Type-3 metabotropic glutamate receptors negatively modulate bone morphogenetic protein receptor signaling and support the tumourigenic potential of glioma-initiating cells

Neuropharmacology

Volumn 55, Issue 4, 2008, Pages 568-576

  Ciceroni, C ^a   Arcella, A ^b   Mosillo, P ^c   Battaglia, G ^b   Mastrantoni, E ^c   Oliva, M A ^b   Carpinelli, G ^d   Santoro, F ^d   Sale, P ^a,c   Ricci Vitiani, L ^d   De Maria, R ^d   Pallini, R ^e   Giangaspero, F ^b,c   Nicoletti, F ^b,c   Melchiorri, D ^a,c  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b IRCCS NEUROMED   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

Author keywords

Glioblastoma; Glioma initiating cells; Glutamate; mGlu3 receptor

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; BONE MORPHOGENETIC PROTEIN RECEPTOR; METABOTROPIC RECEPTOR 3; SMAD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; GLIOBLASTOMA; GLIOMA CELL; GLIOMA INITIATING CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR CELL; TUMOR GROWTH;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BONE MORPHOGENETIC PROTEIN RECEPTORS; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLIOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; PHOSPHORYLATION; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; XANTHENES;

EID: 49949108326     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.064     Document Type: Article

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