Placental transfer and fetal elimination of morphine-3-β-glucuronide in the pregnant baboon

Drug Metabolism and Disposition

Volumn 36, Issue 9, 2008, Pages 1859-1868

  Garland, Marianne ^a,b   Abildskov, Kirsten M ^a   Kiu, Tung Wah ^a   Daniel, Salha S ^a   Weldy, Piper ^a   Stark, Raymond I ^a  

^a Howard Hughes Medical Institute   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE 3 GLUCURONIDE; MORPHINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BABOON; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PENETRATION; FEMALE; FETUS; FETUS BLOOD; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FETUS; GLUCURONIDES; HALF-LIFE; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; MORPHINE; PAPIO; PLACENTA; PREGNANCY;

PAPIO; PRIMATES;

EID: 50049092902     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.021352     Document Type: Article

References (43)

1. Adachi Y, Suzuki H, Schinkel AH, and Sugiyama Y (2005) Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Mol Pharmacol 67:923-928.
2. Caspersen CS, Reznik B, Weldy PL, Abildskov KM, Stark RI, and Garland M (2007) Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family: evolution of the primate UGT1 locus and relevance for models of human drug metabolism. Pharmacogenet Genomics 17:11-24.
3. Daniel SS, James LS, MacCarter G, Morishima HO, and Stark RI (1992) Long-term acid-base measurements in the fetal and maternal baboon. Am J Obstet Gynecol 166:707-712.
4. Enders AC and Carter AM (2004) What can comparative studies of placental structure tell us? - a review. Placenta 25 (Suppl A):S3-S9.
5. Evseenko DA, Paxton JW, and Keelan JA (2006) ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol 290:R1357-R1365.
6. Faber JJ, Thornburg KL, and Binder ND (1992) Physiology of placental transfer in mammals. Am Zool 32:343-354.
7. Garland M, Abildskov K, Daniel SS, and Stark RI (2001) Distribution of morphine and its metabolites in the fetal baboon. Pediatr Res 49:453A.
8. Garland M, Abildskov KM, Kiu TW, Daniel SS, and Stark RI (2005) The contribution of fetal metabolism to the disposition of morphine. Drug Metab Dispos 33:68-76.
9. Garland M, Abildskov KM, Taylor S, Benzeroual K, Caspersen CS, Arroyo SE, Kiu TW, Reznik B, Weldy P, Daniel SS, et al. (2006) Fetal morphine metabolism and clearance are constant during late gestation. Drug Metab Dispos 34:636-646.
10. Garland M, Myers MM, Szeto HH, and Stark RI (1996a) Maternal-fetal pharmacokinetics: the two-compartment model revisited (Abstract). Pediatr Res 39 (Suppl 2):73.
11. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1996b) Zidovudine kinetics in the pregnant baboon. J Acquir Immune Defic Syndr Hum Retrovirol 11:117-127.
12. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1998a) Implications of the kinetics of zidovudine in the pregnant baboon following oral administration. J Acquir Immune Defic Syndr Hum Retrovirol 19:433-440.
13. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1998b) Placental transfer and fetal metabolism of zidovudine in the baboon. Pediatr Res 44:47-53.
14. Garland M, Szeto HH, and Stark RI (1998c) The primate placenta is permeable to glucuronide metabolites (Abstract). Pediatr Res 43:59A.
15. Gerdin E, Gabrielsson J, Lindberg B, and Rane A (1990a) Disposition of morphine-3-glucuronide in the pregnant rhesus monkey. Pharmacol Toxicol 66:815-819.
16. Gerdin E, Rane A, and Lindberg B (1990b) Transplacental transfer of morphine in man. J Perinat Med 18:305-312.
17. Krishna R, Riggs KW, Kwan E, Wong H, Szeitz A, Walker MP, and Rurak DW (2002) Clearance and disposition of indomethacin in chronically instrumented fetal lambs following a 3-day continuous intravenous infusion. J Pharm Pharmacol 54:801-808.
18. Labella FS, Pinsky C, and Havlicek V (1979) Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity. Brain Res 174:263-271.
19. Liebes L, Mendoza S, Lee JD, and Dancis J (1993) Further observations on zidovudine transfer and metabolism by human placenta. AIDS 7:590-592.
20. Lötsch J, Weiss M, Kobal G, and Geisslinger G (1998) Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration. Clin Pharmacol Ther 63:629-639.
