Imbalance of RANK, RANKL and OPG expression during tibial fracture repair in diabetic rats

Journal of Molecular Histology

Volumn 39, Issue 4, 2008, Pages 401-408

  De Amorim, Fernanda Penna Lima Guedes ^a   Ornelas, Sócrates Souza ^a   Diniz, Sandoval Felicíssimo ^a   Batista, Aline Carvalho ^b   Da Silva, Tarcília Aparecida ^c  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Diabetes; Facture repair; OPG; RANK; RANKL

Indexed keywords

ALLOXAN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CONTROLLED STUDY; DIABETES MELLITUS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIBIA FRACTURE;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; OSTEOPROTEGERIN; RANK LIGAND; RATS; RATS, WISTAR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; TIBIAL FRACTURES;

RATTUS;

EID: 49849083026     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-008-9178-x     Document Type: Article

References (33)

1. An YH, Friedman RJ (1999) Animal models in orthopedic research. CRC Press, Boca Raton
2. WJ Boyle WS Simonet DL Lacey 2003 Osteoclast differentiation and activation Nature 423 337 342 10.1038/nature01658
3. Dib SA, Russo EMK, Chacra AR (1992) Tratado de endocrinologia clínica. Ed. Rocca, São Paulo
4. SF Diniz FP Amorim FF Cavalcante-Neto 2008 Alloxan-induced diabetes delays repair in a rat model of closed tibial fracture Braz J Med Biol Res 41 373 379
5. PM Duarte JB Neto MZ Casati 2007 Diabetes modulates gene expression in the gingival tissues of patients with chronic periodontitis Oral Dis 13 594 599 10.1111/j.1601-0825.2006.01348.x
6. N Follak I Kloting D Ganzer 2003 Scanning electron microscopic examinations on retarded bone defect healing in spontaneously diabetic BB/O(ttawa)K(arlsburg) rats Histol Histopathol 18 111 120
7. N Follak I Kloting E Wolf 2004 Histomorphometric evaluation of the influence of the diabetic metabolic state on bone defect healing depending on the defect size in spontaneously diabetic BB/OK rats Bone 35 144 152 10.1016/j.bone.2004.03.011
8. N Follak L Kloting E Wolf 2004 Delayed remodeling in the early period of fracture healing in spontaneously diabetic BB/OK rats depending on the diabetic metabolic state Histol Histopathol 19 473 486
9. N Follak I Kloting H Merk 2005 Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats Diabetes Metab Res Rev 21 288 296 10.1002/dmrr.537
10. JR Funk JE Hale D Carmines 2000 Biomechanical evaluation of early fracture healing in normal and diabetic rats J Orthop Res 18 126 132 10.1002/jor.1100180118
11. F Galluzzi S Stagi R Salti 2005 Osteoprotegerin serum levels in children with type 1 diabetes: a potential modulating role in bone status Eur J Endocrinol 153 879 885 10.1530/eje.1.02052
12. HL Gooch JE Hale H Fujioka 2000 Alterations of cartilage and collagen expression during fracture healing in experimental diabetes Connect Tissue Res 41 81 91 10.3109/03008200009067660
13. MP Guarneri G Weber P Gallia 1993 Effect of insulin treatment on osteocalcin levels in diabetic children and adolescents J Endocrinol Invest 16 505 509
14. H He R Liu T Desta C Leone 2004 Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss Endocrinology 145 447 452 10.1210/en.2003-1239
15. S Herrero OM Calvo C García-Moreno 1998 Low bone density with normal bone turnover in ovariectomized and streptozotocin-induced diabetic rats Calcif Tissue Int 62 260 265 10.1007/s002239900427
16. M Hie M Shimono K Fujii 2007 Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats Bone 41 1045 1050
17. MN Horcajada-Molteni B Chanteranne P Lebecque 2001 Amylin and bone metabolism in streptozotocin-induced diabetic rats J Bone Miner Res 16 958 965 10.1359/jbmr.2001.16.5.958
18. K Katsumata K Katsumata Jr Y Katsumata 1992 Protective effect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats Horm Metab Res 24 508 510
19. RA Kayal D Tsatsas MA Bauer 2007 Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity J Bone Miner Res 22 560 568 10.1359/jbmr.070115
20. M Kobayashi-Sakamoto K Hirose M Nishikata 2006 Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases FEMS Microbiol Lett 264 238 245 10.1111/j.1574-6968.2006.00458.x
21. JC Krakauer MJ McKenna NF Buderer 1995 Bone loss and bone turnover in diabetes Diabetes 44 775 782 10.2337/diabetes.44.7.775
22. DL Lacey E Timms HL Tan 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 165 176 10.1016/S0092-8674(00)81569-X
23. ME Levin VC Boisseau LV Avioli 1976 Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes N Engl J Med 294 241 245
24. LR Macey SM Kana S Jingushi 1989 Defects of early fracture-healing in experimental diabetes J Bone Joint Surg Am 71 722 733
25. T Miazgowski S Czekalski 1998 A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus Osteoporos Int 8 399 403 10.1007/s001980050082
26. JM Olmos JL Perez-Castrillon MT Garcia 1994 Bone densitometry and biochemical bone remodeling markers in type 1 diabetes mellitus Bone Miner 26 1 8
27. G Silvestrini P Ballanti F Patacchioli 2005 Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat J Mol Histol 36 59 67 10.1007/s10735-004-3839-1
28. T So SW Lee M Croft 2006 Tumour necrosis factor/tumour necrosis factor receptor family members that positively regulate immunity Int J Hematol 83 1 11 10.1532/IJH97.05120
29. K Suzuki T Kurose M Takizawa 2005 Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density Diabetes Res Clin Pract 68 117 125 10.1016/j.diabres. 2004.08.006
30. T Szkudelski 2001 The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Physiol Res 50 537 546
31. JT Tuominen O Impivaara P Puukka 1999 Bone mineral density in patients with type 1 and type 2 diabetes Diabetes Care 22 1196 1200 10.2337/diacare.22.7. 1196
32. C Wetzler H Kampfer B Stallmeyer 2000 Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair J Invest Dermatol 115 245 253 10.1046/j.1523-1747.2000.00029.x
33. H Yasuda N Shima N Nakagawa 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Proc Natl Acad Sci USA 95 3597 3602 10.1073/pnas.95.7.3597