Probing the γ2 calcium-binding site: Studies with γD298,301A fibrinogen reveal changes in the γ294-301 loop that alter the integrity of the "a" polymerization site

Biochemistry

Volumn 46, Issue 17, 2007, Pages 5114-5123

  Kostelansky, Michael S ^a   Lounes, Karim C ^b,c   Ping, Li Fang ^b   Dickerson, Sarah K ^b   Gorkun, Oleg V ^b   Lord, Susan T ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Biolex Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM-BINDING SITES; FIBRINOGEN; LOCAL CONFORMATIONAL CHANGES; PLASMINS;

AMINO ACIDS; CALCIUM; CATALYSIS; CONFORMATIONS; LIGANDS; POLYMERIZATION; PROTEOLYSIS; SYNTHESIS (CHEMICAL);

PROTEINS;

ALANINE; BATROXOBIN; CALCIUM; FIBRIN; FIBRINOGEN; GLYCYLHISTIDYLARGINYLPROLINAMIDE; GLYCYLPROLYLARGINYLPROLINAMIDE; LIGAND; PEPTIDE DERIVATIVE; PLASMIN; UNCLASSIFIED DRUG; BIOPOLYMER; PRIMER DNA; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; CHEMISTRY; CRYSTALLIZATION; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR PROBE; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; BIOPOLYMERS; CALCIUM; CRYSTALLIZATION; DNA PRIMERS; FIBRINOGEN; MOLECULAR PROBES; MUTAGENESIS, SITE-DIRECTED; PLASMIN; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 34247594833     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi602607a     Document Type: Article

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