Polymerization-defective fibrinogen variant γD364A binds knob "A" peptide mimic

Biochemistry

Volumn 47, Issue 33, 2008, Pages 8607-8613

  Bowley, Sheryl R ^a   Merenbloom, Betsy K ^b,f   Okumura, Nobuo ^c   Betts, Laurie ^b   Heroux, Annie ^d   Gorkun, Oleg V ^b   Lord, Susan T ^a,b,e  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SHINSHU UNIVERSITY   (Japan)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f BIOMÉRIEUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; CRYSTALLOGRAPHIC STUDIES; ELECTROSTATIC INTERACTIONS; GLOBAL STRUCTURES; MOLECULAR BASES; NEGATIVE CHARGING; NEGATIVE ELECTROSTATIC POTENTIALS; PROTECTION ASSAYS;

AMINES; CALCIUM; CHEMICAL REACTIONS; ELECTRIC BREAKDOWN; ELECTROSTATICS; FLOW INTERACTIONS; KNOBS; MONOMERS; POLYMERIZATION; POLYMERS;

CRYSTAL STRUCTURE;

ASPARTIC ACID; CALCIUM; FIBRINOGEN; GLYCYLPROLYLARGINYLPROLINE; PEPTIDE; PLASMIN;

ARTICLE; CRYSTAL STRUCTURE; ELECTRICITY; FIBRIN POLYMERIZATION; MOLECULAR MIMICRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; SUBSTITUTION REACTION;

ELECTROSTATICS; FIBRINOGENS, ABNORMAL; MODELS, MOLECULAR; OLIGOPEPTIDES; POLYMERS; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 49749122629     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8000769     Document Type: Article

References (34)

