Cellular localization and distribution of dopamine D4 receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks

Neuroscience

Volumn 155, Issue 3, 2008, Pages 997-1010

  Rivera, A ^a   Penafiel A ^a   Megias M ^b   Agnati, L F ^c,d   Lopez Tellez J F ^a,f   Gago, B ^a   Gutierrez A ^a,f   de la Calle, A ^a   Fuxe, K ^e  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b UNIVERSITY OF VIGO   (Spain)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d IRCCS SAN CAMILLO HOSPITAL   (Italy)

^e KAROLINSKA INSTITUTE   (Sweden)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

catecholamine; D2 like receptors; immunohistochemistry; volume transmission

Indexed keywords

DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; NORADRENALIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY CORTEX; BRAIN CORTEX; CELLULAR DISTRIBUTION; CINGULATE GYRUS; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; ENTORHINAL CORTEX; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; INSULA; MALE; MOTOR CORTEX; NERVE CELL NETWORK; NERVE ENDING; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; RECEPTOR AFFINITY; SOMATOSENSORY CORTEX; TEMPORAL CORTEX; VISUAL CORTEX;

ANALYSIS OF VARIANCE; ANIMALS; CEREBRAL CORTEX; DOPAMINE; DOPAMINE BETA-HYDROXYLASE; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; NERVE ENDINGS; NEURONS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D4; TYROSINE 3-MONOOXYGENASE;

EID: 49449115824     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.05.060     Document Type: Article

References (84)

