Placental transfer and fetal metabolism of zidovudine in the baboon

Pediatric Research

Volumn 44, Issue 1, 1998, Pages 47-53

  Garland, Marianne ^a   Szeto, Hazel H ^b   Daniel, Salha S ^a   Tropper, Pamela J ^c   Myers, Michael M ^a   Stark, Raymond I ^a  

^a Columbia University ^*  (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; ZIDOVUDINE; ZIDOVUDINE GLUCURONIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG DISPOSITION; FETUS CIRCULATION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY COMPLICATION; PRIORITY JOURNAL; VERTICAL TRANSMISSION; VIRUS TRANSMISSION;

EID: 0031866433     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199807000-00008     Document Type: Article

References (30)

1. Connor EM, Mofenson LM 1995 Zidovudine for the reduction of perinatal human immunodeficiency virus transmission: pediatric AIDS Clinical Trials Group Protocol 076[em]results and treatment recommendations. Pediatr Infect Dis J 14:536-541
2. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL 1994 Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 331:1173-1180
3. Fast P, Newell M-L, Mofenson L, Ammann A, Rossi P, Siena Consensus Workshop II 1995 Strategies for prevention of perinatal transmission of HIV infection. J Acquir Immune Defic Syndr 8:161-175
4. Dickover RE, Garratty EM, Herman SA, Sim MS, Plaeger S, Boyer PJ, Keller M, Deveikis A, Stiehm ER, Bryson YJ 1996 Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission. Effect of maternal zidovudine treatment on viral load. JAMA 275:599-605
5. Sperling RS, Shapiro DE, Coombs RW, Todd JA, Herman SA, McSherry G, O'Sullivan MJ, Van Dyke RB, Jimenez E, Rouzioux C, Flynn PM, Sullivan JL 1996 Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N Engl J Med 335:1621-1629
6. Garland M, Stark RI, Szeto HH, Myers MM 1994 Exposure to zidovudine in the fetal baboon. Pediatr Res 35:84A
7. Lopez-Anaya A, Unadkat JD, Schumann LA, Smith AL 1990 Pharmacokinetics of zidovudine (azidothymidine). I. Transplacental transfer. J Acquir Immune Defic Syndr 3:959-964
8. Szeto HH, Umans JG, Rubinow SI 1982 The contribution of transplacental clearances and fetal clearance to drug disposition in the ovine maternal-fetal unit. Drug Metab Dispos 10:382-386
9. Coughtrie MW, Burchell B, Leakey JE, Hume R 1988 The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes. Mol Pharmacol 34:729-735
10. Dvorchik BH, Woodward G, Sitar DS, Tweed WA 1986 Hydroxylation and glucuronidation of various xenobiotics by hepatic microsomes from the fetal lamb, pregnant ewe and human fetus. Dev Pharmacol Ther 9:282-289
11. Olsen GD, Norris SR, Sommer KM, Grosso SM 1989 Placental permeability for morphine-3-β-D-glucuronide in the guinea pig. Placenta 10:83-93
12. Olsen GD, Sommer KM, Wheeler PL, Boyea SR, Michelson SP, Cheek DB 1988 Accumulation and clearance of morphine-3-β-D-glucuronide in fetal lambs. J Pharmacol Exp Ther 247:576-584
13. Stark RI, Daniel SS, James LS, MacCarter G, Morishima HO, Niemann WH, Rey H, Tropper PJ, Yeh MN 1989 Chronic instrumentation and longterm investigation in the fetal and maternal baboon: tether system, conditioning procedures and surgical techniques. Lab Anim Sci 39:25-32
14. Collins JM, Klecker RW, Jr., Kelley JA, Roth JS, McCully CL, Baus FM, Poplack DG 1988 Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluid. J Pharmacol Exp Ther 245:466-70
15. Liebes L, Mendoza S, Wilson D, Dancis J 1990 Transfer of zidovudine (AZT) by human placenta. J Infect Dis 161:203-207
16. Schenker S, Johnson RF, King TS, Schenken RS, Henderson GI 1990 Azidothymidine (zidovudine) transport by the human placenta. Am J Med Sci 299:16-20
17. Garland M, Szeto HH, Daniel SS, Tropper P, Myers MM, Stark RI 1996 Zidovudine kinetics in the pregnant baboon. J Acquir Immune Defic Syndr 11:117-127
18. Blum MR, Liao SH, Good SS, de Miranda P 1988 Pharmacokinetics and bioavailability of zidovudine in humans. Am J Med 85:189-194
19. Yoo SD, Rurak DW, Taylor SM, Axelson JE 1993 Transplacental and nonplacental clearances of diphenhydramine in the chronically instrumented pregnant sheep. J Pharm Sci 82:145-149
20. Szeto HH, Umans JG, McFarland J 1982 A comparison of morphine and methadone disposition in the maternal-fetal unit. Am J Obstet Gynecol 143:700-706
21. Riggs KW, Rurak DW, Taylor SM, McErlane BA, McMorland GH, Axelson JE 1990 Fetal and maternal placental and nonplacental clearances of metoclopramide in chronically instrumented pregnant sheep. J Pharm Sci 79:1056-1061
22. Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Wright MR, Abbott FS, Axelson JE 1993 Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration. J Pharmacol Exp Ther 267:425-431
23. Wang LH, Rudolph AM, Benet LZ 1986 Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. J Pharmacol Exp Ther 238:198-205
24. Dutton GJ, Leakey JEA 1981 The perinatal development of drug-metabolizing enzymes: what factors trigger their onset? Prog Drug Res 25:189-273
25. Valaes TN, Harvey-Wilkes K 1990 Pharmacologic approaches to the prevention and treatment of neonatal hyperbilirubinemia. Clin Perinatol 17:245-273
26. Nathenson G, Cohen MI, Litt IF, McNamara H 1972 The effect of maternal heroin addiction on neonatal jaundice. J Pediatr 81:899-903
27. Watts DH, Brown ZA, Tartaglione T, Burchett SK, Opheim K, Coombs R, Corey L 1991 Pharmacokinetic disposition of zidovudine during pregnancy. J Infect Dis 163:226-232
28. Sperling RS, Roboz J, Dische R, Silides D, Holzman I, Jew E 1992 Zidovudine pharmacokinetics during pregnancy. Am J Perinatol 9:247-249
29. O'Sullivan MJ, Boyer PJJ, Scott GB, Parks W, Weller S, Blum MR, Balsley J, Bryson YJ, Zidovudine Collaborative Working Group 1993 The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: Phase I Acquired Immunodeficiency Syndrome Clinical Trials Group study (protocol 082). Am J Obstet Gynecol 168:1510-1516
30. Chavanet P, Diquet B, Waldner A, Portier H 1989 Perinatal pharmacokinetics of zidovudine. N Engl J Med 321:1548-1549