Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: Effects of a single dose of 5-fluorouracil

Journal of Applied Toxicology

Volumn 28, Issue 6, 2008, Pages 797-805

  Tsuboi, Isao ^a   Hirabayashi, Yoko ^b   Harada, Tomonori ^a   Koshinaga, Morimichi ^a   Kawamata, Tatsuro ^a   Kanno, Jun ^b   Inoue, Tohru ^b   Aizawa, Shin ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Aging; B lymphopoiesis; Hematopoietic microenvironment; Stromal cell impairment (SCI) mice; Subline of senescence accelerated mice (SAMP1)

Indexed keywords

FLUOROURACIL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL MATURATION; CELL REGENERATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; HEMATOPOIESIS; LYMPHOCYTOPOIESIS; LYMPHOPOIESIS; MOUSE; MYELOPOIESIS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SENESCENCE ACCELERATED MOUSE; STROMA CELL; UPREGULATION;

AGING; ANIMALS; ANTIMETABOLITES; B-LYMPHOCYTES; BLOOD CELLS; BONE MARROW CELLS; COLONY-FORMING UNITS ASSAY; CYTOKINES; ENVIRONMENT; FLUOROURACIL; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; MICE; MICE, INBRED STRAINS; PRINCIPAL COMPONENT ANALYSIS; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; STROMAL CELLS;

MUS;

EID: 49649106937     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1341     Document Type: Article

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