Fetal morphine metabolism and clearance are constant during late gestation

Drug Metabolism and Disposition

Volumn 34, Issue 4, 2006, Pages 636-646

  Garland, Marianne ^a,b   Abildskov, Kirsten M ^a   Taylor, Samantha ^a   Benzeroual, Kenza ^a   Caspersen, Casper S ^a   Arroyo, Sylvia E ^a   Kiu, Tung Wah ^a   Reznik, Boris ^a   Weldy, Piper ^a   Daniel, Salha S ^a   Stark, Raymond I ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b PH4W 465 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; MORPHINE; MORPHINE 3 BETA GLUCURONIDE; MORPHINE 6 BETA GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BABOON; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; ENZYME INDUCTION; FETUS; FETUS GROWTH; FETUS LIVER; FETUS WEIGHT; GESTATION PERIOD; GLUCURONIDATION; LIVER CLEARANCE; METABOLIC CLEARANCE RATE; METABOLITE; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; FEMALE; FETUS; GESTATIONAL AGE; INFUSIONS, INTRAVENOUS; LIVER; METABOLIC CLEARANCE RATE; MORPHINE; MORPHINE DERIVATIVES; PAPIO; PLACENTA; PREGNANCY;

ANIMALIA; PAPIO; PAPIO HAMADRYAS;

EID: 33645104689     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.007567     Document Type: Article

References (52)

