Family-based association studies of CAPON and schizophrenia in the Chinese Han population

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 5, 2008, Pages 1210-1213

  Fang, C ^a,b   Tang, W ^a,b   Tang, R Q ^a,b   Wang, L ^a,b   Zhou, G Q ^a,h   Huang, K ^a,b   Li, X W ^a,b   Feng, G Y ^c   He, M ⁱ   Du, L Z ⁱ   Zhu, S M ^e   Xing, Y L ^f   Sang, H ^g   He, L ^a,d   Shi, Y Y ^a,b,h  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c SHANGHAI MENTAL HEALTH CENTER   (China)

^d Institutes of Brain Science   (China)

^e Jilin Institute of Brain Research   (China)

^f Xi'an Institute of Mental Health   (China)

^g Changchun Kaixuan Hospital   (China)

^h Health Inspection Institute of Changning District   (China)

ⁱ SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

CAPON; Chinese population; Genetic association; Schizophrenia; SNP; Transmission Disequilibrium Test (TDT)

Indexed keywords

CARBOXY TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE; DNA; GLUTAMIC ACID; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CAPON GENE; CARBOXY TERMINAL SEQUENCE; CASE CONTROL STUDY; CHINESE; CHROMOSOME 1Q; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; ETHNIC GROUP; FAMILY STUDY; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROTRANSMISSION; PEDIGREE ANALYSIS; POPULATION GENETICS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 49849100200     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.03.007     Document Type: Article

References (20)

1. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 2 (2005) 263-265
2. Brzustowicz L.M., Simone J., Mohseni P., Hayter J.E., Hodgkinson K.A., Chow E.W., et al. Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22. Am J Hum Genet 74 (2004) 1057-1063
3. Cloninger C.R. The discovery of susceptibility genes for mental disorders. Proc Natl Acad Sci USA 99 (2002) 13365-13367
4. Ding Y.C., Wooding S., Harpending H.C., Chi H.C., Li H.P., Fu Y.X., et al. Population structure and history in East Asia. Proc Natl Acad Sci USA 97 (2000) 14003-14006
5. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 (2003) 115-121
6. Eastwood S.L. Does the CAPON gene confer susceptibility to schizophrenia?. PLoS Med 2 10 (2005) e348
7. Hashimoto R., Hattori S., Chiba S., Yagasaki Y., Okada T., Kumamaru E., et al. Susceptibility genes for schizophrenia. Psychiatry Clin Neurosci 60 Suppl 1 (2006) S4-S10
8. Hirschhorn J.N., and Daly M.J. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6 (2005) 95-108
9. Marchini J., Donnelly P., and Cardon L.R. Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 37 (2005) 413-417
10. Miranda A., García J., López C., Gordon D., Palacio C., Restrepo G., et al. Putative association of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase gene (CAPON) with schizophrenia in a Colombian population. Schizophr Res 82 2-3 (2006) 283-285
11. Norton N., Williams H.J., and Owen M.J. An update on the genetics of schizophrenia. Curr Opin Psychiatry 19 (2006) 158-164
12. O'Donovan M.C., Williams N.M., and Owen M.J. Recent advances in the genetics of schizophrenia. Hum Mol Genet 12 Spec No. 2 (2003) R125-R133
13. Purcell S., Cherny S.S., and Sham P.C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 1 (2003) 149-150
14. Puri V., McQuillin A., Thirumalai S., Lawrence J., Krasucki R., Choudhury K., et al. Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample. Biol Psychiatry 59 2 (2006) 195-197
15. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 46 (1990) 229-241
16. Schaid D.J. Transmission disequilibrium, family controls, and great expectations. Am J Hum Genet 63 (1998) 935-941
17. Shi Y.Y., and He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15 2 (2005) 97-98
18. Shi Y., Zhao X., Yu L., Tao R., Tang J., La Y., et al. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome Res 14 (2004) 1345-1349
19. Xu B., Wratten N., Charych E.I., Buyske S., Firestein B.L., and Brzustowicz L.M. Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. PLoS Med 2 10 (2005) e263
20. Zheng Y., Li H., Qin W., Chen W., Duan Y., Yue Xiao, et al. Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochem Biophys Res Commun 328 (2005) 809-815