1. Agnati L.F., Leo G., Zanardi A., Genedani S., Rivera A., Fuxe K., and Guidolin D. Volume transmission and wiring transmission from cellular to molecular networks: history and perspectives. Acta Physiol 187 (2006) 329-344
2. Agnati L.F., Genedani S., Leo G., Rivera A., Guidolin D., and Fuxe K. One century of progress in neuroscience founded on Golgi and Cajal outstanding experimental and theoretical contributions. Brain Res Rev 55 (2007) 167-189
3. Al-Tikriti M.S., Roth R.H., Kessler R.M., and Innis R.B. Autoradiographic localization of dopamine D1 and D2 receptors in rat cerebral cortex following unilateral neurotoxic lesions. Brain Res 575 (1992) 39-46
4. Anden N.E., Dahlstrom A., Fuxe K., and Larsson K. Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and diencephalon. Life Sci 4 (1965) 1275-1279
5. Anden N.E., Fuxe K., and Ungerstedt U. Monoamine pathways to the cerebellum and cerebral cortex. Experientia 23 (1967) 838-839
6. Aoki C., Joh T.H., and Pickel V.M. Ultrastructural localization of beta-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain. Brain Res 437 (1987) 264-282
7. Aoki C. Beta-adrenergic receptors: Astrocytic localization in the adult visual cortex and their relation to catecholamine axon terminals as revealed by electron microscopic immunocytochemistry. J Neurosci 12 (1992) 781-792
8. Aoki C., and Pickel V.M. Ultrastructural relations between beta-adrenergic receptors and catecholaminergic neurons. Brain Res Bull 29 (1992) 257-263
9. Aoki C., Go C.G., Venkatesan C., and Kurose H. Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity. Brain Res 650 (1994) 181-204
10. Aoki C., Venkatesan C., Go C.G., Forman R., and Kurose H. Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons. Cereb Cortex 8 (1998) 269-277
11. Ariano M.A., Wang J., Noblett K.L., Larson E.R., and Sibley D.R. Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera. Brain Res 752 (1997) 26-34
12. Ariano M.A., Wang J., Noblett K.L., Larson E.R., and Sibley D.R. Cellular distribution of the rat D1B receptor in central nervous system using anti-receptor antisera. Brain Res 746 (1997) 141-150
13. Avale M.E., Falzone T.L., Gelman D.M., Low M.J., Grandy D.K., and Rubinstein M. The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder. Mol Psychiatry 9 (2004) 718-726
14. Berger B., Tassin J.P., Blanc G., Moyne M.A., and Thierry A.M. Histochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways. Brain Res 81 (1974) 332-337
15. Berger B., Thierry A.M., Tassin J.P., and Moyne M.A. Dopaminergic innervation of the rat prefrontal cortex: a fluorescence histochemical study. Brain Res 106 (1976) 133-145
16. Berger B., Verney C., Alvarez C., Vigny A., and Helle K.B. New dopaminergic terminal fields in the motor, visual (area 18b) and retrosplenial cortex in the young and adult rat. Immunocytochemical and catecholamine histochemical analyses. Neuroscience 15 (1985) 983-998
17. Biederman J., and Spencer T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46 (1999) 1234-1242
18. Ciliax B.J., Nash N., Heilman C., Sunahara R., Hartney A., Tiberi M., Rye D.B., Caron M.G., Niznik H.B., and Levey A.I. Dopamine D(5) receptor immunolocalization in rat and monkey brain. Synapse 37 (2000) 125-145
19. 35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine. Eur J Pharmacol 531 (2006) 20-24
20. Defagot M.C., and Antonelli M.C. Autoradiographic localization of the putative D4 dopamine receptor in rat brain. Neurochem Res 22 (1997) 401-407
21. Defagot M.C., Malchiodi E.L., Villar M.J., and Antonelli M.C. Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies. Brain Res Mol Brain Res 45 (1997) 1-12
22. Defagot M.C., Falzone T.L., Low M.J., Grandy D.K., Rubinstein M., and Antonelli M.C. Quantitative analysis of the dopamine D4 receptor in the mouse brain. J Neurosci 59 (2000) 202-208
23. De La Garza R., and Madras B.K. [(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse 37 (2000) 232-244
24. Descarries L., Watkins K.C., and Lapierre Y. Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis. Brain Res 133 (1977) 197-222
25. Descarries L., Lemay B., Doucet G., and Berger B. Regional and laminar density of the dopamine innervation in adult rat cerebral cortex. Neuroscience 21 (1987) 807-824
26. Dulawa S.C., Grandy D.K., Low M.J., Paulus M.P., and Geyer M.A. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci 19 (1999) 9550-9556
27. Ebstein R.P., Novick O., Umansky R., Priel B., Osher Y., Blaine D., Bennett E.R., Nemanov L., Katz M., and Belmaker R.H. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12 (1996) 78-80
28. Ebstein R.P., Benjamin J., and Belmaker R.H. Personality and polymorphisms of genes involved in aminergic neurotransmission. Eur J Pharmacol 410 (2000) 205-214