1. Adams EA, Choi HM, Cheung CY, and Brace RA (2005) Comparison of amniotic and intramembranous unidirectional permeabilities in late-gestation sheep. Am J Obstet Gynecol193:247-255.
2. Bellotti M, Pennati G, De Gasperi C, Battaglia FC, and Ferrazzi E (2000) Role of ductus venosus in distribution of umbilical blood flow in human fetuses during second half of pregnancy. Am J Physiol 279:H1256-H1263.
3. Berman W Jr, Goodlin RC, Heymann MA, and Rudolph AM (1975) Measurement of umbilical blood flow in fetal lambs in utero. J Appl Physiol 39:1056-1059.
4. Chay PC, Duffy BJ, and Walker JS (1992) Pharmacokinetic-pharmacodynamic relationships of morphine in neonates. Clin Pharmacol Ther 51:334-342.
5. Coffman BL, Rios GR, King CD, and Tephly TR (1997) Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos 25:1-4.
6. Connor EM and Mofenson LM (1995) Zidovudine for the reduction of perinatal human immunodeficiency virus transmission: pediatric AIDS Clinical Trials Group Protocol 076 - results and treatment recommendations. Pediatr Infect Dis J 14:536-541.
7. Coughtrie MW, Burchell B, Leakey JE, and Hume R (1988) The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes. Mol Pharmacol 34:729-735.
8. Daniel SS, James LS, MacCarter G, Morishima HO, and Stark RI (1992) Long-term acid-base measurements in the fetal and maternal baboon. Am J Obstet Gynecol 166:707-712.
9. Dvorchik BH, Stenger VG, and Hartman RD (1979) Drug metabolism by the fetal stump-tailed monkey (Macaca arctoides). Hepatic microsomal N-demethylation and glucuronidation as measured by radiometric assays. Pharmacology 18:241-250.
10. Dvorchik BH, Woodward G, Sitar DS, and Tweed WA (1986) Hydroxylation and glucuronidation of various xenobiotics by hepatic microsomes from the fetal lamb, pregnant ewe and human fetus. Dev Pharmacol Ther 9:282-289.
11. Fletcher AJ, Goodfellow MR, Forhead AJ, Gardner DS, McGarrigle HH, Fowden AL, and Giussani DA (2000) Low doses of dexamethasone suppress pituitary-adrenal function but augment the glycemic response to acute hypoxemia in fetal sheep during late gestation. Pediatr Res 47:684-691.
12. Fox H (1995) Placental structure, in Scientific Basis of Obstetrics and Gynaecology (Macdonald RR ed), pp 1-28, Churchill Livingstone, Edinburgh.
13. Galan HL, Jozwik M, Rigano S, Regnault TR, Hobbins JC, Battaglia FC, and Ferrazzi E (1999) Umbilical vein blood flow determination in the ovine fetus: comparison of Doppler ultrasonographic and steady-state diffusion techniques. Am J Obstet Gynecol 181:1149-1153.
14. Garland M (1998) Pharmacology of drug transfer across the placenta. Obstet Gynecol Clin North Am 25:21-42.
15. Garland M, Abildskov KM, Altincatal A, and Stark RI (2005) (2005a) Models of morphine disposition in the fetal baboon. Pediatric Academic Societies PAS 57:1944.
16. Garland M, Abildskov KM, Kiu TW, Daniel SS, and Stark RI (2005b) The contribution of fetal metabolism to the disposition of morphine. Drug Metab Dispos 33:68-76.
17. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1996) Zidovudine kinetics in the pregnant baboon. J Acquir Immune Defic Syndr Hum Retrovirol 11:117-127.
18. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1998a) Implications of the kinetics of zidovudine in the pregnant baboon following oral administration. J Acquir Immune Defic Syndr Hum Retrovirol 19:433-440.
19. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM, and Stark RI (1998b) Placental transfer and fetal metabolism of zidovudine in the baboon. Pediatr Res 44:47-53.
20. Garland M, Szeto HH, and Stark RI (1998c) The primate placenta is permeable to glucuronide metabolites. Pediatr Res 43:59A.
21. Gerdin E, Gabrielsson J, Lindberg B, and Rane A (1990a) Disposition of morphine-3-glucuronide in the pregnant rhesus monkey. Pharmacol Toxicol 66:815-819.
22. Gerdin E, Salmonson T, Lindberg B, and Rane A (1990b) Maternal kinetics of morphine during labour. J Perinat Med 18:479-487.
23. Gibaldi M and Perrier D (1982) Pharmacokinetics. Marcel Dekker, Inc., New York.
24. Glover DD, Amonkar M, Rybeck BF, and Tracy TS (2003) Prescription, over-the-counter and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol 188:1039-1045.
25. Grieve PG, Myers MM, and Stark RI (1994) Behavioral states in the fetal baboon. Early Hum Dev 39:159-175.
26. Hartley R, Quinn M, Green M, and Levene MI (1993) Morphine glucuronidation in premature neonates. Br J Clin Pharmacol 35:314-317.
27. Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, and Moore DD (2003) Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci USA 100:4156-4161.
28. Krauer B, Dayer P, and Anner R (1984) Changes in serum albumin and alpha 1-acid glycoprotein concentrations during pregnancy: an analysis of fetal-maternal pairs. Br J Obstet Gynaecol 91:875-881.
29. Kumar S, Riggs KW, and Rurak DW (1999) Role of the liver and gut in systemic diphenhydramine clearance in adult nonpregnant sheep. Drug Metab Dispos 27:297-302.
30. Liggins GC and Howie RN (1972) A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50:515-525.
31. McRorie TI, Lynn AM, Nespeca MK, Opheim KE, and Slattery JT (1992) The maturation of morphine clearance and metabolism. Am J Dis Child 146:972-976.
32. Milne RW, Nation RL, and Somogyi AA (1996) The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals and the importance of the metabolites to the pharmacological effects of morphine. Drug Metab Rev 28:345-472.
33. Milne RW, Sloan PA, McLean CF, Mather LE, Nation RL, Runciman WB, Rutten AJ, and Somogyi AA (1993) Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep. Drug Metab Dispos 21:1151-1156.
34. Olsen GD, Sommer KM, Wheeler PL, Boyea SR, Michelson SP, and Cheek DB (1988) Accumulation and clearance of morphine-3-beta-D-glucuronide in fetal lambs. J Pharmacol Exp Ther 247:576-584.
35. Pacifici GM, Sawe J, Kager L, and Rane A (1982) Morphine glucuronidation in human fetal and adult liver. Eur J Clin Pharmacol 22:553-558.
36. Rane A, Sawe J, Lindberg B, Svensson JO, Garle M, Erwald R, and Jorulf H (1984) Morphine glucuronidation in the rhesus monkey: a comparative in vivo and in vitro study. J Pharmacol Exp Ther 229:571-576.
37. Ring JA, Ghabrial H, Ching MS, Smallwood RA, and Morgan DJ (1999) Fetal hepatic drug elimination. Pharmacol Ther 84:429-445.
38. Scott CS, Riggs KW, Ling EW, Fitzgerald CE, Hill ML, Grunau RV, Solimano A, and Craig KD (1999) Morphine pharmacokinetics and pain assessment in premature newborns. J Pediatr 135:423-429.
39. Simpson JM and Sharland GK (1998) Fetal tachycardias: management and outcome of 127 consecutive cases. Heart 79:576-581.
40. Stark RI, Daniel SS, James LS, MacCarter G, Morishima HO, Niemann WH, Rey H, Tropper PJ, and Yeh MN (1989) Chronic instrumentation and longterm investigation in the fetal and maternal baboon: tether system, conditioning procedures and surgical techniques. Lab Anim Sci 39:25-32.
41. Stark RI, Daniel SS, Kim YI, Leung K, Rey HR, and Tropper PJ (1993) Patterns of development in fetal breathing activity in the latter third of gestation of the baboon. Early Hum Dev 32:31-47.
42. Stark RI, Myers MM, Daniel SS, Garland M, and Kim YI (1999) Gestational age related changes in cardiac dynamics of the fetal baboon. Early Hum Dev 53:219-237.
43. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, and Sueyoshi T (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232-1238.
44. Szeto HH, Umans JG, and Rubinow SI (1982) The contribution of transplacental clearances and fetal clearance to drug disposition in the ovine maternal-fetal unit. Drug Metab Dispos 10:382-386.
45. Tocque B, Pontikis R, Nam NH, Hoellinger H, and Leroux Y (1980) Morphine and methadone binding to human serum proteins. J Pharm Pharmacol 32:729-731.
46. Townsend SF, Rudolph CD, and Rudolph AM (1989) Changes in ovine hepatic circulation and oxygen consumption at birth. Pediatr Res 25:300-304.
47. Tuntland T, Odinecs A, Nosbisch C, and Unadkat JD (1998) In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens. J Pharmacol Exp Ther 285:54-62.
48. Wang LH, Rudolph AM, and Benet LZ (1986a) Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. J Pharmacol Exp Ther 238:198-205.
49. Wang LH, Rudolph AM, and Benet LZ (1990) Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods. Dev Pharmacol Ther 14:161-179.
50. Wang LH, Zakim D, Rudolph AM, and Benet LZ (1986b) Developmental alterations in hepatic UDP-glucuronosyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs. Biochem Pharmacol 35:3065-3070.
51. Wu CY and Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res (NY) 22:11-23.
52. Young AM, Allen CE, and Audus KL (2003) Efflux transporters of the human placenta. Adv Drug Deliv Rev 55:125-132.