메뉴 건너뛰기




Volumn 3, Issue 3, 2008, Pages 135-147

Advanced non-small cell lung cancer therapy: Historical and future perspectives

Author keywords

Chemotherapy; Non small cell lung cancer (NSCLC); Radiotherapy; Survival; Targeted therapies

Indexed keywords


EID: 49749091665     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-008-0082-9     Document Type: Review
Times cited : (3)

References (89)
  • 2
    • 0026440636 scopus 로고
    • Chemotherapy of lung cancer
    • DC Ihde 1992 Chemotherapy of lung cancer N Engl J Med 327 1434 1441
    • (1992) N Engl J Med , vol.327 , pp. 1434-1441
    • Ihde, D.C.1
  • 4
    • 0025030719 scopus 로고
    • Chemotherapy for unresectable non-small cell lung cancer
    • DH Johnson 1990 Chemotherapy for unresectable non-small cell lung cancer Semin Oncol 17 20 29
    • (1990) Semin Oncol , vol.17 , pp. 20-29
    • Johnson, D.H.1
  • 5
    • 0022646219 scopus 로고
    • Long-term survivors in metastatic non-small cell lung cancer: An Eastern Cooperative Oncology Group study
    • DM Finkelstein DS Ettinger JC Ruckdeschel 1986 Long-term survivors in metastatic non-small cell lung cancer: an Eastern Cooperative Oncology Group study J Clin Oncol 4 702 709
    • (1986) J Clin Oncol , vol.4 , pp. 702-709
    • Finkelstein, D.M.1    Ettinger, D.S.2    Ruckdeschel, J.C.3
  • 6
    • 0033996533 scopus 로고    scopus 로고
    • Evolution of cisplatin-based chemotherapy in non-small cell lung cancer: A historical perspective and the Eastern Cooperative Oncology Group experience
    • DH Johnson 2000 Evolution of cisplatin-based chemotherapy in non-small cell lung cancer: a historical perspective and the Eastern Cooperative Oncology Group experience Chest 117 133 137
    • (2000) Chest , vol.117 , pp. 133-137
    • Johnson, D.H.1
  • 7
    • 0014274960 scopus 로고
    • The survival of patients with inoperable lung cancer: A large-scale randomized study of radiation therapy versus placebo
    • B Roswit ME Patno R Rapp 1968 The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo Radiology 90 688 697
    • (1968) Radiology , vol.90 , pp. 688-697
    • Roswit, B.1    Patno, M.E.2    Rapp, R.3
  • 8
    • 0025307174 scopus 로고
    • Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer
    • DH Johnson LH Einhorn A Bartolucci 1990 Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer Ann Intern Med 113 33 38
    • (1990) Ann Intern Med , vol.113 , pp. 33-38
    • Johnson, D.H.1    Einhorn, L.H.2    Bartolucci, A.3
  • 9
    • 0025817202 scopus 로고
    • Recent outcomes for patients with carcinoma of the lung
    • RO Dillman C Berry KP Ryan 1991 Recent outcomes for patients with carcinoma of the lung Cancer Invest 9 9 17
    • (1991) Cancer Invest , vol.9 , pp. 9-17
    • Dillman, R.O.1    Berry, C.2    Ryan, K.P.3
  • 10
    • 0023840994 scopus 로고
    • Non-small-cell lung cancer: Should unresectable stage III patients routinely receive high-dose radiation therapy
    • DG Payne 1988 Non-small-cell lung cancer: should unresectable stage III patients routinely receive high-dose radiation therapy J Clin Oncol 6 552 558
    • (1988) J Clin Oncol , vol.6 , pp. 552-558
    • Payne, D.G.1
  • 11
    • 0029083342 scopus 로고
    • Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages IIIa and IIIb non-small cell lung cancer
    • P Marino A Preatoni A Cantoni 1995 Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages IIIa and IIIb non-small cell lung cancer A meta-analysis. Cancer 76 593 601
    • (1995) A Meta-analysis. Cancer , vol.76 , pp. 593-601
    • Marino, P.1    Preatoni, A.2    Cantoni, A.3
  • 12
    • 0029778934 scopus 로고    scopus 로고
    • Improved survival in stage III non-small-cell lung cancer: 7-year follow-up of cancer and leukemia group B (CALGB) 8433 trial
    • RO Dillman J Herndon SL Seagren 1996 Improved survival in stage III non-small-cell lung cancer: 7-year follow-up of cancer and leukemia group B (CALGB) 8433 trial J Natl Cancer Inst 88 1210 1215
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1210-1215
    • Dillman, R.O.1    Herndon, J.2    Seagren, S.L.3
  • 13
    • 0028909219 scopus 로고
    • Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: Preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer
    • WT Sause C Scott S Taylor 1995 Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer J Natl Cancer Inst 87 198 205
    • (1995) J Natl Cancer Inst , vol.87 , pp. 198-205
    • Sause, W.T.1    Scott, C.2    Taylor, S.3
  • 14
    • 0026580034 scopus 로고
    • Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer
    • C Schaake-Koning BW van den O Dalesio 1992 Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer N Engl J Med 326 524 530
    • (1992) N Engl J Med , vol.326 , pp. 524-530
    • Schaake-Koning, C.1    Van Den, B.W.2    Dalesio, O.3
  • 15
    • 0029865811 scopus 로고    scopus 로고
    • Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: A randomized study
    • B Jeremic Y Shibamoto L Acimovic 1996 Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study J Clin Oncol 14 1065 1070
    • (1996) J Clin Oncol , vol.14 , pp. 1065-1070
    • Jeremic, B.1    Shibamoto, Y.2    Acimovic, L.3
  • 16
    • 0032858243 scopus 로고    scopus 로고
    • Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer
    • K Furuse M Fukuoka M Kawahara 1999 Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer J Clin Oncol 17 2692 2699
    • (1999) J Clin Oncol , vol.17 , pp. 2692-2699
    • Furuse, K.1    Fukuoka, M.2    Kawahara, M.3
  • 17
    • 4444293137 scopus 로고    scopus 로고
    • Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: A randomized study
    • P Zatloukal L Petruzelka M Zemanova 2004 Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study Lung Cancer 46 87 98
    • (2004) Lung Cancer , vol.46 , pp. 87-98
    • Zatloukal, P.1    Petruzelka, L.2    Zemanova, M.3
  • 18
    • 0346236869 scopus 로고    scopus 로고
    • Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemoradiation for patients with unresected stage III NSCLC: RTOG 9410
    • WJ Curran CB Scott CJ Langer 2003 Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemoradiation for patients with unresected stage III NSCLC: RTOG 9410 Proc Am Soc Clin Oncol 22 2499
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 2499
    • Curran, W.J.1    Scott, C.B.2    Langer, C.J.3
  • 19
    • 0028843552 scopus 로고
    • Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
    • Non-small Cell Lung Cancer Collaborative Group
    • Non-small Cell Lung Cancer Collaborative Group 1995 Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials BMJ 311 899 909
    • (1995) BMJ , vol.311 , pp. 899-909
  • 20
    • 0346560025 scopus 로고    scopus 로고
    • Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975
    • EF Smit JP van Meerbeeck P Lianes 2003 Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975 J Clin Oncol 21 3909 3917
    • (2003) J Clin Oncol , vol.21 , pp. 3909-3917
    • Smit, E.F.1    Van Meerbeeck, J.P.2    Lianes, P.3
  • 21
    • 0041912766 scopus 로고    scopus 로고
    • Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer: A phase III trial of the Italian GEMVIN Investigators and the National Cancer Institute of Canada Clinical Trials Group
    • C Gridelli C Gallo FA Shepherd 2003 Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer: a phase III trial of the Italian GEMVIN Investigators and the National Cancer Institute of Canada Clinical Trials Group J Clin Oncol 21 3025 3034
    • (2003) J Clin Oncol , vol.21 , pp. 3025-3034
    • Gridelli, C.1    Gallo, C.2    Shepherd, F.A.3
  • 22
    • 0036810227 scopus 로고    scopus 로고
    • Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: A cooperative multinational trial
    • R Rosell U Gatzemeier DC Betticher 2002 Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: a cooperative multinational trial Ann Oncol 13 1539 1549
    • (2002) Ann Oncol , vol.13 , pp. 1539-1549
    • Rosell, R.1    Gatzemeier, U.2    Betticher, D.C.3
  • 23
    • 0036731698 scopus 로고    scopus 로고
    • Treatment of advanced non-small-cell lung cancer with two-drug combinations
    • PA Bunn Jr. 2002 Treatment of advanced non-small-cell lung cancer with two-drug combinations J Clin Oncol 20 3565 3567
    • (2002) J Clin Oncol , vol.20 , pp. 3565-3567
