhoades E.R., and Russell D.G. J. Am. Soc. Mass Spectrom. 18 (2007) 466
14. Knight W.B., Swiderek K.M., Sakuma T., Calaycay J., Shively J.E., Lee T.D., Covey T.R., Shushan B., Green B.G., Chabin R., Shah S., Mumford R., Dickinson T.A., and Griffin P.R. Biochemistry 32 (1993) 2031
15. Kirschner K., Szadkowski H., Jardetzky T.S., and Hager V. Methods Enzymol. 142 (1987) 386
16. Hennig M., Darimont B.D., Jansonius J.N., and Kirschner K. J. Mol. Biol. 319 (2002) 757
17. ESI mass and tandem mass spectra in positive ion modes were acquired using a Micromass (Manchester-UK) QTof instrument of ESI-QTOF configuration with 7.000 mass resolving power in the TOF mass analyzer. The following typical operating conditions were used: 3 kV capillary voltage, 20 V cone voltage, dessolvation gas temperature of 110 °C.
18. Lapis A.A.M., Neto B.A.D., Scholten J.D., Nachtigall F.M., Eberlin M.N., and Dupont J. Tetrahedron Lett. 47 (2006) 6775
19. Santos L.S., Neto B.A.D., Consorti C.S., Pavam C.H., Almeida W.P., Coelho F., Eberlin M.N., and Dupont J. J. Phys. Org. Chem. 19 (2006) 731
20. Neto B.A.D., Lapis A.A.M., Mancilha F.S., Vasconcelos I.B., Thum C., Basso L.A., Santos D.S., and Dupont J. Org. Lett. 9 (2007) 4001
21. Russowsky D., and Neto B.A.D. Tetrahedron Lett. 44 (2003) 2923
22. Russowsky D., and Neto B.A.D. Tetrahedron Lett. 45 (2004) 1437-1440
23. Pilli R.A., Robello L.G., Camilo N.S., Dupont J., Lapis A.A.M., and Neto B.A.D. Tetrahedron Lett. 47 (2006) 1669