Paracrine effects of hypoxic fibroblast-derived factors on the MPT-ROS threshold and viability of adult rat cardiac myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 6, 2008, Pages

  Shivakumar, K ^a   Sollott, S J ^b   Sangeetha, M ^a   Sapna, S ^a   Ziman, B ^b   Wang, S ^b   Lakatta, E G ^b  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Apoptosis; Cardiac fibroblasts; Cardiac myocyte viability; Fibroblast proliferation; Fibroblast conditioned medium; Hypoxia; Mitochondrial permeability transition reactive oxygen species threshold; Necrosis; Tumor necrosis factor

Indexed keywords

ANNEXIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; CARRIER PROTEIN; CYTOKINE; INTERLEUKIN 4; INTERLEUKIN 6; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL HYPOXIA; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SYNTHESIS; FIBROBLAST; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; ANIMAL; CELL CULTURE; CELL SHAPE; CELL SURVIVAL; CONFOCAL MICROSCOPY; CULTURE MEDIUM; DNA REPLICATION; HEART MITOCHONDRION; METABOLISM; PATHOLOGY; TIME; UPREGULATION; WISTAR RAT;

ANIMALS; CELL HYPOXIA; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DNA REPLICATION; FIBROBLASTS; INTERLEUKIN-4; INTERLEUKIN-6; MALE; MICROSCOPY, CONFOCAL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCYTES, CARDIAC; PARACRINE COMMUNICATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 49249137984     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.91443.2007     Document Type: Article

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