    • Bunn Jr., P.A.1
  • 24
    • 0035397994 scopus 로고    scopus 로고
    • Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: A Southwest Oncology Group trial
    • K Kelly J Crowley PA Bunn Jr. 2001 Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial J Clin Oncol 19 3210 3218
    • (2001) J Clin Oncol , vol.19 , pp. 3210-3218
    • Kelly, K.1    Crowley, J.2    Bunn Jr., P.A.3
  • 25
    • 0036843105 scopus 로고    scopus 로고
    • Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer
    • GV Scagliotti MF De M Rinaldi 2002 Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer J Clin Oncol 20 4285 4291
    • (2002) J Clin Oncol , vol.20 , pp. 4285-4291
    • Scagliotti, G.V.1    De, M.F.2    Rinaldi, M.3
  • 26
    • 33847295600 scopus 로고    scopus 로고
    • Efficacy of the combination of cisplatin with either gemcitabine and vinorelbine or gemcitabine and paclitaxel in the treatment of locally advanced or metastatic non-small-cell lung cancer: A phase III randomised trial of the Southern Italy Cooperative Oncology Group (SICOG 0101)
    • P Comella G Filippelli CG De 2007 Efficacy of the combination of cisplatin with either gemcitabine and vinorelbine or gemcitabine and paclitaxel in the treatment of locally advanced or metastatic non-small-cell lung cancer: a phase III randomised trial of the Southern Italy Cooperative Oncology Group (SICOG 0101) Ann Oncol 18 324 330
    • (2007) Ann Oncol , vol.18 , pp. 324-330
    • Comella, P.1    Filippelli, G.2    De, C.G.3
  • 27
    • 1342268525 scopus 로고    scopus 로고
    • American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
    • DG Pfister DH Johnson CG Azzoli 2004 American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003 J Clin Oncol 22 330 353
    • (2004) J Clin Oncol , vol.22 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 28
    • 33144474858 scopus 로고    scopus 로고
    • Should chemotherapy combinations for advanced non-small cell lung cancer be platinum-based? a meta-analysis of phase III randomized trials
    • JL Pujol F Barlesi JP Daures 2006 Should chemotherapy combinations for advanced non-small cell lung cancer be platinum-based? A meta-analysis of phase III randomized trials Lung Cancer 51 335 345
    • (2006) Lung Cancer , vol.51 , pp. 335-345
    • Pujol, J.L.1    Barlesi, F.2    Daures, J.P.3
  • 29
    • 19444365516 scopus 로고    scopus 로고
    • Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: A meta-analysis of the published literature
    • G D'Addario M Pintilie NB Leighl 2005 Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature J Clin Oncol 23 2926 2936
    • (2005) J Clin Oncol , vol.23 , pp. 2926-2936
    • D'Addario, G.1    Pintilie, M.2    Leighl, N.B.3
  • 30
    • 33644841071 scopus 로고    scopus 로고
    • Adding gemcitabine to paclitaxel/carboplatin combination increases survival in advanced non-small-cell lung cancer: Results of a phase II-III study
    • A Paccagnella F Oniga A Bearz 2006 Adding gemcitabine to paclitaxel/carboplatin combination increases survival in advanced non-small-cell lung cancer: results of a phase II-III study J Clin Oncol 24 681 687
    • (2006) J Clin Oncol , vol.24 , pp. 681-687
    • Paccagnella, A.1    Oniga, F.2    Bearz, A.3
  • 31
    • 0030740432 scopus 로고    scopus 로고
    • Management strategies for recurrent non-small cell lung cancer
    • FV Fossella JS Lee WK Hong 1997 Management strategies for recurrent non-small cell lung cancer Semin Oncol 24 455 462
    • (1997) Semin Oncol , vol.24 , pp. 455-462
    • Fossella, F.V.1    Lee, J.S.2    Hong, W.K.3
  • 32
    • 1642575171 scopus 로고    scopus 로고
    • Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: Results of a prospective, randomized phase III trial
    • J Dancey FA Shepherd RJ Gralla 2004 Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial Lung Cancer 43 183 194
    • (2004) Lung Cancer , vol.43 , pp. 183-194
    • Dancey, J.1    Shepherd, F.A.2    Gralla, R.J.3
  • 33
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    • FA Shepherd J Dancey R Ramlau 2000 Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy J Clin Oncol 18 2095 2103
