Quantitative analysis of the dopamine D4 receptor in the mouse brain

Journal of Neuroscience Research

Volumn 59, Issue 2, 2000, Pages 202-208

  Defagot, María Cristina ^a   Falzone, Tomás L ^b   Low, Malcolm J ^c   Grandy, David K ^c   Rubinstein, Marcelo ^b   Antonelli, Marta C ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Inst Invest Ing Genet y B   (Argentina)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Benzamides binding; D2 type receptors; D4 knockout mice

Indexed keywords

BENZAMIDE; DOPAMINE 4 RECEPTOR; EMONAPRIDE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN; BRAIN REGION; CONTROLLED STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ASSAY; RECEPTOR BINDING; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ANIMALS; AUTORADIOGRAPHY; BENZAMIDES; BINDING SITES; BRAIN CHEMISTRY; DOPAMINE ANTAGONISTS; FEMALE; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; QUANTITATIVE TRAIT, HERITABLE; RACLOPRIDE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SYNAPTOSOMES; TRITIUM;

EID: 0034650968     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(20000115)59:2<202::AID-JNR6>3.0.CO;2-5     Document Type: Article

References (39)

1. 2+ cannels present in synaptosomes from rat and chicken central nervous system. J Neurochem 64:2544-2551.
2. 3H]ouabain in cerebral cortex of rabbit brain ussing quantitative autoradiography. J Neurochem 52:193-200.
3. Ariano MA, Wang J, Noblett KL, Larson ER, Sibley DR. 1997. Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera. Brain Res 752:26-34.
4. Baldessarini RJ, Tarazi FI. 1996. Brain dopamine receptors: a primer on their current status, basic and clinical. Harvard Rev Psychiatr 3:301-325.
5. 33P. J Histochem Cytochem 41:1767-1776.
6. Baskin DG, Filuk PE, Stahl WL. 1989. Standardization of tritium sensitive film for quantitative autoradiography. J Histochem Cytochem 37:1337-1344
7. Defagot MC, Antonelli MC. 1997. Autordiographic localization of the putative D4 dopamine receptor in rat brain. Neurochem Res 22:401-407
8. Defagot M C, Malchiodi EL, Villar MJ, Antonelli MC. 1997. Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies. Mol Brain Res 45:1-12.
9. Farooqui SM, Brock JW, Hamdi A, Prasad C. 1991. Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum. J Neurochem 57:1363-1369.
10. 3H]Clozapine is not a suitable radioligand for the labelling of D4 dopamine receptors in postmorten human brain. Neurosci Lett 175:17-20.
11. 3H]nemonapride. Eur J Pharmacol 301:R1-R3.
12. 3H]nemonapride binding sites in calf brain. Arch Pharmacol 356:17-21
13. Kahn RS, Davis KL. 1995. New developments in dopamine and shizophrenia. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press. p 1193-1203.
14. 3H]raclopride. A potent substituted benzamide drug with high affinity for dopamine D2 receptors in the rat brain. Biochem Pharmacol 34:2251-2259.
15. Lahti RA, Roberts RC, Tamminga CA. 1995. D2 family receptor distribution in human postmorten tissue: an autoradiographic study. Neuro-report 6:2505-2512.
16. Lahti RA, Roberts RC, Conley RR, Cochrane EV, Mutin A, Tamminga CA. 1996. D2-type dopamine receptors in postmorten human brain sections from normal and schizophrenic subjects. Neuroreport 7:1945-1948.
17. 3H]NGD-94-1 study. Mol Psychiatr 3:528-533.
18. Lowry OH, Rosebrough, NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J. Biol Chem 193:265-275.
19. Mansour A, Meador Woodruff J, Burke S, Bunzow J, Akil H, Van Tol HHM, Civelli O, Watson SJ. 1991. Differential distribution of D2 and D4 dopamine receptor mRNA in the rat brain: an in situ hybridization study. Soc Neurosci Abstr 17:599
20. Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. 1996. Localization of dopamine D4 receptor in GABAergic neurons of the primate brain. Nature 381:245-248.
21. Murray AM, Hyde TM, Knable MB, Herman MM, Bigelow LB, Carter JM, Weinberger DR, Kleinman JE. 1995. Distribution of putative D4 dopamine receptorin postmorten striatum from patients with schizophrenia. J Neurosci 15:2186-2191.
22. O'Malley KL, Harmon S, Tang L, Todd RD. 1992. The rat D4 dopamine receptor: sequence, gene structure and demonstrationof expression in the cardiovascular system. New Biol 4:137-146.
23. 3H]NGD-94-1. J Pharmacol Exp Ther 282:1020-1027.
24. Reynolds GP, Mason SL. 1994. Are striatal dopamine D4 receptors increased in schizophrenia? J Neurochem 63:1576-1577.
25. Reynolds GP, Mason SL. 1995, Absence of detectable striatal dopamine D4 receptors in drug-treated schizophrenia. Eur J Pharmacol 281.R5-R6.
26. Rubinstein M, Phillips TJ, Bunzow JR. Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, Mc Dougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK. 1997. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90:991-1001.
27. Stahl WL, Baskin DG. 1990. Histochemistry of ATPases. J Histochem Cytochem 38:1099-1122.
28. Seeman P. 1995. Dopamine receptors. Clinical correlates. In Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press, p 295-302.
29. Seeman P, Guan H-C. Van Tol HHM. 1993a. Dopamine D4 receptors elevated in schizophrenia. Nature 365:441-445.
30. Seeman P, Guan H-C, Van Tol HHM, Niznik HB 1993b. Low density of dopamine D4 rceptors in Parkinson's, Schizophrenia and control brain striata. Synapse 14:247-253.
31. 3H] raclopride binding in postmorten caudate nucleus of sujects with schizophrenia or major depression. Brain Res 681:109-116.
32. 3H]raclopride in postmorten human brains, Brain Res 765:7-12.
33. Tarazi Fl, Baldessarini RJ. 1999) Brain dopamine D4 receptors basic and clinical status. Int J Neuropharmacol 2:41-58.
34. Tarazi Fl., Kula NS, Baldessarini RJ. 1997. Regional distribution of dopamine D4 receptors in rat forebrain. Neuroreport 8:3423-3426.
35. Tarazi FI, Campbell A, Yeghiayan SK, Baldessarini RJ. 1998. Localization of dopamine receptos subtypes in caudate-putamen and nucleus accumbens septi: comparison of D1-, D2- and D4-like receptors. Neuroscience 83:169-176.
36. 3H]raclopride for dopamine D2 receptor binding to rat striatum. Eur J Pharmacol 173:177-182.
37. 2 receptor subtypes. Neuroreport 7:1057-1061
38. Van Tol, HHM, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O. 1991. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614.
39. 3H]Spiperone label equivalent numbers of D2 and D3 dopamine receptors in a range of tissues and under different conditions. J Neurochem 64:940-943.