1. Weisel, J. W. (2005) Fibrinogen and fibrin. Adv. Protein Chem. 70, 247-299.
2. Litvinov, R. I., Yakovlev, S., Tsurupa, G., Gorkun, O. V., Medved, L., and Weisel, J. W. (2007) Direct evidence for specific interactions of the fibrinogen alphaC-domains with the central E region and with each other. Biochemistry 46, 9133-9142.
3. Doolittle, R. F. (1984) Fibrinogen and fibrin. Annu. Rev. Biochem. 53, 195-229.
4. Olexa, S. A., and Budzynski, A. Z. (1980) Evidence for four different polymerization sites involved in human fibrin formation. Proc. Natl. Acad. Sci. U.S.A. 77, 1374-1378.
5. Fowler, W. E., Hantgan, R. R., Hermans, J., and Erickson, H. P. (1981) Structure of the fibrin protofibril. Proc. Natl. Acad. Sci. U.S.A. 78, 4872-4876.
6. Blomback, B., Hessel, B., Hogg, D., and Therkildsen, L. (1978) A two-step fibrinogen-fibrin transition in blood coagulation. Nature 275, 501-505.
7. Weisel, J. W., Veklich, Y., and Gorkun, O. (1993) The sequence of cleavage of fibrinopeptides from fibrinogen is important for protofibril formation and enhancement of lateral aggregation in fibrin clots. J. Mol. Biol. 232, 285-297.
8. Spraggon, G., Everse, S. J., and Doolittle, R. F. (1997) Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. Nature 389, 455-462.
9. Kostelansky, M. S., Betts, L., Gorkun, O. V., and Lord, S. T. (2002) 2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site. Biochemistry 41, 12124-12132.
10. Okumura, N., Furihata, K., Terasawa, F., Nakagoshi, R., Ueno, I., and Katsuyama, T. (1996) Fibrinogen Matsumoto I: a gamma 364 Asp→His (GAT→CAT) substitution associated with defective fibrin polymerization. Thromb. Haemostasis 75, 887-891.
11. Bentolila, S., Samama, M. M., Conard, J., Horellou, M. H., and French, P. (1995) Association of dysfibrinogenemia and thrombosis. Apropos of a family (Fibrinogen Melun) and review of the literature. Ann. Med. Interne (Paris) 146, 575-580.
12. Okumura, N., Terasawa, F., Haneishi, A., Fujihara, N., Hirota-Kawadobora, M., Yamauchi, K., Ota, H., and Lord, S. T. (2007) B:b interactions are essential for polymerization of variant fibrinogens with impaired holes "a", J. Thromb. Haemostasis.
13. Okumura, N., Gorkun, O. V., and Lord, S. T. (1997) Severely impaired polymerization of recombinant fibrinogen gamma-364 Asp→His, the substitution discovered in a heterozygous individual. J. Biol. Chem. 272, 29596-29601.
14. Lord, S. T., Strickland, E., and Jayjock, E. (1996) Strategy for recombinant multichain protein synthesis: fibrinogen B beta-chain variants as thrombin substrates. Biochemistry 35, 2342-2348.
15. Lord, S. T., Binnie, C. G., Hettasch, J. M., and Strickland, E. (1993) Purification and characterization of recombinant human fibrinogen. Blood Coagulation Fibrinolysis 4, 55-59.
16. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
17. Kostelansky, M. S., Lounes, K. C., Ping, L. F., Dickerson, S. K., Gorkun, O. V., and Lord, S. T. (2007) Probing the gamma2 calcium-binding site: Studies with gammaD298,301A fibrinogen reveal changes in the gamma294-301 loop that alter the integrity of the "a" polymerization site. Biochemistry 46, 5114-5123.
18. Solis, D., Arias, M., Tercero, J. C., and Diaz-Maurino, T. (1989) Fractionation of plasmic fibrin(ogen) digests by lectin affinity chromatography. Thromb. Res. 55, 221-232.
19. Everse, S. J., Pelletier, H., and Doolittle, R. F. (1995) Crystallization of fragment D from human fibrinogen. Protein Sci. 4, 1013-1016.
20. Otwinowski, Z., and Minor, W. (1997) Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326.
21. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921.
22. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119.
23. Read, R. J. (1986) Improved Fourier coefficients for maps using phases from partial structures with errors. Acta Crystallogr. A 42, 140-149.
24. Pratt, K. P., Cote, H. C., Chung, D. W., Stenkamp, R. E., and Davie, E. W. (1997) The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Proc. Natl. Acad. Sci. U.S.A. 94, 7176-7181.
25. Kostelansky, M. S., Bolliger-Stucki, B., Betts, L., Gorkun, O. V., and Lord, S. T. (2004) B beta Glu397 and B beta Asp398 but not B beta Asp432 are required for "B:b" interactions. Biochemistry 43, 2465-2474.
26. Kostelansky, M. S., Lounes, K. C., Ping, L. F., Dickerson, S. K., Gorkun, O. V., and Lord, S. T. (2004) Calcium-binding site beta 2, adjacent to the "b" polymerization site, modulates lateral aggregation of protofibrils during fibrin polymerization. Biochemistry 43, 2475-2483.
27. Jabs, A., Weiss, M. S., and Hilgenfeld, R. (1999) Non-proline cis peptide bonds in proteins. J. Mol. Biol. 286, 291-304.
28. Doolittle, R. F., Chen, A., and Pandi, L. (2006) Differences in binding specificity for the homologous gamma- and beta-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the beta-chain hole. Biochemistry 45, 13962-13969.
29. Burley, S. K., and Petsko, G. A. (1986) Amino-aromatic interactions in proteins. FEBS Lett. 203, 139-143.
30. Yee, V. C., Pratt, K. P., Cote, H. C., Trong, I. L., Chung, D. W., Davie, E. W., Stenkamp, R. E., and Teller, D. C. (1997) Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen. Structure 5, 125-138.
31. Lounes, K. C., Ping, L., Gorkun, O. V., and Lord, S. T. (2002) Analysis of engineered fibrinogen variants suggests that an additional site mediates platelet aggregation and that "B-b" interactions have a role in protofibril formation. Biochemistry 41, 5291-5299.
32. Kostelansky, M. S., Lounes, K. C., Ping, L. F., Dickerson, S. K., Gorkun, O. V., and Lord, S. T. (2007) Probing the gamma2 calcium-binding site: studies with gammaD298,301A fibrinogen reveal changes in the gamma294-301 loop that alter the integrity of the "a" polymerization site. Biochemistry 46, 5114-5123.
33. Gorkun, O. V., Litvinov, R. I., Veklich, Y. I., and Weisel, J. W. (2006) Interactions mediated by the N-terminus of fibrinogen's Bbeta chain. Biochemistry 45, 14843-14852.
34. Doolittle, R. F. (1981) Fibrinogen and fibrin. Sci. Am. 245, 126-135.