p16 expression in squamous lesions of the female genital tract

Journal of Molecular Histology

Volumn 35, Issue 2, 2004, Pages 111-114

  Finegan, Mary M ^a   Han, Aaron C ^a   Edelson, Mitchell I ^b   Rosenblum, Norman G ^c  

^a READING HOSPITAL AND MEDICAL CENTER   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; PROTEIN P16INK4A;

ARTICLE; CANCER GRADING; CARCINOMA IN SITU; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENDOMETRIUM CARCINOMA; FEMALE; GYNECOLOGIC CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; UTERINE CERVIX CARCINOMA; VAGINA CARCINOMA; VULVA CARCINOMA; FEMALE GENITAL SYSTEM; FEMALE GENITAL TRACT TUMOR; GENETICS; METABOLISM; METASTASIS; PAPILLOMA VIRUS; PATHOLOGY;

CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENITAL NEOPLASMS, FEMALE; GENITALIA, FEMALE; HUMANS; NEOPLASM METASTASIS; PAPILLOMAVIRIDAE;

EID: 4944266361     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:HIJO.0000023373.40704.ff     Document Type: Article

References (21)

1. INK4A antigen in thin-layer liquid-based specimens. Acta Cytol 46: 25-29.
2. INK4 and retinoblastomaprotein Rb in vulvar lesions of Chinese women. Gynecol Oncol 68: 156-161.
3. INK4a-imposed G1 cell cycle arrest. J Virol 75: 4705-4712.
4. Hirama T, Miller CW, Wilczynski SP, Koeffler HP (1996) p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinoma cell lines. Mod Pathol 9: 26-31.
5. INK4 are complementary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol 25: 884-891.
6. Keating JT, Ince T, Crum CP (2001b) Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv Anat Pathol 8: 82-92.
7. ink4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers. Exp Mol Med 30: 109-114.
8. Kim YT, Cho NH, Park SW, Kim JW (1998b) Underexpression of cyclin-dependent kinase (CDK) inhibitors in cervical carcinoma. Gynecol Oncol 71: 38-45.
9. Klaes R, Benner A, Friedrich T, Ridder R, Herrington S, Jenkins D, Kurman, RJ, Schmidt D, Stoler M, von Knebel Doeberitz MK (2002) p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26: 1389-1399.
10. INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92: 276-284.
11. Liggett WH, Sidransky D (1998) Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 16: 1197-1206.
12. Lin WM, Ashfaq R, Michalopulos EA, Maitra A, Gazdar AF, Muller CY (2000) Molecular Papanicolaou tests in the twenty-first century: Molecular analyses with fluid-based Papanicolaou technology. Am J Obstet Gynecol 183: 39-45.
13. Lorincz AT (1996) Hybrid capture method for detection of human papillomavirus DNA in clinical specimens. J Obstet Gynaecol Res 22: 629-636.
14. Nakao Y, yang X, Yokoyama M, Ferenczy A, Tang S-C, Pater MM, Pater A (1997) Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation. Brit J Cancer 75: 1410-1416.
15. Nakashima R, Fujita M, Enomoto T, Haba T, Yoshino K, Wada HKH, Sasaki M, Wakasa K, Inoue M, Buzard G, Murata Y (1999) Alteration of p16 and p15 genes in human uterine tumours. Br J Cancer 80: 458-467.
16. INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors. An immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 27: 187-193.
17. ink4A expression in normal human adult and infant tissues. Lab Invest 79: 1137-1143.
18. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T (1998) Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153: 1741-1748.
19. Sano T, Masuda N, Oyama T, Nakajima T (2002) Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol Int 52: 375-383.
20. ink4A in primary gynecologic malignancy. Cancer Lett 136: 231-235.
21. Yoshinouchi M, Hongo A, Takamoto N, Ono T, Nagoa S, Miyagi Y, Kudo T, Kodama J (2000) Alteration of the CDKN2/p16 gene is not required for HPV-positive uterine cervical cancer cell lines. Int J Oncol 16: 537-541.