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Volumn 14, Issue 1, 2008, Pages 51-56

Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary

Author keywords

Allelic imbalance; APC; Mutation; Promoter hypermethylation; Sporadic colorectal cancer

Indexed keywords

ADENOMATOSIS; ADULT; AGED; ALLELIC IMBALANCE; ARTICLE; CANCER SCREENING; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; FRAMESHIFT MUTATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; MISSENSE MUTATION; PROMOTER REGION;

EID: 49349088305     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9019-y     Document Type: Article
Times cited : (11)

References (39)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • 5
    • ER Fearon B Vogelstein 1990 A genetic model for colorectal tumorigenesis Cell 61 5 759 767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 33745809820 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC) differently regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    • 26
    • J Yang W Zhang PM Evans 2006 Adenomatous polyposis coli (APC) differently regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells J Biol Chem 281 26 17751 17757
    • (2006) J Biol Chem , vol.281 , pp. 17751-17757
    • Yang, J.1    Zhang, W.2    Evans, P.M.3
  • 3
    • 34548174902 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia
    • 2
    • T Senda A Iizuka-Kogo T Onouchi 2007 Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia Med Mol Morphol 40 2 68 81
    • (2007) Med Mol Morphol , vol.40 , pp. 68-81
    • Senda, T.1    Iizuka-Kogo, A.2    Onouchi, T.3
  • 5
    • 0027535028 scopus 로고
    • Identification of an alternative 5′ untranslated region of the adenomatous polyposis coli gene
    • 6
    • S Lambertz WG Ballhausen 1993 Identification of an alternative 5′ untranslated region of the adenomatous polyposis coli gene Hum Genet 90 6 650 652
    • (1993) Hum Genet , vol.90 , pp. 650-652
    • Lambertz, S.1    Ballhausen, W.G.2
  • 6
    • 0028229809 scopus 로고
    • Demonstration of promoter activity and alternative splicing in the region 5′ to exon 1 of the APC gene
    • 11
    • A Thliveris W Samowitz N Matsunami 1994 Demonstration of promoter activity and alternative splicing in the region 5′ to exon 1 of the APC gene Cancer Res 54 11 2991 2995
    • (1994) Cancer Res , vol.54 , pp. 2991-2995
    • Thliveris, A.1    Samowitz, W.2    Matsunami, N.3
  • 7
    • 0034662626 scopus 로고    scopus 로고
    • Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
    • 16
    • M Esteller A Sparks M Toyota 2000 Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer Cancer Res 60 16 4366 4371
    • (2000) Cancer Res , vol.60 , pp. 4366-4371
    • Esteller, M.1    Sparks, A.2    Toyota, M.3
  • 8
    • 0034927849 scopus 로고    scopus 로고
    • Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas
    • 7
    • Z Xiong AH Wu CM Bender 2001 Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas Cancer Epidemiol Biomarkers Prev 10 7 799 803
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 799-803
    • Xiong, Z.1    Wu, A.H.2    Bender, C.M.3
  • 9
    • 0034807280 scopus 로고    scopus 로고
    • Methylation and colorectal cancer
    • 1
    • AM Jubb SM Bell P Quirke 2001 Methylation and colorectal cancer J Pathol 195 1 111 134
    • (2001) J Pathol , vol.195 , pp. 111-134
    • Jubb, A.M.1    Bell, S.M.2    Quirke, P.3
  • 10
    • 0027146559 scopus 로고
    • Mutations of the APC (adenomatous polyposis coli) gene
    • 6
    • H Nagase Y Nakamura 1993 Mutations of the APC (adenomatous polyposis coli) gene Hum Mutat 2 6 425 434
    • (1993) Hum Mutat , vol.2 , pp. 425-434
    • Nagase, H.1    Nakamura, Y.2
  • 11
    • 0027535407 scopus 로고
    • Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis
    • 2
    • L Varesco V Gismondi R James 1993 Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis Am J Hum Genet 52 2 280 285
    • (1993) Am J Hum Genet , vol.52 , pp. 280-285
    • Varesco, L.1    Gismondi, V.2    James, R.3
  • 12
    • 0032947835 scopus 로고    scopus 로고
    • Molecular analysis of the APC gene in 205 families: Extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition
    • 1
    • YL Wallis DG Morton CM McKeown 1999 Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition J Med Genet 36 1 14 20
    • (1999) J Med Genet , vol.36 , pp. 14-20
    • Wallis, Y.L.1    Morton, D.G.2    McKeown, C.M.3
