Effects of VEGF on the blood-brain barrier disruption caused by hyperosmolarity

Pharmacology

Volumn 82, Issue 3, 2008, Pages 187-192

  Chi, Oak Z ^a   Hunter, Christine ^a   Liu, Xia ^a   Tan, Tao ^a   Weiss, Harvey R ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Blood brain barrier disruption; Ciclopirox olamine; Hyperosmolar solution; Vascular endothelial growth factor

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; CICLOPIROXOLAMINE; DEXTRAN; MANNITOL; SODIUM CHLORIDE; TRITIUM; VASCULOTROPIN; VASCULOTROPIN 165; VASCULOTROPIN ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTROLLED STUDY; DRUG MECHANISM; HYPEROSMOLALITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; UPREGULATION;

AMINOISOBUTYRIC ACIDS; ANIMALS; ANTIBODIES; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CRANIOTOMY; DEXTRANS; DIURETICS, OSMOTIC; MALE; MANNITOL; OSMOLAR CONCENTRATION; PARIETAL LOBE; PYRIDONES; RATS; RATS, WISTAR; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 49349096792     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151433     Document Type: Article

References (38)

1. Kroll RA, Neuwelt EA: Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 1998;42:1083-1099.
2. Rapoport SI: Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell Mol Neurobiol 2000;20:217-230.
3. Albayrak S, Zhao Q, Siesjo BK, Smith ML: Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury. Acta Neuropathol (Berl) 1997;94:158-163.
4. 2 supply/consumption heterogeneity. J Cereb Blood Flow Metab 1996;16:327-333.
5. Murakami K, Kondo T, Chan PH: Blood-brain barrier disruption, edema formation and apoptotic neuronal death following cold injury. Acta Neurochir Suppl 1997;70:234-236.
6. Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 2003;9:669-676.
7. van Bruggen N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, Tumas D, Gerlai R, Williams SP, van Lookeren Campagne M, Ferrara N: VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest 1999;104:1613-1620.
8. Schoch HJ, Fischer S, Marti HH: Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain 2002;125:2549-2557.
9. Nag S: The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model. Trends Mol Med 2002;8:38-44.
10. Heiss JD, Papavassiliou E, Merrill MJ, Nieman L, Knightly JJ, Walbridge S, Edwards NA, Oldfield EH: Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats: involvement of the glucocorticoid receptor and vascular permeability factor. J Clin Invest 1996;98:1400-1408.
11. Chi OZ, Hunter C, Liu X, Weiss HR: Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia. Exp Neurol 2007;204:283-287.
12. Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1α stability, VEGF expression, and angiogenesis. FASEB J 2003;17:761-763.
13. Baby SM, Roy A, Mokashi AM, Lahiri S: Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and -1β in the rat carotid body and glomus cells. Histochem Cell Biol 2003;120:343-352.
14. Roy A, Volgin DV, Baby SM, Mokashi A, Kubin L, Lahiri S: Activation of HIF-1α mRNA by hypoxia and iron chelator in isolated rat carotid body. Neurosci Lett 2004;363:229-232.
15. Cosolo WC, Martinello P, Louis WJ, Christophidis N: Blood-brain barrier disruption using mannitol: time course and electron microscopy studies. Am J Physiol 1989;256:R443-R447.
16. Gross PM, Blasberg RG, Fenstermacher JD, Patlak CS: The microcirculation of rat circumventricular organs and pituitary gland. Brain Res Bull 1987;18:73-85.
17. Chi OZ, Anwar M, Sinha AK, Weiss HR: Effects of isoflurane on transport across the blood-brain barrier. Anesthesiology 1992;76:426-431.
18. Smith QR: Quantitation of blood-brain barrier permeability; in Neuwelt EA (ed): Implications of the Blood-Brain Barrier and Its Manipulation: Basic Science Aspects. New York, Plenum Press, 1989, vol 1, pp 85-118.
19. Ravussin P, Archer DP, Tyler JL, Meyer E, Abou-Madi M, Diksic M, Yamamoto L, Trop D: Effects of rapid mannitol infusion on cerebral blood volume: a positron emission tomographic study in dogs and man. J Neurosurg 1986;64:104-113.
20. Lin W, Paczynski RP, Kuppusamy K, Hsu CY, Haacke EM: Quantitative measurements of regional cerebral blood volume using MRI in rats: effects of arterial carbon dioxide tension and mannitol. Magn Reson Med 1997;38:420-428.
21. Gumbiner BM: Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996;84:345-357.
22. Staddon JM, Rubin LL: Cell adhesion, cell junctions and the blood-brain barrier. Curr Opin Neurobiol 1996;6:622-627.
23. Nagashima T, Shijing W, Mizoguchi A, Tamaki N: A possible role of calcium ion in osmotic opening of blood-brain barrier. J Auton Nerv Syst 1994;49:S145-S149.
24. Abbott NJ, Revest PA: Control of brain endothelial permeability. Cerebrovasc Brain Metab Rev 1991;3:39-72.
25. Olesen SP: Regulation of ion permeability in frog brain venules: significance of calcium, cyclic nucleotides and protein kinase C. J Physiol 1987;387:59-69.
26. Rapoport SI: Modulation of blood-brain barrier permeability. J Drug Target 1996;3:417-425.
27. Sanovich E, Bartus RT, Friden PM, Dean RL, Le HQ, Brightman MW: Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res 1995;705:125-135.
28. Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, Isner JM: Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 1998;97:99-107.
29. Chi OZ, Hunter C, Liu X, Weiss HR: Effects of VEGF and nitric oxide synthase inhibition on blood-brain barrier disruption in the ischemic and non-ischemic cerebral cortex. Neurol Res 2005;27:864-868.
30. Mayhan WG: VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. Am J Physiol 1999;276:C1148-C1153.
31. Sirois MD, Edelman ER: VEGF effect on vascular permeability is mediated by synthesis of platelet activating factor. Am J Physiol 1997;272:H2746-H2756.
32. 2+-dependent pathway. Am J Physiol 1997;273:H687-H694.
33. Hippenstiel S, Krüll M, Ikemann A, Risau W, Clauss M, Suttorp N: VEGF induces hyperpermeability by a direct action on endothelial cells. Am J Physiol 1998;274:L678-L684.
34. Fischer S, Wobben M, Marti HH, Renz D, Schaper W: Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1. Microvasc Res 2002;63:70-80.
35. Wang W, Dentler WL, Borchardt RT: VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly. Am J Physiol 2001;280:H434-H440.
36. Breslin JW, Pappas PJ, Cerveira JJ, Hobson RW 2nd, Durán WN: VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol 2003;284:H92-H100.
37. Martínez-Estrada OM, Rodríguez-Millán E, González-De Vicente E, Reina M, Vilaró S, Fabre M: Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability. Eur J Neurosci 2003;18:2538-2544.
38. Chi OZ, Chang Q, Wang G, Weiss HR: Effects of nitric oxide on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth Analg 1997;84:370-375.