Computational mutagenesis of E. coli lac repressor: Insight into structure-function relationships and accurate prediction of mutant activity

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Volumn 4983 LNBI, Issue , 2008, Pages 390-401

  Masso, Majid ^a   Hijazi, Kahkeshan ^a   Parvez, Nida ^a   Vaisman, Iosif I ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

Computational mutagenesis; Lac repressor Delaunay tessellation; Statistical potential; Supervised learning

Indexed keywords

AMINES; AMINO ACIDS; BIOCOMMUNICATIONS; BIOINFORMATICS; DECISION MAKING; DECISION THEORY; DECISION TREES; ESCHERICHIA COLI; INFORMATION SCIENCE; KNOWLEDGE BASED SYSTEMS; LEARNING ALGORITHMS; MUTAGENESIS; ORGANIC ACIDS; WATER POLLUTION;

ACCURATE PREDICTION; AMINO ACID RESIDUES; COMPUTATIONAL MUTAGENESIS; CONTACT POTENTIALS; DECISION TREE MODELS; DECISION-TREE ALGORITHMS; E. COLI; ENVIRONMENTAL PERTURBATIONS; INTERNATIONAL SYMPOSIUM; KNOWLEDGE-BASED; LAC REPRESSOR; LAC REPRESSOR DELAUNAY TESSELLATION; PROTEIN ACTIVITIES; RECEIVER OPERATING CHARACTERISTIC CURVE; STATISTICAL POTENTIAL; STRUCTURE COMPATIBILITY; STRUCTURE-FUNCTION RELATIONSHIPS; SUPERVISED LEARNING;

TREES (MATHEMATICS);

EID: 50049112122     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-540-79450-9_36     Document Type: Conference Paper

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