  • 13
    • 33845373278 scopus 로고    scopus 로고
    • Colorectal cancer and genetic alterations in the Wnt pathway
    • 57
    • S Segditsas I Tomlinson 2006 Colorectal cancer and genetic alterations in the Wnt pathway Oncogene 25 57 7531 7537
    • (2006) Oncogene , vol.25 , pp. 7531-7537
    • Segditsas, S.1    Tomlinson, I.2
  • 15
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • 5
    • M Frommer LE McDonald DS Millar 1992 A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands Proc Natl Acad Sci USA 89 5 1827 1831
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 16
    • 0035870280 scopus 로고    scopus 로고
    • Epigenetic patterns in the progression of esophageal adenocarcinoma
    • 8
    • CA Eads RV Lord K Wickramasinghe 2001 Epigenetic patterns in the progression of esophageal adenocarcinoma Cancer Res 61 8 3410 3418
    • (2001) Cancer Res , vol.61 , pp. 3410-3418
    • Eads, C.A.1    Lord, R.V.2    Wickramasinghe, K.3
  • 17
  • 18
    • 0028231090 scopus 로고
    • The 1993-94 Genethon human genetic linkage map
    • 2 Spec No
    • G Gyapay J Morissette A Vignal 1994 The 1993-94 Genethon human genetic linkage map Nat Genet 7 2 Spec No 246 339
    • (1994) Nat Genet , vol.7 , pp. 246-339
    • Gyapay, G.1    Morissette, J.2    Vignal, A.3
  • 19
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • 3
    • J Groden A Thliveris W Samowitz 1991 Identification and characterization of the familial adenomatous polyposis coli gene Cell 66 3 589 600
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 20
    • 11944252481 scopus 로고
    • Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients
    • 10
    • Y Miyoshi H Ando H Nagase 1992 Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients Proc Natl Acad Sci USA 89 10 4452 4456
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4452-4456
    • Miyoshi, Y.1    Ando, H.2    Nagase, H.3
  • 21
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • 13
    • PC Ng S Henikoff 2003 SIFT: predicting amino acid changes that affect protein function Nucleic Acids Res 31 13 3812 3814
    • (2003) Nucleic Acids Res , vol.31 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 22
    • 0035869223 scopus 로고    scopus 로고
    • Prediction of deleterious human alleles
    • 6
    • S Sunyaev V Ramensky I Koch 2001 Prediction of deleterious human alleles Hum Mol Genet 10 6 591 597
    • (2001) Hum Mol Genet , vol.10 , pp. 591-597
    • Sunyaev, S.1    Ramensky, V.2    Koch, I.3
  • 23
    • 10344242920 scopus 로고    scopus 로고
    • Sequence-based prediction of pathological mutations
    • 4
    • C Ferrer-Costa M Orozco X de la Cruz 2004 Sequence-based prediction of pathological mutations Proteins 57 4 811 819
    • (2004) Proteins , vol.57 , pp. 811-819
    • Ferrer-Costa, C.1    Orozco, M.2    De La Cruz, X.3
  • 24
    • 21244500864 scopus 로고    scopus 로고
    • APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q
    • 10
    • CN Arnold A Goel D Niedzwiecki 2004 APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q Cancer Biol Ther 3 10 960 964
    • (2004) Cancer Biol Ther , vol.3 , pp. 960-964
    • Arnold, C.N.1    Goel, A.2    Niedzwiecki, D.3
  • 25
    • 14644442314 scopus 로고    scopus 로고
    • Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability
    • 2
    • L Thorstensen GE Lind T Løvig 2005 Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability Neoplasia 7 2 99 108
    • (2005) Neoplasia , vol.7 , pp. 99-108
    • Thorstensen, L.1    Lind, G.E.2    Løvig, T.3
  • 26
    • 0036022107 scopus 로고    scopus 로고
    • Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers
    • 1
    • T Furukawa F Konishi S Masubuchi 2002 Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers Genes Chromosomes Cancer 35 1 1 10
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 1-10
    • Furukawa, T.1    Konishi, F.2    Masubuchi, S.3
  • 27
    • 33846525014 scopus 로고    scopus 로고
    • Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC) gene
    • 3
    • F Prall V Weirich C Ostwald 2007 Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC) gene Histopathology 50 3 318 330
    • (2007) Histopathology , vol.50 , pp. 318-330
    • Prall, F.1    Weirich, V.2    Ostwald, C.3
  • 28
    • 0032823133 scopus 로고    scopus 로고
    • The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: A new facet to Knudson's 'two-hit' hypothesis
