The primary cilium as a gravitational force transducer and a regulator of transcriptional noise

Developmental Dynamics

Volumn 237, Issue 8, 2008, Pages 1955-1959

  Moorman, Stephen J ^a   Shorr, Ardon Z ^a,b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b OBERLIN COLLEGE   (United States)

Author keywords

Gravity; Primary cilium; Rohon beard neuron; Transcriptional noise; Vertebrate cells; Zebrafish

Indexed keywords

BETA ACTIN; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; NEUROGENIN 3; POLYCYSTIN 1; POLYCYSTIN 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR FLI 1; WNT PROTEIN;

BIOGENESIS; CELL GROWTH; CELL POPULATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CILIARY MOTILITY; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GRAVITY; HUMAN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SPINAL GANGLION; STOCHASTIC MODEL; TRANSCRIPTION REGULATION; ZEBRA FISH;

ANIMALS; CILIA; GENE EXPRESSION REGULATION; GRAVITY PERCEPTION; NEURONS; TRANSCRIPTION, GENETIC; WEIGHTLESSNESS SIMULATION;

DANIO RERIO; VERTEBRATA;

EID: 49449092788     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21493     Document Type: Review

References (32)

1. Alieva IB, Vorobjev IA. 2004. Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a "sleeping beauty" in cultured cells? Cell Biol Int 28:139-150.
2. Arias AM, Hayward P. 2006. Filtering transcriptional noise during development: concepts and mechanisms. Nat Rev Genet 7:34-44.
3. Cano DA, Murcia NS, Pazour GJ, Hebrok M. 2004. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131:3457-3467.
4. Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. 2005. Vertebrate Smoothened functions at the primary cilium. Nature 437:1018-1021.
5. Elowitz MB, Levine AJ, Siggia ED, Swain PS. 2002. Stochastic gene expression in a single cell. Science 297:1183-1186.
6. Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, Dolle P, Franco B. 2006. Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet 38:112-117.
7. Gherman A, Davis EE, Katsanis N. 2006. The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia. Nat Genet 38:961-962.
8. Hou X, Mrug M, Yoder BK, Lefkowitz EJ, Kremmidiotis G, D'Eustachio P, Beier DR, Guay-Woodford LM. 2002. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest 109: 533-540.
9. Iomini C, Tejada K, Mo W, Vaananen H, Piperno G. 2004. Primary cilia of human endothelial cells disassemble under laminar shear stress. J Cell Biol 164:811-817.
10. Kidd KR, Weinstein BM. 2003. Fishing for novel angiogenic therapies. Br J Pharmacol 140:585-594.
11. Otto EA, Schermer B, Obara T, O'Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D, Foreman JW, Goodship JA, Strachan T, Kispert A, Wolf MT, Gagnadoux MF, Nivet H, Antignac C, Walz G, Drummond IA, Benzing T, Hildebrandt F. 2003. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet 34:413-420.
12. Pan J, Wang Q, Snell WJ. 2005. Cilium-generated signaling and cilia-related disorders. Lab Invest 85:452-463.
13. Paulsson J. 2004. Summing up the noise in gene networks. Nature 427:415-418.
14. Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. 2000. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151:709-718.
15. Praetorius HA, Spring KR. 2003. Removal of the MDCK cell primary cilium abolishes flow sensing. J Membr Biol 191:69-76.
16. Praetorius HA, Praetorius J, Nielsen S, Frokiaer J, Spring KR. 2004. Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling. Am J Physiol Renal Physiol 287:F969-978.
17. Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S. 2006. Stochastic mRNA synthesis in mammalian cells. PLoS Biol 4:e309.
18. Resnick A, Hopfer U. 2007. Force-response considerations in ciliary mechanosensation. Biophys J 93:1380-1390.
19. Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A, Kirkegaard-Sorensen T, Varet B, Solary E, Garrido C, Hermine O. 2007. Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445: 102-105.
20. Satir P, Christensen ST. 2007. Overview of structure and function of mammalian cilia. Annu Rev Physiol 69:377-400.
21. Shimada N, Moorman SJ. 2006. Changes in gravitational force cause changes in gene expression in the lens of developing zebrafish. Dev Dyn 235:2686-2694.
22. Shimada N, Sokunbi G, Moorman SJ. 2005. Changes in gravitational force affect gene expression in developing organ systems at different developmental times. BMC Dev Biol 5:10.
23. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kronig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G. 2005. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 37: 537-543.
24. Tamakoshi T, Itakura T, Chandra A, Uezato T, Yang Z, Xue XD, Wang B, Hackett BP, Yokoyama T, Miura N. 2006. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem Biophys Res Commun 339:932-938.
25. Taulman PD, Haycraft CJ, Balkovetz DF, Yoder BK. 2001. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol Biol Cell 12:589-599.
26. Van der Heiden K, Groenendijk BC, Hierck BP, Hogers B, Koerten HK, Mommaas AM, Gittenberger-de Groot AC, Poelmann RE. 2006. Monocilia on chicken embryonic endocardium in low shear stress areas. Dev Dyn 235:19-28.
27. Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJ, Alkemade FE, Deruiter MC, Gittenberger-de Groot AC, Poelmann RE. 2008. Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. Atherosclerosis 196:542-550.
28. Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, Yokoyama T, Hamada H. 2003. The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development 130:1725-1734.
29. Whitfield JF. 2003. Primary cilium: is it an osteocyte's strain-sensing flowmeter? J Cell Biochem 89:233-237.
30. Wilson L, Maden M. 2005. The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev Biol 282:1-13.
31. Yoder BK, Hou X, Guay-Woodford LM. 2002a. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13:2508-2516.
32. Yoder BK, Tousson A, Millican L, Wu JH, Bugg CE, Jr., Schafer JA, Balkovetz DF. 2002b. Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium. Am J Physiol Renal Physiol 282:F541-552.