    • (2000) J Clin Oncol , vol.18 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 34
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • N Hanna FA Shepherd FV Fossella 2004 Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy J Clin Oncol 22 1589 1597
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 35
    • 31444448873 scopus 로고    scopus 로고
    • Optimizing first-line treatment options for patients with advanced NSCLC
    • Suppl. 3
    • H Wakelee CP Belani 2005 Optimizing first-line treatment options for patients with advanced NSCLC Oncologist 10 Suppl. 3 1 10
    • (2005) Oncologist , vol.10 , pp. 1-10
    • Wakelee, H.1    Belani, C.P.2
  • 36
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • JH Schiller D Harrington CP Belani 2002 Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer N Engl J Med 346 92 98
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 37
    • 3042538425 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer
    • AB Sandler DH Johnson RS Herbst 2004 Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer Clin Cancer Res 10 4258s 4262s
    • (2004) Clin Cancer Res , vol.10
    • Sandler, A.B.1    Johnson, D.H.2    Herbst, R.S.3
  • 38
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • G Bergers LE Benjamin 2003 Tumorigenesis and the angiogenic switch Nat Rev Cancer 3 401 410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 39
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • N Ferrara HP Gerber J LeCouter 2003 The biology of VEGF and its receptors Nat Med 9 669 676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 40
    • 0035865450 scopus 로고    scopus 로고
    • Clinical implications of circulating angiogenic factors in cancer patients
    • RTP Poon ST Fan J Wong 2001 Clinical implications of circulating angiogenic factors in cancer patients J Clin Oncol 19 1207 1225
    • (2001) J Clin Oncol , vol.19 , pp. 1207-1225
    • Poon, R.T.P.1    Fan, S.T.2    Wong, J.3
  • 41
    • 0037667420 scopus 로고    scopus 로고
    • Targeting HER1/EGFR: A molecular approach to cancer therapy
    • C Arteaga 2003 Targeting HER1/EGFR: a molecular approach to cancer therapy Semin Oncol 30 3 14
    • (2003) Semin Oncol , vol.30 , pp. 3-14
    • Arteaga, C.1
  • 43
    • 33744788613 scopus 로고    scopus 로고
    • Molecular biology of epidermal growth factor receptor inhibition for cancer therapy
    • S Oliveira PM van Bergen en Henegouwen G Storm 2006 Molecular biology of epidermal growth factor receptor inhibition for cancer therapy Expert Opin Biol Ther 6 605 617
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 605-617
    • Oliveira, S.1    Van Bergen En Henegouwen, P.M.2    Storm, G.3
  • 44
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • LG Presta H Chen SJ O'Connor 1997 Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders Cancer Res 57 4593 4599
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 45
    • 5644260822 scopus 로고    scopus 로고
    • Combination of Avastin and Xeloda synergistically inhibits colorectal tumor growth in a COLO205 tumor xenograft model
    • BQ Shen S Stainton D Li 2004 Combination of Avastin and Xeloda synergistically inhibits colorectal tumor growth in a COLO205 tumor xenograft model Proc Am Assoc Cancer Res 45 508
    • (2004) Proc Am Assoc Cancer Res , vol.45 , pp. 508
    • Shen, B.Q.1    Stainton, S.2    Li, D.3
  • 46
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • DH Johnson L Fehrenbacher WF Novotny 2004 Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer J Clin Oncol 22 2184 2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 47
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • A Sandler R Gray MC Perry 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2542 2550
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 49
    • 40849149751 scopus 로고    scopus 로고
    • Efficacy and safety results from BO17704, a randomised, placebo-controlled phase III study of bevacizumab in combination with cisplatin and gemcitabine in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC)