    • 9
    • H Lamlum M Ilyas A Rowan 1999 The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis Nat Med 5 9 1071 1075
    • (1999) Nat Med , vol.5 , pp. 1071-1075
    • Lamlum, H.1    Ilyas, M.2    Rowan, A.3
  • 29
    • 16944365288 scopus 로고    scopus 로고
    • Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
    • 1
    • SJ Laken GM Petersen SB Gruber 1997 Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC Nat Genet 17 1 79 83
    • (1997) Nat Genet , vol.17 , pp. 79-83
    • Laken, S.J.1    Petersen, G.M.2    Gruber, S.B.3
  • 30
    • 26844479501 scopus 로고    scopus 로고
    • Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients
    • 1
    • M Mihalatos A Apessos H Dauwerse 2005 Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients BMC Cancer 5 1 40 47
    • (2005) BMC Cancer , vol.5 , pp. 40-47
    • Mihalatos, M.1    Apessos, A.2    Dauwerse, H.3
  • 31
    • 0037389343 scopus 로고    scopus 로고
    • Genetic analysis of familial colorectal cancer in Israeli Arabs
    • 4
    • R Chen-Shtoyerman L Theodor E Harmati 2003 Genetic analysis of familial colorectal cancer in Israeli Arabs Hum Mutat 21 4 446 447
    • (2003) Hum Mutat , vol.21 , pp. 446-447
    • Chen-Shtoyerman, R.1    Theodor, L.2    Harmati, E.3
  • 32
    • 19044395448 scopus 로고    scopus 로고
    • Molecular analysis of the APC gene in 71 Israeli families: 17 novel mutations
    • 6
    • N Gavert Y Yaron T Naiman 2002 Molecular analysis of the APC gene in 71 Israeli families: 17 novel mutations Hum Mutat 19 6 664
    • (2002) Hum Mutat , vol.19 , pp. 664
    • Gavert, N.1    Yaron, Y.2    Naiman, T.3
  • 33
    • 0027320554 scopus 로고
    • Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis
    • 7
    • P Paul T Letteboer L Gelbert 1993 Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis Hum Mol Genet 2 7 925 931
    • (1993) Hum Mol Genet , vol.2 , pp. 925-931
    • Paul, P.1    Letteboer, T.2    Gelbert, L.3
  • 34
    • 33646147162 scopus 로고    scopus 로고
    • Novel germline mutations in the APC gene of Cypriot patients with familial and sporadic adenomatous polyposis
    • 5
    • A Hadjisavvas T Papasavva M Loizidou 2006 Novel germline mutations in the APC gene of Cypriot patients with familial and sporadic adenomatous polyposis Clin Genet 69 5 404 409
    • (2006) Clin Genet , vol.69 , pp. 404-409
    • Hadjisavvas, A.1    Papasavva, T.2    Loizidou, M.3
  • 35
    • 34548472447 scopus 로고    scopus 로고
    • How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population
    • 2
    • M Dundar AO Caglayan C Saatci 2007 How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population Cancer Genet Cytogenet 177 2 95 97
    • (2007) Cancer Genet Cytogenet , vol.177 , pp. 95-97
    • Dundar, M.1    Caglayan, A.O.2    Saatci, C.3
  • 36
    • 33845607724 scopus 로고    scopus 로고
    • Promoter methylation precedes chromosomal alterations in colorectal cancer development
    • 5-6
    • S Derks C Postma PT Moerkerk 2006 Promoter methylation precedes chromosomal alterations in colorectal cancer development Cell Oncol 28 5-6 247 527
    • (2006) Cell Oncol , vol.28 , pp. 247-527
    • Derks, S.1    Postma, C.2    Moerkerk, P.T.3
  • 37
    • 33846192840 scopus 로고    scopus 로고
    • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    • 1
    • A Goel T Nagasaka CN Arnold 2007 The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer Gastroenterology 132 1 127 138
    • (2007) Gastroenterology , vol.132 , pp. 127-138
    • Goel, A.1    Nagasaka, T.2    Arnold, C.N.3
  • 38
    • 33947259556 scopus 로고    scopus 로고
    • APC mutations and other genetic and epigenetic changes in colon cancer
    • 2
    • WS Samowitz ML Slattery C Sweeney 2007 APC mutations and other genetic and epigenetic changes in colon cancer Mol Cancer Res 5 2 165 170
    • (2007) Mol Cancer Res , vol.5 , pp. 165-170
    • Samowitz, W.S.1    Slattery, M.L.2    Sweeney, C.3
  • 39
    • 18644370130 scopus 로고    scopus 로고
    • Mutations of the APC gene in human sporadic colorectal cancers
    • 9
    • C De Filippo C Luceri G Caderni 2002 Mutations of the APC gene in human sporadic colorectal cancers Scand J Gastroenterol 37 9 1048 1053
    • (2002) Scand J Gastroenterol , vol.37 , pp. 1048-1053
    • De Filippo, C.1    Luceri, C.2    Caderni, G.3


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