21. Maliepaard M, Scheffer GL, Faneyte IF, van Gastelen MA, Pijnenborg AC, Schinkel AH, van De Vijver MJ, Scheper RJ, and Schellens JH (2001) Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 61:3458-3464.
22. Nagashige M, Ushigome F, Koyabu N, Hirata K, Kawabuchi M, Hirakawa T, Satoh S, Tsukimori K, Nakano H, Uchiumi T, et al. (2003) Basal membrane localization of MRP1 in human placental trophoblast. Placenta 24:951-958.
23. Nishimura M and Naito S (2005) Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies. Drug Metab Pharmacokinet 20:452-477.
24. Nishino J, Suzuki H, Sugiyama D, Kitazawa T, Ito K, Hanano M, and Sugiyama Y (1999) Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein. J Pharmacol Exp Ther 290:289-294.
25. Odinecs A, Nosbisch C, Keller RD, Baughman WL, and Unadkat JD (1996) In vivo maternalfetal pharmacokinetics of stavudine (2′,3′-didehydro- 3′-deoxythymidine) in pigtailed macaques (Macaca nemestrina). Antimicrob Agents Chemother 40:196-202.
26. Olsen GD, Norris SR, Sommer KM, and Grosso SM (1989) Placental permeability for morphine-3-β-D-glucuronide in the guinea pig. Placenta 10:83-93.
27. Olsen GD, Sommer KM, Wheeler PL, Boyea SR, Michelson SP, and Cheek DB (1988) Accumulation and clearance of morphine-3-β-D-glucuronide in fetal lambs. J Pharmacol Exp Ther 247:576-584.
28. Pascolo L, Fernetti C, Pirulli D, Crovella S, Amoroso A, and Tiribelli C (2003) Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells. Biochem Biophys Res Commun 303:259-265.
29. Pasternak GW, Bodnar RJ, Clark JA, and Inturrisi CE (1987) Morphine-6-glucuronide, a potent mu agonist. Life Sci 41:2845-2849.
30. Schröder HJ (1995) Comparative aspects of placental exchange functions. Eur J Obstet Gynecol Reprod Biol 63:81-90.
31. Skarke C, Geisslinger G, and Lötsch J (2005) Is morphine-3- glucuronide of therapeutic relevance? Pain 116:177-180.
32. St-Pierre MV, Serrano MA, Macias RI, Dubs U, Hoechli M, Lauper U, Meier PJ, and Marin JJ (2000) Expression of members of the multidrug resistance protein family in human term placenta. Am J Physiol Regul Integr Comp Physiol 279:R1495-R1503.
33. Stark RI, Daniel SS, James LS, MacCarter G, Morishima HO, Niemann WH, Rey H, Tropper PJ, and Yeh MN (1989) Chronic instrumentation and longterm investigation in the fetal and maternal baboon: tether system, conditioning procedures and surgical techniques. Lab Anim Sci 39:25-32.
34. Szeto HH, Umans JG, and McFarland J (1982a) A comparison of morphine and methadone disposition in the maternal-fetal unit. Am J Obstet Gynecol 143:700-706.
35. Szeto HH, Umans JG, and Rubinow SI (1982b) The contribution of transplacental clearances and fetal clearance to drug disposition in the ovine maternal-fetal unit. Drug Metab Dispos 10:382-386.
36. Tuntland T, Odinecs A, Nosbisch C, and Unadkat JD (1998) In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens. J Pharmacol Exp Ther 285:54-62.
37. van de Wetering K, Zelcer N, Kuil A, Feddema W, Hillebrand M, Vlaming ML, Schinkel AH, Beijnen JH, and Borst P (2007) Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol 72:387-394.
38. Wang LH, Rudolph AM, and Benet LZ (1985) Distribution and fate of acetaminophen conjugates in fetal lambs in utero. J Pharmacol Exp Ther 235:302-307.
39. Wang LH, Rudolph AM, and Benet LZ (1986) Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. J Pharmacol Exp Ther 238:198-205.
40. Wang LH, Rudolph AM, and Benet LZ (1990) Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods. Dev Pharmacol Ther 14:161-179.
41. Xie R, Bouw MR, and Hammarlund-Udenaes M (2000) Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport. Br J Pharmacol 131:1784-1792.
42. Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Wright MR, Abbott FS, and Axelson JE (1993) Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration. J Pharmacol Exp Ther 267:425-431.
43. Zamek-Gliszczynski MJ, Nezasa K, Tian X, Kalvass JC, Patel NJ, Raub TJ, and Brouwer KL (2006) The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice. Mol Pharmacol 70:2127-2133.