    • C Manegold J von Pawel P Zatloukal 2007 Efficacy and safety results from BO17704, a randomised, placebo-controlled phase III study of bevacizumab in combination with cisplatin and gemcitabine in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) European Journal of Cancer Supplements 5 357
    • (2007) European Journal of Cancer Supplements , vol.5 , pp. 357
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 50
    • 35548962413 scopus 로고    scopus 로고
    • Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704
    • June 20 Suppl.
    • C Manegold J von Pawel P Zatloukal 2007 Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704 J Clin Oncol 25 June 20 Suppl. 388s
    • (2007) J Clin Oncol , vol.25
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 51
    • 49749108607 scopus 로고    scopus 로고
    • BO17704: A phase III study of first-line cisplatin and gemcitabine with bevacizumab or placebo in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC)
    • Suppl. 4
    • M Reck J von Pawel P Zatloukal 2007 BO17704: a phase III study of first-line cisplatin and gemcitabine with bevacizumab or placebo in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) J Thor Oncol 2 Suppl. 4 S360
    • (2007) J Thor Oncol , vol.2 , pp. 360
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 52
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
    • F Ciardiello R Bianco V Damiano 1999 Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225 Clin Cancer Res 5 909 916
    • (1999) Clin Cancer Res , vol.5 , pp. 909-916
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 53
    • 0038140036 scopus 로고    scopus 로고
    • A multicentered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer
    • K Kelly N Hanna P Rosenberg 2003 A multicentered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer Proc Am Soc Clin Oncol 22 644
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 644
    • Kelly, K.1    Hanna, N.2    Rosenberg, P.3
  • 54
    • 0038816710 scopus 로고    scopus 로고
    • Phase IB/IIA study of anti-epidermal growth factor receptor (EGFR) antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced non-small cell lung cancer (NSCLC)
    • F Robert GR Blumenschein K Dicke 2003 Phase IB/IIA study of anti-epidermal growth factor receptor (EGFR) antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced non-small cell lung cancer (NSCLC) Proc Am Soc Clin Oncol 22 643
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 643
    • Robert, F.1    Blumenschein, G.R.2    Dicke, K.3
  • 55
    • 4444377694 scopus 로고    scopus 로고
    • Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC)
    • R Rosell C Daniel R Ramlau 2004 Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC) Proc Am Soc Clin Oncol 23 618
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 618
    • Rosell, R.1    Daniel, C.2    Ramlau, R.3
  • 56
    • 0030774045 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
    • JD Moyer EG Barbacci KK Iwata 1997 Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase Cancer Res 57 4838 4848
    • (1997) Cancer Res , vol.57 , pp. 4838-4848
    • Moyer, J.D.1    Barbacci, E.G.2    Iwata, K.K.3
  • 57
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • VA Pollack DM Savage DA Baker 1999 Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice J Pharmacol Exp Ther 291 739 748
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 739-748
    • Pollack, V.A.1    Savage, D.M.2    Baker, D.A.3
  • 58
    • 0242351391 scopus 로고    scopus 로고
    • Encouraging activity and durable responses demonstrated by the EGFR tyrosine kinase inhibitor erlotinib (Tarceva, OSI-774) in patients with advanced bronchioalveolar (BAC) cell carcinoma
    • JD Patel VA Miller MG Kris 2003 Encouraging activity and durable responses demonstrated by the EGFR tyrosine kinase inhibitor erlotinib (Tarceva, OSI-774) in patients with advanced bronchioalveolar (BAC) cell carcinoma Lung Cancer 41 S56
    • (2003) Lung Cancer , vol.41 , pp. 56
    • Patel, J.D.1    Miller, V.A.2    Kris, M.G.3
  • 59
    • 4444238981 scopus 로고    scopus 로고
    • Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)
    • July 15 Suppl.
