The two-pore-domain K+ channels TREK-1 and TASK-3 are differentially modulated by copper and zinc

Molecular Pharmacology

Volumn 66, Issue 3, 2004, Pages 530-537

  Gruss, Marco ^a   Mathie, Alistair ^a   Lieb, William R ^a   Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; POTASSIUM CHANNEL; ZINC;

ACID SENSITIVE POTASSIUM CHANNEL 3; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; NERVE CELL EXCITABILITY; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; WEAKLY INWARDLY RECTIFYING POTASSIUM CHANNEL RELATED POTASSIUM CHANNEL 1;

CELLS, CULTURED; COPPER; HUMANS; NEURONS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; ZINC;

EID: 4944259428     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. 2+ from brain tissue during activity. Nature (Lond) 308:734-736.
2. 2+. Mol Pharmacol 46:1156-1159.
3. Buckler KJ, Williams BA, and Honoré E (2000) An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525:135-142.
4. Chapman CG, Meadows HJ, Godden RJ, Campbell DA, Duckworth M, Kelsell RE, Murdock PR, Randall AD, Rennie GI, and Gloger IS (2000) Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. Brain Res Mol Brain Res 82:74-83.
5. Clarke CE, Green PJ, Veale EL, Meadows HJ, and Mathie A (2003) The involvement of residues H9S and E70 in the block of the human two pore domain potassium channel, TASK-3, by zinc. J Physiol 547P:C46.
6. Czirjak G and Enyedi P (2003) Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits. Mol Pharmacol 63:646-652.
7. Frederickson CJ (1989) Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol 31:145-238.
8. Glusker JP (1991) Structural aspects of metal liganding to functional groups in proteins. Adv Protein Chem 42:1-76.
9. Goldstein SA, Bockenhauer D, O'Kelly I, and Zilberberg N (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2:175-184.
10. + channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol Pharmacol 65:443-452.
11. Harris ED (2002) Cellular transporters for zinc. Nutr Rev 60:121-124.
12. Hartter DE and Barnea A (1988) Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper. Synapse 2:412-415.
13. + channel TREK-1. EMBO (Eur Mol Biol Organ) J 21:2968-2976.
14. Horning MS, Blakemore LJ, and Trombley PQ (2000) Endogenous mechanisms of neuroprotection: role of zinc, copper and carnosine. Brain Res 852:56-61.
15. Horning MS and Trombley PQ (2001) Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms. J Neurophysiol 86:1652-1660.
16. A receptors: discrete binding sites underlie subtype specificity. Nat Neurosci 6:362-369.
17. Howell GA, Welch MG, and Frederickson CJ (1984) Stimulation-induced uptake and release of zinc in hippocampal slices. Nature (Lond) 308:736-738.
18. Kardos J, Kovacs I, Hajos F, Kalman M, and Simonyi M (1989) Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability. Neurosci Lett 103:139-144.
19. Kozma M, Szerdahelyi P, and Kasa P (1981) Histochemical detection of zinc and copper in various neurons of the central nervous system. Acta Histochem 69:12-17.
20. Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, and Yost CS (1998) An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci 18:868-877.
21. Lovinger DM (1991) Inhibition of 5-HT3 receptor-mediated ion current by divalent metal cations in NCB-20 neuroblastoma cells. J Neurophysiol 66:1329-1337.
22. 2+ currents in rat palaeocortical neurons. Neuroscience 117:249-264.
23. + channel. Biochem Biophys Res Commun 292:339-346.
24. Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, and Chapman CG (2000) Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflueg Arch Eur J Physiol 439:714-722.
25. Ono S, Koropatnick DJ, and Cherian MG (1997) Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 124:1-10.
26. Paoletti P, Ascher P, and Neyton J (1997) High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 17:5711-5725.
27. + channels. Trends Neurosci 24:339-346.
28. + channel. EMBO. (Eur Mol Biol Organ) J 17:4283-4290.
29. Puig S and Thiele DJ (2002) Molecular mechanisms of copper uptake and distribution. Curr Opin Chem Biol 6:171-180.
30. + channel. An extracellular histiding as pH sensor. J Biol Chem 275:16650-7.
31. Sato M, Ohtomo K, Daimon T, Sugiyama T, and Iijima K (1994) Localization of copper to afferent terminals in rat locus ceruleus, in contrast to mitochondrial copper in cerebellum. J Histochem Cytochem 42:1585-1591.
32. A receptor-mediated currents in acutely isolated cerebellar Purkinje cells of the rat. Eur J Neurosci 10:522-528.
33. Smart TG, Xie X, and Krishek BJ (1994) Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Prog Neurobiol 42:393-341.
34. Squitti R, Lupoi D, Pasqualetti P, Dal Forno G, Vernieri F, Chiovenda P, Rossi L, Cortesi M, Cassetta E, and Rossini PM (2002) Elevation of serum copper levels in Alzheimer's disease. Neurology 59:1153-1161.
35. Strausak D, Mercer JF, Dieter HH, Stremmel W, and Multhaup G (2001) Copper in disorders with neurological symptoms: Alzheimer's, Menkes and Wilson diseases. Brain Res Bull 55:175-185.
36. Talley EM, Solorzano G, Lei Q, Kim D, and Bayliss DA (2001) Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci 21:7491-7505.
37. Vlachova V, Zemkova H, and Vyklicky L Jr (1996) Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons. Eur J Neurosci 8:2257-2264.
38. 2+ inhibition of glycine-activated currents in rat sacral dorsal commissural neurons. Neurosci Lett 328:117-120.
39. 2+: a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 21:395-401.
40. 4 receptor function. J Neurophysiol 81:2088-2094.