Activation of HIF-1α mRNA by hypoxia and iron chelator in isolated rat carotid body

Neuroscience Letters

Volumn 363, Issue 3, 2004, Pages 229-232

  Roy, Arijit ^a   Volgin, Denys V ^a   Baby, Santhosh M ^a   Mokashi, Anil ^a   Kubin, Leszek ^a   Lahiri, Sukhamay ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Carotid body; Ciclopirox olamine; Hypoxia inducible factor 1 mRNA; Iron chelator; Reverse transcription and polymerase chain reaction (RT PCR)

Indexed keywords

CICLOPIROXOLAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; CICLOPIROX; IRON CHELATING AGENT; PYRIDONE DERIVATIVE; TRANSCRIPTION FACTOR;

ARTICLE; CAROTID BODY; CONTROLLED STUDY; CULTURE MEDIUM; GENETIC TRANSCRIPTION; MALE; NONHUMAN; OXYGEN SATURATION; OXYGEN SUPPLY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; ANOXIA; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; METABOLISM; METHODOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; CAROTID BODY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON CHELATING AGENTS; MALE; OXYGEN; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 2942555355     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.03.073     Document Type: Article

References (26)

1. Baby S.M., Roy A., Mokashi A.M., Lahiri S. Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and -1β in the rat carotid body and glomus cells. Histochem. Cell Biol. 120:2003;343-352
2. Bee D., Pallott D.J., Barer G.R. Division of type I and endothelial cells in the hypoxic rat carotid body. Acta Anat. 126:1986;226-229
3. Bergeron M., Aimee Y.Y., Karen E.S., Semenza G.L., Sharp F.R. Induction of hypoxia-inducible factor (HIF-1) and its target genes following focal ischaemia in rat brain. Eur. J. Neurosci. 11:1999;4159-4170
4. Dhillon D.P., Barer G.R., Walsh M. The enlarged carotid body of the chronically hypoxic and hypercapnic rat: a morphometric analysis. J. Exp. Physiol. 69:1984;301-317
5. Ehleben W., Porwol T., Fandrey J., Kummer W., Acker H. Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in Hep G2 cells. Kidney Int. 51:1997;483-491
6. Fandrey J., Bunn F. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood. 81:1993;617-623
7. Goldberg M.A., Dunning S.P., Bunn H.F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science. 242:1988;1412-1415
8. Huang L.E., Arany Z., Livingston D.M., Bunn H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox sensitive stabilization of its α?subunit. J. Biol. Chem. 271:1996;32253-32259
9. 2 tension. Am. J. Physiol. 271:1996;C1172-C1180
10. Kallio P.J., Pongratz I., Gradin K., McGuire J., Poellinger L. Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc. Natl. Acad. Sci. USA. 94:1997;5667-5672
11. Kline D.D., Peng Y.-J., Manalo D.J., Semenza G.L., Prabhakar N.R. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α Proc. Natl. Acad. Sci. USA. 99:2002;821-826
12. Kubin L., Czyżyk-Krzeska M.F., Gozal D. Gene and protein expression and regulation in the central nervous system. Carley D.W., Radulovacki M. Sleep-Related Breathing Disorders: Experimental Models and Therapeutic Potential. 2002;109-179 Marcel Dekker, New York
13. Lahiri S., Rozanov C., Roy A., Storey B., Buerk D.G. Regulation of oxygen sensing in peripheral arterial chemoreceptors. Int. J. Biochem. Cell Biol. 33:2001;755-774
14. Linden T., Katschinski D.M., Eckhardt K., Scheid A., Pagel H., Wenger R.H. The antimycotic ciclopirox olamine induces HIF-1α stability, VEGF expression, and angiogenesis, FASEB J. 17:2003;761-763
15. McGregor K.H., Gill J., Lahiri S. A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. 57:1984;1430-1438
16. Ohh M., Park C.W., Ivan M., Hoffman M.A., Kim T.Y., Huang L.E., Pavletich N., Chau V., Kaelin W.G. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2:2000;423-427
17. 2 interaction in the rat carotid body in vitro. J. Physiol. (Lond. 485:1995;531-541
18. I and CSN activity in the adult rat carotid body. Respir. Physiol. 122:2000;15-26
19. Semenza G.L. HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13:2001;167-171
20. Tipoe G.L., Fung M.-L. Expression of HIF-1α, VEGF and VEGF receptors in the carotid body of chronically hypoxic rat, Respir. Physiol. Neurobiol. 138:2003;143-154
21. 1B receptors are the main postsynaptic mediators of adrenergic excitation in brainstem motoneurons, a single-cell RT-PCR study. J. Chem. Neuroanat. 22:2001;157-166
22. Volgin D., Saghir M., Kubin L. Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons. NeuroReport. 13:2002;433-436
23. Wang G.L., Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 82:1993;3610-3615
24. 2 tension. Proc. Natl. Acad. Sci. USA. 92:1995;5510-5514
25. Wanner R.M., Spielmann P., Stroka D.M., Camenisch G., Camenisch I., Scheid A., Houck D.R., Bauer C., Gassmann M., Wenger R.H. Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation. Blood. 96:2000;1558-1565
26. 2 of the carotid body. Lahiri S., Prabhakar N.R., Foster R.E. Oxygen Sensing: from Molecule to Man. Oxygen Sensing: from Molecule to Man. 475:2000;637-644 Kluwer Academic/Plenum, New York