    • U Gatzemeier A Pluzanska A Szczesna 2004 Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC) J Clin Oncol 22 July 15 Suppl. 619s
    • (2004) J Clin Oncol , vol.22
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 60
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • RS Herbst D Prager R Hermann 2005 TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer J Clin Oncol 23 5892 5899
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 61
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
    • G Giaccone RS Herbst C Manegold 2004 Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1 J Clin Oncol 22 777784
    • (2004) J Clin Oncol , vol.22 , pp. 777784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 62
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
    • RS Herbst G Giaccone JH Schiller 2004 Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2 J Clin Oncol 22 785 794
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 63
    • 33845321649 scopus 로고    scopus 로고
    • A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC)
    • June 20 Suppl
    • B Liu T Barrett P Choyke 2006 A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC) J Clin Oncol 24 June 20 Suppl 17119
    • (2006) J Clin Oncol , vol.24 , pp. 17119
    • Liu, B.1    Barrett, T.2    Choyke, P.3
  • 64
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • DB Mendel AD Laird X Xin 2003 In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship Clin Cancer Res 9 327 337
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 65
    • 0041672482 scopus 로고    scopus 로고
    • SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
    • AJ Schueneman E Himmelfarb L Geng 2003 SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models Cancer Res 63 4009 4016
    • (2003) Cancer Res , vol.63 , pp. 4009-4016
    • Schueneman, A.J.1    Himmelfarb, E.2    Geng, L.3
  • 66
    • 33751414107 scopus 로고    scopus 로고
    • Final results of a phase I study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor receptors (VEGFR), in combination with carboplatin (C) + paclitaxel (T) in patients with advanced non-small cell lung cancer (NSCLC): A study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)
    • June 20 Suppl
    • SA Laurie A Arnold I Gauthier 2006 Final results of a phase I study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor receptors (VEGFR), in combination with carboplatin (C) + paclitaxel (T) in patients with advanced non-small cell lung cancer (NSCLC): A study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) J Clin Oncol 24 June 20 Suppl 3054
    • (2006) J Clin Oncol , vol.24 , pp. 3054
    • Laurie, S.A.1    Arnold, A.2    Gauthier, I.3
  • 67
    • 29244480558 scopus 로고    scopus 로고
    • A randomized, placebo-controlled phase II trial of ZD6474 plus docetaxel in patients with NSCLC
    • June 1 Suppl
    • JV Heymach BE Johnson J Rowbottom 2005 A randomized, placebo-controlled phase II trial of ZD6474 plus docetaxel in patients with NSCLC J Clin Oncol 23 June 1 Suppl 197S
    • (2005) J Clin Oncol , vol.23
    • Heymach, J.V.1    Johnson, B.E.2    Rowbottom, J.3
  • 68
    • 21244501441 scopus 로고    scopus 로고
    • Preliminary phase II safety evaluation of ZD6474, in combination with carboplatin and paclitaxel, as 1st-line treatment in patients with NSCLC
    • June 1 Suppl
    • BE Johnson P Ma H West 2005 Preliminary phase II safety evaluation of ZD6474, in combination with carboplatin and paclitaxel, as 1st-line treatment in patients with NSCLC J Clin Oncol 23 June 1 Suppl 645S
    • (2005) J Clin Oncol , vol.23
    • Johnson, B.E.1    Ma, P.2    West, H.3