29. Floresco S.B., and Magyar O. Mesocortical dopamine modulation of executive functions: beyond working memory. Psychopharmacology 188 (2006) 567-585
30. Fuxe K. Evidence for the existence of monoamine neurons iIn the central nervous system. 3. The monoamine nerve terminal. Z Zellforsch Mikrosk Anat 65 (1965) 573-596
31. Fuxe K. Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiol Scand Suppl 247 (1965) 37
32. Fuxe K., Hamberger B., and Hokfelt T. Distribution of noradrenaline nerve terminals in cortical areas of the rat. Brain Res 8 (1968) 125-131
33. Fuxe K., Hokfelt T., Johansson O., Jonsson G., Lidbrink P., and Ljungdahl A. The origin of the dopamine nerve terminals in limbic and frontal cortex. Evidence for meso-cortico dopamine neurons. Brain Res 82 (1974) 349-355
34. Fuxe K., Jacobsen K.X., Hoistad M., Tinner B., Jansson A., Staines W.A., and Agnati L.F. The dopamine D1 receptor-rich main and paracapsular intercalated nerve cell groups of the rat amygdala: relationship to the dopamine innervation. Neuroscience 119 (2003) 733-746
35. Fuxe K., Rivera A., Jacobsen K.X., Hoistad M., Leo G., Horvath T.L., Staines W., De la Calle A., and Agnati L.F. Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2. J Neural Transm 112 (2005) 65-76
36. Fuxe K., Dahlström A., Höistad M., Marcellino D., Jansson A., Rivera A., Jacobsen K., Diaz-Cabiale Z., Tinner-Staines B., Staines W., Leo G., Guidolin D., Kehr J., Genedani S., Belluardo N., and Agnati L. From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and Volume transmission. Brain Res Rev 55 (2007) 17-54
37. Goldman-Rakic P.S., Leranth C., Williams S.M., Mons N., and Geffard M. Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex. Proc Natl Acad Sci U S A 86 (1989) 9015-9019
38. Goldman-Rakic P.S. The cortical dopamine system: role in memory and cognition. Adv Pharmacol 42 (1998) 707-711
39. Gonzalez-Islas C., and Hablitz J.J. Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex. J Neurosci 23 (2003) 867-875
40. Horvath T.L., Diano S., and Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol 65 (2003) 1917-1921
41. Jansson A., Goldstein M., Tinner B., Zoli M., Meador-Woodruff J.H., Lew J.Y., Levey A.I., Watson S., Agnati L.F., and Fuxe K. On the distribution patterns of D1, D2, tyrosine hydroxylase and dopamine transporter immunoreactivities in the ventral striatum of the rat. Neuroscience 89 (1999) 473-489
42. Jansson A., Tinner B., Bancila M., Verge D., Steinbusch H.W., Agnati L.F., and Fuxe K. Relationships of 5-hydroxytryptamine immunoreactive terminal-like varicosities to 5-hydroxytryptamine-2A receptor-immunoreactive neuronal processes in the rat forebrain. J Chem Neuroanat 22 (2001) 185-203
43. Khan Z.U., Gutierrez A., Martin R., Penafiel A., Rivera A., and De la Calle A. Differential regional and cellular distribution of dopamine D2-like receptors: an immunocytochemical study of subtype-specific antibodies in rat and human brain. J Comp Neurol 402 (1998) 353-371
44. Khan Z.U., Gutierrez A., Martin R., Penafiel A., Rivera A., and de la Calle A. Dopamine D5 receptors of rat and human brain. Neuroscience 100 (2000) 689-699
45. Lahti R.A., Evans D.L., Stratman N.C., and Figur L.M. Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol 236 (1993) 483-486
46. Lanau F., Zenner M.T., Civelli O., and Hartman D.S. Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J Neurochem 68 (1997) 804-812
47. Levitt P., and Moore R.Y. Noradrenaline neuron innervation of the neocortex in the rat. Brain Res 139 (1978) 219-231
48. Lidow M.S., Wang F., Cao Y., and Goldman-Rakic P.S. Layer V neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortex. Synapse 28 (1998) 10-20
49. Lindvall O., and Björklund A. The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol Scand Suppl 412 (1974) 1-48
50. Matsumoto M., Hidaka K., Tada S., Tasaki Y., and Yamaguchi T. Full-length cDNA cloning and distribution of human dopamine D4 receptor. Brain Res Mol Brain Res 29 (1995) 157-162
51. Mauger C., Sivan B., Brockhaus M., Fuchs S., Civelli O., and Monsma Jr. F. Development and characterization of antibodies directed against the mouse D4 dopamine receptor. Eur J Neurosci 10 (1998) 529-537
52. Meador-Woodruff J.H., Grandy D.K., Van Tol H.H., Damask S.P., Little K.Y., Civelli O., and Watson Jr. S.J. Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10 (1994) 239-248
53. Meador-Woodruff J.H., Haroutunian V., Powchik P., Davidson M., Davis K.L., and Watson S.J. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. Arch Gen Psychiatry 54 (1997) 1089-1095
54. Missale C., Nash S.R., Robinson S.W., Jaber M., and Caron M.G. Dopamine receptors: from structure to function. Physiol Rev 78 (1998) 189-225
