Clomipramine block of the hERG K+ channel: Accessibility to F656 and Y652

European Journal of Pharmacology

Volumn 592, Issue 1-3, 2008, Pages 19-25

  Jo, Su Hyun ^a   Hong, Hee Kyung ^a   Chong, Seon Ha ^b   Won, Kwang Hee ^b   Jung, Sung Jun ^a   Choe, Han ^b  

^a Kangwon National University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Arrhythmia; Clomipramine; hERG channel; LQT; Rapidly activating delayed rectifier K+ current; Torsades de pointes; Tricyclic antidepressant

Indexed keywords

CLOMIPRAMINE; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENE MUTATION; HEART PROARRHYTHMIA; HUMAN; HUMAN CELL; IC 50; LONG QT SYNDROME; MEMBRANE POTENTIAL; MICROELECTRODE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; STEADY STATE; VOLTAGE CLAMP; XENOPUS;

ALGORITHMS; ANIMALS; CELLS, CULTURED; CLOMIPRAMINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LONG QT SYNDROME; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; POINT MUTATION; POTASSIUM CHANNEL BLOCKERS; SEROTONIN UPTAKE INHIBITORS; XENOPUS LAEVIS;

EID: 49749118282     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.094     Document Type: Article

References (31)

1. Baldessarini R.J. Drugs and the treatment of psychiatric disorders. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). Goodman and Gilman's the Pharmacological Basis of Therapeutics (2001), McGraw-Hill, NY 447-483
2. Bonin B., Bertschy G., Baumann P., Francois T., Vandel P., Vandel S., Sechter D., and Bizouard P. Fluoxetine and tricyclic antidepressants: clinical tolerance in short-term combined administration. Encephale 22 (1996) 221-227
3. Kr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. J. Pharmacol. Exp. Ther. 313 (2005) 888-895
4. Flugelman M.Y., Pollack S., Hammerman H., Riss E., and Barzilai D. Congenital prolongation of Q-T interval: a family study of three generations. Cardiology 69 (1982) 170-174
5. Frommer D.A., Kulig K.W., Marx J.A., and Rumack B. Tricyclic antidepressant overdose. JAMA 257 (1987) 521-526
6. Glassmann A.H. Clinical Management of cardiovascular risks during treatment with psychotropic drugs. J. Clin. Psychiatry 63 (2002) 12-17
7. Halper J.P., and Mann J.J. Cardiovascular effects of antidepressant medications. Br. J. Psychiatr., Suppl. (1988) 87-98 Sep
8. Hannerz H., and Borga P. Mortality among persons with a history as psychiatric inpatients with functional psychosis. Soc. Psychiatry Psychiatr. Epidemiol. 35 (2000) 380-387
9. Haverkamp W., Breithardt G., Camm A.J., Janse M.J., Rosen M.R., Antzelevitch C., Escande D., Franz M., Malik M., Moss A., and Shah R. The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. Cardiovasc. Res. 47 (2000) 219-233
10. Hondeghem L.M., and Hoffmann P. Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability. J. Cardiovasc. Pharmacol. 41 (2003) 14-24
11. Kiehn J., Thomas D., Karle C.A., Schols W., and Kubler W. Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn-Schmiedeberg's Arch. Pharmacol. 359 (1999) 212-219
12. + channels by various antidepressant drugs. Neuropsychopharmacology 29 (2004) 1841-1851
13. Kr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine. Br. J. Pharmacol. 148 (2006) 499-509
14. Leonard H.L., Meyer M.C., Swedo S.E., Richter D., Hamburger S.D., Allen A.J., Rapoport J.L., and Tucker E. Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents. J. Am. Acad. Child Adolesc. Psychiatry 34 (1995) 1460-1468
15. Marshall J.B., and Forker A.D. Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications. Am. Heart J. 103 (1982) 401-414
16. Mitcheson J.S. Drug binding to HERG channels: evidence for a "non-aromatic" binding site for fluvoxamine. Br. J. Pharmacol. 139 (2003) 883-884
17. Mitcheson J.S., Chen J., Lin M., Culberson C., and Sanguinetti M.C. A structural basis for drug-induced long QT syndrome. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 12329-12333
18. Petit J.M., Spiker D.G., Ruwitch J.F., Ziegler V.E., Weiss A.N., and Biggs J.T. Tricyclic antidepressant plasma levels and adverse effects after overdose. Clin. Pharmacol. Ther. 21 (1977) 47-51
19. Rampe D., Roy M.L., Dennis A., and Brown A.M. A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett. 417 (1997) 28-32
20. Redfern W.S., Carlsson L., Davis A.S., Lynch W.G., MacKenzie I., Palethorpe S., Siegl P.K., Strang I., Sullivan A.T., Wallis R., Camm A.J., and Hammond T.G. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58 (2003) 32-45
21. Rodriguez de la Torre B., Dreher J., Malevany I., Bagli M., Kolbinger M., Omran H., Lüderitz B., and Rao M.L. Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients. Ther. Drug Monit. 23 (1972) 435-440
22. + channel block. J. Biol. Chem. 277 (2002) 23587-23595
23. Snyders J., Knoth K.M., Roberds S.L., and Tamkun M.M. Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel. Mol. Pharmacol. 41 (1992) 322-330
24. Suessbrich H., Waldegger S., Lang F., and Busch A.E. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett. 385 (1996) 77-80
25. Tie H., Walker B.D., Valenzuela S.M., Breit S.N., and Campbell T.J. The heart of psychotropic drug therapy. Lancet 355 (2000) 1825
26. Toro P., Nores J.M., and Remy J.M. Clomipramine dependence in a drug addict. 1st case. Presse Med. 18 (1989) 132
27. Trimble M.R. Worldwide use of clomipramine. J. Clin. Psychiatry 51 Suppl:51-4 (1990) discussion 55-58
28. Warrington S.J., Padgham C., and Lader M. The cardiovascular effects of antidepressants. Psychol. Med. Monogr. Suppl. 16 (1989) 1-40
29. Witchel H.J., Hancox J.C., and Nutt D.J. Psychotropic drugs, cardiac arrhythmia, and sudden death. J. Clin. Psychopharmacol. 23 (2003) 58-77
30. Zhou Z., Gong Q., Ye B., Fan Z., Makielski J.C., Robertson G.A., and January C.T. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys. J. 74 (1998) 230-241
31. Zahradnik I., Minarovic I., and Zahradnikova A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J. Pharmacol. Exp. Ther. 324 (2007) 977-984