  • 69
    • 4444325685 scopus 로고    scopus 로고
    • A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC)
    • TJ Lynch R Lilenbaum P Bonomi 2004 A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC) Proc Am Soc Clin Oncol 23 634
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 634
    • Lynch, T.J.1    Lilenbaum, R.2    Bonomi, P.3
  • 70
    • 33751580192 scopus 로고    scopus 로고
    • A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: Final report
    • ES Kim AM Mauer H Tran 2003 A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: final report Proc Am Soc Clin Oncol 22 642
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 642
    • Kim, E.S.1    Mauer, A.M.2    Tran, H.3
  • 71
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • N Thatcher A Chang P Parikh 2005 Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) Lancet 366 1527 1537
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 72
    • 37349092482 scopus 로고    scopus 로고
    • Gefitinib (IRESSA) versus docetaxel in patients with locally advanced or metastatic non-small cell lung cancer pre-treated with platinum-based chemotherapy: A randomized, open-label phase III study (INTEREST)
    • JY Douillard E Kim V Hirsh 2007 Gefitinib (IRESSA) versus docetaxel in patients with locally advanced or metastatic non-small cell lung cancer pre-treated with platinum-based chemotherapy: a randomized, open-label phase III study (INTEREST) J Thorac Oncol 2 S305
    • (2007) J Thorac Oncol , vol.2 , pp. 305
    • Douillard, J.Y.1    Kim, E.2    Hirsh, V.3
  • 73
    • 41049090971 scopus 로고    scopus 로고
    • Results of a randomized phase III study to compare the overall survival of gefitinib versus docetaxel in Japanese patients with non-small cell lung cancer who failed one or two chemotherapy regimens
    • June 20 Suppl.
    • S Niho Y Ichinose T Tamura 2007 Results of a randomized phase III study to compare the overall survival of gefitinib versus docetaxel in Japanese patients with non-small cell lung cancer who failed one or two chemotherapy regimens J Clin Oncol 25 June 20 Suppl. 387s
    • (2007) J Clin Oncol , vol.25
    • Niho, S.1    Ichinose, Y.2    Tamura, T.3
  • 74
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • FA Shepherd PJ Rodrigues T Ciuleanu 2005 Erlotinib in previously treated non-small-cell lung cancer N Engl J Med 353 123 132
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues, P.J.2    Ciuleanu, T.3
  • 75
    • 33748445361 scopus 로고    scopus 로고
    • Symptom improvement in lung cancer patients treated with erlotinib: Quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • A Bezjak D Tu L Seymour 2006 Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21 J Clin Oncol 24 3831 3837
    • (2006) J Clin Oncol , vol.24 , pp. 3831-3837
    • Bezjak, A.1    Tu, D.2    Seymour, L.3
  • 76
    • 32944472661 scopus 로고    scopus 로고
    • OSI Pharmaceuticals. OSI Pharmaceuticals Melville
    • OSI Pharmaceuticals (2005) Tarceva prescribing information. OSI Pharmaceuticals, Melville
    • (2005) Tarceva Prescribing Information
  • 77
    • 49749090135 scopus 로고    scopus 로고
    • Sanofi-Aventis. Sanofi-Aventis Paris
    • Sanofi-Aventis (2005) Docetaxel prescribing information. Sanofi-Aventis, Paris
    • (2005) Docetaxel Prescribing Information
  • 79
    • 33748913369 scopus 로고    scopus 로고
    • Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma
    • June 20 Suppl
    • U Gatzemeier GR Blumenschein FV Fossella 2006 Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma J Clin Oncol 24 June 20 Suppl 7002
    • (2006) J Clin Oncol , vol.24 , pp. 7002