55. Mrzljak L., Bergson C., Pappy M., Huff R., Levenson R., and Goldman-Rakic P.S. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 381 (1996) 245-248
56. Newman-Tancredi A., Audinot-Bouchez V., Gobert A., and Millan M.J. Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors. Eur J Pharmacol 319 (1997) 379-383
57. Nicholas A.P., Pieribone V., and Hökfelt T. Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol 328 (1993) 575-594
58. Noain D., Avale M.E., Wedemeyer C., Calvo D., Peper M., and Rubinstein M. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. Eur J Neurosci 24 (2006) 2429-2438
59. Oak J.N., Oldenhof J., and Van Tol H.H. The dopamine D(4) receptor: one decade of research. Eur J Pharmacol 405 (2000) 303-327
60. Onn S.P., Wang X.B., Lin M., and Grace A.A. Dopamine d1 and d4 receptor subtypes differentially modulate recurrent excitatory synapses in prefrontal cortical pyramidal neurons. Neuropsychopharmacology 31 (2006) 318-338
61. Papay R., Gaivin R., Jha A., McCune D.F., McGrath J.C., Rodrigo M.C., Simpson P.C., Doze V.A., and Perez D.M. Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. J Comp Neurol 497 (2006) 209-222
62. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1998), Academic Press, Sydney
63. Pfeiffer U.J., and Fendt M. Prefrontal dopamine D4 receptors are involved in encoding fear extinction. Neuroreport 17 (2006) 847-850
64. Powell S.B., Paulus M.P., Hartman D.S., Godel T., and Geyer M.A. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 (2003) 473-481
65. Primus R.J., Thurkauf A., Xu J., Yevich E., McInerney S., Shaw K., Tallman J.F., and Gallagher D.W. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J Pharmacol Exp Ther 282 (1997) 1020-1027
66. Rainbow T.C., Parsons B., and Wolfe B.B. Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain. Proc Natl Acad Sci U S A 81 (1984) 1585-1589
67. Rinaman L. Postnatal development of catecholamine inputs to the paraventricular nucleus of the hypothalamus in rats. J Comp Neurol 438 (2001) 411-422
68. Rivera A., Cuellar B., Giron F.J., Grandy D.K., de la Calle A., and Moratalla R. Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum. J Neurochem 80 (2002) 219-229
69. Rivera A., Trias S., Penafiel A., Angel Narvaez J., Diaz-Cabiale Z., Moratalla R., and de la Calle A. Expression of D4 dopamine receptors in striatonigral and striatopallidal neurons in the rat striatum. Brain Res 989 (2003) 35-41
70. Rivera A., Agnati L.F., Horvath T.L., Valderrama J.J., de la Calle A., and Fuxe K. Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: relevance for volume transmission. Neuroscience 137 (2006) 1447-1461
71. Rubinstein M., Cepeda C., Hurst R.S., Flores-Hernandez J., Ariano M.A., Falzone T.L., Kozell L.B., Meshul C.K., Bunzow J.R., Low M.J., Levine M.S., and Grandy D.K. Dopamine D4 receptor-deficient mice display cortical hyperexcitability. J Neurosci 21 (2001) 3756-3763
72. 3H]SCH 23390. Brain Res 375 (1986) 291-301
73. Shah A., Sjovold T., and Treit D. Selective antagonism of medial prefrontal cortex D4 receptors decreases fear-related behaviour in rats. Eur J Neurosci 19 (2004) 3393-3397
74. Tarazi F.I., Kula N.S., and Baldessarini R.J. Regional distribution of dopamine D4 receptors in rat forebrain. Neuroreport 8 (1997) 3423-3426
75. Tarazi F.I., Campbell A., Yeghiayan S.K., and Baldessarini R.J. Localization of dopamine receptor subtypes in corpus striatum and nucleus accumbens septi of rat brain: comparison of D1-, D2-, and D4-like receptors. Neuroscience 83 (1998) 169-176
76. Tarazi F.I., Zhang K., and Baldessarini R.J. Dopamine D4 receptors: beyond schizophrenia. J Recept Signal Transduct Res 24 (2004) 131-147
77. Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl 367 (1971) 1-48
78. Van Tol H.H., Bunzow J.R., Guan H.C., Sunahara R.K., Seeman P., Niznik H.B., and Civelli O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350 (1991) 610-614
79. Vincent S.L., Khan Y., and Benes F.M. Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortex. J Neurosci 13 (1993) 2551-2564
80. Wang X., Zhong P., and Yan Z. Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. J Neurosci 22 (2002) 9185-9193
81. Wang X., Zhong P., Gu Z., and Yan Z. Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex. J Neurosci 23 (2003) 9852-9861
82. Wedzony K., Chocyk A., Mackowiak M., Fijal K., and Czyrak A. Cortical localization of dopamine D4 receptors in the rat brain: immunocytochemical study. J Physiol Pharmacol 51 (2000) 205-221
83. Wu J., and Hablitz J.J. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci 25 (2005) 6322-6328
84. Young C.E., and Yang C.R. Dopamine D1-like receptor modulates layer- and frequency-specific short-term synaptic plasticity in rat prefrontal cortical neurons. Eur J Neurosci 21 (2005) 3310-3320