A red wine polyphenolic extract reduces the activation phenotype of cultured human liver myofibroblasts

World Journal of Gastroenterology

Volumn 14, Issue 14, 2008, Pages 2194-2199

  Neaud, Véronique ^a,b   Rosenbaum, Jean ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Hepatic stellate cells; Liver fibrosis; Myofibroblasts; Phosphorylation; Proliferation; Wine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GELATINASE A; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR BB; POLYPHENOL DERIVATIVE; PROTEIN KINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ACTIN; DNA; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPLANT; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; MITOSIS INHIBITION; MYOFIBROBLAST; PHENOTYPE; RED WINE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZYMOGRAPHY; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; FIBROBLAST; FIBROSIS; LIVER; METABOLISM; MUSCLE FIBRIL; PATHOLOGY; PHOSPHORYLATION; WINE;

ACTINS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DNA; FIBROBLASTS; FIBROSIS; FLAVONOIDS; HUMANS; LIVER; MYOFIBRILS; PHENOLS; PHENOTYPE; PHOSPHORYLATION; TETRAZOLIUM SALTS; THIAZOLES; WINE;

EID: 49249136540     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.2194     Document Type: Article

References (30)

1. Lotersztajn S, Julien B, Teixeira-Clerc F, Grenard P, Mallat A. Hepatic fibrosis: molecular mechanisms and drug targets. Annu Rev Pharmacol Toxicol 2005; 45: 605-628
2. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-218
3. Tuchweber B, Desmouliere A, Bochaton-Piallat ML, Rubbia-Brandt L, Gabbiani G. Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest 1996; 74: 265-278
4. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 2001; 12: 2730-2741
5. Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 2002; 68: 289-296
6. Stickel F, Brinkhaus B, Krahmer N, Seitz HK, Hahn EG, Schuppan D. Antifibrotic properties of botanicals in chronic liver disease. Hepatogastroenterology 2002; 49: 1102-1108
7. Kawada N, Seki S, Inoue M, Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 1998; 27: 1265-1274
8. Godichaud S, Krisa S, Couronne B, Dubuisson L, Merillon JM, Desmouliere A, Rosenbaum J. Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol. Hepatology 2000; 31: 922-931
9. Waddington E, Puddey IB, Croft KD. Red wine polyphenolic compounds inhibit atherosclerosis in apolipoprotein E-deficient mice independently of effects on lipid peroxidation. Am J Clin Nutr 2004; 79: 54-61
10. Iijima K, Yoshizumi M, Ouchi Y. Effect of red wine polyphenols on vascular smooth muscle cell function-molecular mechanism of the 'French paradox'. Mech Ageing Dev 2002; 123: 1033-1039
11. Auger C, Caporiccio B, Landrault N, Teissedre PL, Laurent C, Cros G, Besancon P, Rouanet JM. Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). J Nutr 2002; 132: 1207-1213
12. Carando S, Teissedre PL. Catechin and procyanidin levels in French wines: contribution to dietary intake. Basic Life Sci 1999; 66: 725-737
13. Win KM, Charlotte F, Mallat A, Cherqui D, Martin N, Mavier P, Preaux AM, Dhumeaux D, Rosenbaum J. Mitogenic effect of transforming growth factor-beta 1 on human Ito cells in culture: evidence for mediation by endogenous platelet-derived growth factor. Hepatology 1993; 18: 137-145
14. Blazejewski S, Preaux AM, Mallat A, Brocheriou I, Mavier P, Dhumeaux D, Hartmann D, Schuppan D, Rosenbaum J. Human myofibroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liver. Hepatology 1995; 22: 788-797
15. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-277
16. Labarca C, Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 1980; 102: 344-352
17. Neaud V, Duplantier JG, Mazzocco C, Kisiel W, Rosenbaum J. Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism. J Biol Chem 2004; 279: 5200-5206
18. Neaud V, Faouzi S, Guirouilh J, Le Bail B, Balabaud C, Bioulac-Sage P, Rosenbaum J. Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor. Hepatology 1997; 26: 1458-1466
19. Herron GS, Banda MJ, Clark EJ, Gavrilovic J, Werb Z. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem 1986; 261: 2814-2818
20. Taras D, Blanc JF, Rullier A, Dugot-Senant N, Laurendeau I, Bieche I, Pines M, Rosenbaum J. Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 2006; 8: 312-318
21. Pinzani M, Gesualdo L, Sabbah GM, Abboud HE. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989; 84: 1786-1793
22. Marra F, Gentilini A, Pinzani M, Choudhury GG, Parola M, Herbst H, Dianzani MU, Laffi G, Abboud HE, Gentilini P. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology 1997; 112: 1297-1306
23. Tangkijvanich P, Santiskulvong C, Melton AC, Rozengurt E, Yee HY Jr. p38 MAP kinase mediates platelet-derived growth factor-stimulated migration of hepatic myofibroblasts. J Cell Physiol 2002; 191: 351-361
24. Arthur MJ, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72 kDa type IV coIlagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992; 287 (Pt 3): 701-707
25. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJ. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. J Clin Invest 1992; 90: 282-287
26. Iijima K, Yoshizumi M, Hashimoto M, Akishita M, Kozaki K, Ako J, Watanabe T, Ohike Y, Son B, Yu J, Nakabara K, Ouchi Y. Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation 2002; 105: 2404-2410
27. Fremont L. Biological effects of resveratrol. Life Sci 2000; 66: 663-673
28. Godichaud S, Si-Tayeb K, Auge N, Desmouliere A, Balabaud C, Payrastre B, Negre-Salvayre A, Rosenbaum J. The grape-derived polyphenol resveratrol differentially affects epidermal and platelet-derived growth factor signaling in human liver myofibroblasts. Int J Biochem Cell Biol 2006; 38: 629-637
29. Roderfeld M, Weiskirchen R, Wagner S, Berres ML, Henkel C, Gretzinger J, Gressner AM, Matern S, Roeb E. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J 2006; 20: 444-454
30. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 2004; 40: 1106-1115