    • Gatzemeier, U.1    Blumenschein, G.R.2    Fossella, F.V.3
  • 80
    • 21244488907 scopus 로고    scopus 로고
    • ZD6474-clinical experience to date
    • Suppl. 1
    • JV Heymach 2005 ZD6474-clinical experience to date Br J Cancer 92 Suppl. 1 S14 20
    • (2005) Br J Cancer , vol.92 , pp. 14-20
    • Heymach, J.V.1
  • 81
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • RS Herbst DH Johnson E Mininberg 2005 Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer J Clin Oncol 23 2544 2555
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 82
    • 34247467122 scopus 로고    scopus 로고
    • A phase II, multicenter, randomized clinical trial to evaluate the efficacy and safety of bevacizumab (Avastin®) in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride (Tarceva®) compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer
    • RS Herbst L Fehrenbacher CP Belani 2006 A phase II, multicenter, randomized clinical trial to evaluate the efficacy and safety of bevacizumab (Avastin®) in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride (Tarceva®) compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer Eur J Cancer Suppl 4 20
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 20
    • Herbst, R.S.1    Fehrenbacher, L.2    Belani, C.P.3
  • 83
    • 33646684694 scopus 로고    scopus 로고
    • Treatment of non-small-cell lung cancer and pharmacogenomics: Where we are and where we are going
    • R Rosell M Cuello F Cecere 2006 Treatment of non-small-cell lung cancer and pharmacogenomics: where we are and where we are going Curr Opin Oncol 18 135 143
    • (2006) Curr Opin Oncol , vol.18 , pp. 135-143
    • Rosell, R.1    Cuello, M.2    Cecere, F.3
  • 84
    • 33745728326 scopus 로고    scopus 로고
    • Predicting the outcome of chemotherapy for lung cancer
    • R Rosell F Cecere M Santarpia 2006 Predicting the outcome of chemotherapy for lung cancer Curr Opin Pharmacol 6 323 331
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 323-331
    • Rosell, R.1    Cecere, F.2    Santarpia, M.3
  • 85
    • 33646848944 scopus 로고    scopus 로고
    • From the bench to the bed: Individualizing treatment in non-small-cell lung cancer
    • M Santarpia G Altavilla F Salazar 2006 From the bench to the bed: individualizing treatment in non-small-cell lung cancer Clin Transl Oncol 8 71 76
    • (2006) Clin Transl Oncol , vol.8 , pp. 71-76
    • Santarpia, M.1    Altavilla, G.2    Salazar, F.3
  • 86
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer-molecular and clinical predictors of outcome
    • MS Tsao A Sakurada JC Cutz 2005 Erlotinib in lung cancer-molecular and clinical predictors of outcome N Engl J Med 353 133 144
    • (2005) N Engl J Med , vol.353 , pp. 133-144
    • Tsao, M.S.1    Sakurada, A.2    Cutz, J.C.3
  • 88
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • MS Gordon K Margolin M Talpaz 2001 Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer J Clin Oncol 19 843 850
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 89
    • 49749111545 scopus 로고    scopus 로고
    • First-line bevacizumab in combination with chemotherapy in the treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): An open-label safety study (MO19390)
    • L Crino E Dansin P Garrido Lopez 2007 First-line bevacizumab in combination with chemotherapy in the treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): an open-label safety study (MO19390) European Journal of Cancer Supplements 5 386
    • (2007) European Journal of Cancer Supplements , vol.5 , pp. 386
    • Crino, L.1    Dansin, E.2    Garrido Lopez, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.